| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
48-1607 aa |
| Description : |
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. |
| Molecular Mass : |
176 kDa |
| N-terminal Sequence
Analysis : |
Ala48 |
| Bio-activity : |
Measured by the ability of the immobilized protein to support the adhesion of SVEC4‑10 mouse vascular endothelial cells. The ED50 for this effect is 0.1-0.6 μg/mL. |
| Endotoxin : |
<0.10 EU/μg of the protein by the LAL method. |
| Purity : |
> 85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
| Storage : |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution : |
Reconstitute at 500 μg/mL in PBS. |
| Shipping : |
The product is shipped at ambient temperature. |
| Reference : |
1. Kuo, M.W. et al. (2011) PLoS One 6: e29000.
2. Tomas, N.M. et al. (2014) N. Engl. J. Med. 371:2277.
3. Wang, C.H. et al. (2010) J. Cell Physiol. 222: 685. |
