ARE Reporter Kit (Nrf2 Antioxidant Pathway )
| Cat.No. : | Kit-1680 |
| Product Overview : | The Nrf2 antioxidant response pathway plays an important role in the cellular antioxidant defense. Nrf2, a basic leucine zipper transcription factor, induces the expression of antioxidant and phase II enzymes by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress and other ARE activators, Nrf2 is released from Keap1 and translocates to nucleus, where it can bind to the ARE, leading to the expression of antioxidant and phase II enzymes that protect the cell from oxidative damage. |
- Specification
- Gene Information
- Related Products
| Size : | 500 reactions |
| Applications : | Monitor Nrf2 antioxidant response pathway activity. Screen for activators or inhibitors of the Nrf2 antioxidant response pathway. Study effects of RNAi or gene overexpression on the activity of the Nrf2 pathway. |
| Storage : | Stable at least 12 months from date of receipt, when stored as directed (-20°C) |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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