Active Recombinant Human NTN1, Fc-tagged

• Cat.No.: NTN1-428H
• Product Overview: Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.
• Source: HEK293 Cells
• Species: Human
• Tag: Fc
• Form: Lyophilized. Contains PBS with Trehalose and Brij35.
• Bio-activity: Induces axon outgrowth.
• Molecular Mass: ~90kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 0.1mg/ml after reconstitution.
• Protein length: 25-604

Gene Information

• Gene Name: NTN1 netrin 1 [ Homo sapiens ]
• Official Symbol: NTN1
• Synonyms: NTN1; netrin 1; netrin-1; Netrin 1; NTN1L; netrin 1, mouse, homolog of
• Gene ID: 9423
• mRNA Refseq: NM_004822
• Protein Refseq: NP_004813
• MIM: 601614
• UniProt ID: O95631
• Chromosome Location: 17p13-p12
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; DCC mediated attractive signaling, organism-specific biosystem; DSCAM interactions, organism-specific biosystem
• Function: protein binding

Reviews

04/26/2022

It has high biological activity, high clearance rate and high safety.

02/03/2021

The storage conditions are broad and do not affect the activity of the protein,

01/27/2019

This protein is very reproducible.

Q&As

Are there have any use of NTN1 protein in cancer immunotherapy?

The targeted effect of NTN1 protein can be used to develop tumor immunotherapy drugs for the immune recognition and killing mechanism of tumors.

What are the applications of NTN1 protein in restorative and regenerative medicine?

NTN1 protein can help with cell migration, proliferation, and directed growth, so it may be a potential therapeutic target for cell therapy and restorative medicine.

In which diseases does NTN1 protein play an important role?

NTN1 protein not only plays an important role in the development of the nervous system, but also closely related to the occurrence and development of various diseases such as nervous system tumors, cardiovascular diseases and inflammatory diseases.

Is the NTN1 protein associated with inflammation?

Yes, NTN1 protein is involved in the regulatory process of inflammatory response and may play an important role in the occurrence and development of inflammatory diseases.

What is the role of NTN1 protein in autoimmune diseases?

This protein is closely related to the occurrence and progression of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, and may be involved in the regulation of autoimmune responses.

Why does NTN1 protein play a role in transplantation immunity?

NTN1 protein may be involved in the regulation of graft rejection, affecting immune tolerance and treatment efficacy after transplantation. It is also a potential transplant immunotherapy target.