CRE/CREB Reporter Kit (cAMP/PKA Signaling Pathway)

• Cat.No.: Kit-1709
• Product Overview: The main role of the cAMP response element, or CRE, is mediating the effects of Protein Kinase A (PKA) by way of transcription. It is the main binding site of CREB and is responsible for its activation. CRE is at the focus of many extracellular and intracellular signaling pathways, including cAMP, calcium, GPCR (G-protein coupled receptors) and neurotrophins. The cAMP/PKA signaling pathway is critical to numerous life processes and living organisms. In the cAMP/PKA signaling pathway, CREB is activated via phosphorylation of PKA and binds to CRE with a general motif of 5"-TGACGTCA-3". Since CRE is a modulator of the cAMP/PKA signaling pathway, it allows the effects of various inhibitors to be studied.

Specification

• Size: 500 reactions
• Applications: Monitor the JNK signaling pathway activity and AP1-mediated activity.Screen for activators or inhibitors of the JNK signaling pathway.Study effects of RNAi or gene overexpression on the activity of the JNK pathway.
• Storage: Stable at least 12 months from date of receipt, when stored as directed (-20°C)