Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged
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| Cat. No. : | BCL2-5296H |
| Product Overview : | Recombinanthuman BCL2 with His Tag was expressed in E. coli. |
| Description : | Recombinanthuman BCL2 with His Tag, excluding the BH4 domain, which corresponds to aminoacids 10-30. This is a single, non-glycosylated polypeptide chain containing197 amino acid residues consisting of amino acids 1-9 and 31-218. |
| Source : | E. coli |
| Species : | Human |
| Form : | Lyophilized from asterile filtered solution containing 10 mM Tris-HCl, pH 8.0 + 1 mM EDTA + 250mM NaCl. |
| Purity : | > 95% asdetermined by RP-HPLC and SDS-PAGE analyses. |
| Storage : | Store lyophilizedprotein at -20°C to -80°C. Reconstituted protein is stable for 1 week at2-4°C. For long term storage, aliquot and store at -20°C to -80°C with acarrier protein (0.1% HSA or BSA) as a stabilizer. Please note that theaddition of any carrier protein into this product may produce unwantedendotoxin. This depends upon the particular application employed. Avoidrepeated freeze-thaw cycles. |
| OfficialSymbol : | BCL2 |
| PDB rendering basedon 1GJH, 1G5M. : |
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| Gene Name : | BCL2 B-cell CLL/lymphoma 2 [ Homosapiens ] |
| Synonyms : | BCL2; B-cellCLL/lymphoma 2; Bcl-2; PPP1R50; apoptosisregulator Bcl-2; protein phosphatase 1, regulatory subunit 50 |
| Gene ID : | 596 |
| mRNA Refseq : | NM_000633 |
| Protein Refseq : | NP_000624 |
| MIM : | 151430 |
| UniProt ID : | P10415 |
| Chromosome Location : | 18q21.33; 18q21.3 |
| Pathway : | ATF-2 transcriptionfactor network; Activation of BAD and translocation to mitochondria;Activation of BH3-only proteins; Amyotrophic lateral sclerosis (ALS);Apoptosis; B Cell Receptor Signaling Pathway; BH3-only proteins associatewith and inactivate anti-apoptotic BCL-2 members; Caspase cascade inapoptosis; Cholinergic synapse; Colorectal cancer; RXR and RARheterodimerization with other nuclear receptor; Small cell lung cancer; TheNLRP1 inflammasome; Toxoplasmosis; Tuberculosis |
| Function : | BH3 domain binding;channel activity; identical protein binding; protease binding; protein binding;protein heterodimerization activity; protein homodimerization activity;protein phosphatase 2A binding; sequence-specific DNA binding; transcriptionfactor binding; ubiquitin protein ligase binding |
◆ Recombinant Protein
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| BCL2-26734TH | Recombinant Human BCL2 protein, GST-tagged | +Inquiry |
| BCL2-4221H | Recombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged | +Inquiry |
| BCL2-143H | Recombinant Human BCL2 Protein, GST-tagged | +Inquiry |
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◆ Assay kits
| Kit-1686 | BCL-2 TR-FRET Assay Kit | +Inquiry |
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BCL10BCL2BCL2L1BCL2L11BCL2L2BCL6BCL3BCL2A1BCL2L12BCL7BBCL7CBCL9BCL11ABCL2L10BCL2L13BCL2L14BCL9LBCL11BBCL7ABCL6BBCL2L15Bcl2a1bBcl2a1dBcl2a1aBcl2a1c
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