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| Cat. No.: | BCL2-5296H |
| Product Overview: | Recombinanthuman BCL2 with His Tag was expressed in E. coli. |
| Description: | Recombinanthuman BCL2 with His Tag, excluding the BH4 domain, which corresponds to aminoacids 10-30. This is a single, non-glycosylated polypeptide chain containing197 amino acid residues consisting of amino acids 1-9 and 31-218. |
| Source: | E. coli |
| Species: | Human |
| Form: | Lyophilized from asterile filtered solution containing 10 mM Tris-HCl, pH 8.0 + 1 mM EDTA + 250mM NaCl. |
| Purity: | > 95% asdetermined by RP-HPLC and SDS-PAGE analyses. |
| Storage: | Store lyophilizedprotein at -20°C to -80°C. Reconstituted protein is stable for 1 week at2-4°C. For long term storage, aliquot and store at -20°C to -80°C with acarrier protein (0.1% HSA or BSA) as a stabilizer. Please note that theaddition of any carrier protein into this product may produce unwantedendotoxin. This depends upon the particular application employed. Avoidrepeated freeze-thaw cycles. |
| OfficialSymbol: | BCL2 |
| Gene Name: | BCL2 B-cell CLL/lymphoma 2 [ Homosapiens ] |
| Synonyms: | BCL2; B-cellCLL/lymphoma 2; Bcl-2; PPP1R50; apoptosisregulator Bcl-2; protein phosphatase 1, regulatory subunit 50 |
| Gene ID: | 596 |
| mRNA Refseq: | NM_000633 |
| Protein Refseq: | NP_000624 |
| MIM: | 151430 |
| UniProt ID: | P10415 |
| Chromosome Location: | 18q21.33; 18q21.3 |
| Pathway: | ATF-2 transcriptionfactor network; Activation of BAD and translocation to mitochondria;Activation of BH3-only proteins; Amyotrophic lateral sclerosis (ALS);Apoptosis; B Cell Receptor Signaling Pathway; BH3-only proteins associatewith and inactivate anti-apoptotic BCL-2 members; Caspase cascade inapoptosis; Cholinergic synapse; Colorectal cancer; RXR and RARheterodimerization with other nuclear receptor; Small cell lung cancer; TheNLRP1 inflammasome; Toxoplasmosis; Tuberculosis |
| Function: | BH3 domain binding;channel activity; identical protein binding; protease binding; protein binding;protein heterodimerization activity; protein homodimerization activity;protein phosphatase 2A binding; sequence-specific DNA binding; transcriptionfactor binding; ubiquitin protein ligase binding |
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