Cat. No. :	BCL2-5296H
Product Overview :	Recombinanthuman BCL2 with His Tag was expressed in E. coli.
Description :	Recombinanthuman BCL2 with His Tag, excluding the BH4 domain, which corresponds to aminoacids 10-30. This is a single, non-glycosylated polypeptide chain containing197 amino acid residues consisting of amino acids 1-9 and 31-218.
Source :	E. coli
Species :	Human
Form :	Lyophilized from asterile filtered solution containing 10 mM Tris-HCl, pH 8.0 + 1 mM EDTA + 250mM NaCl.
Purity :	> 95% asdetermined by RP-HPLC and SDS-PAGE analyses.
Storage :	Store lyophilizedprotein at -20°C to -80°C. Reconstituted protein is stable for 1 week at2-4°C. For long term storage, aliquot and store at -20°C to -80°C with acarrier protein (0.1% HSA or BSA) as a stabilizer. Please note that theaddition of any carrier protein into this product may produce unwantedendotoxin. This depends upon the particular application employed. Avoidrepeated freeze-thaw cycles.
OfficialSymbol :	BCL2

Gene Name :	BCL2 B-cell CLL/lymphoma 2 [ Homosapiens ]
Synonyms :	BCL2; B-cellCLL/lymphoma 2; Bcl-2; PPP1R50; apoptosisregulator Bcl-2; protein phosphatase 1, regulatory subunit 50
Gene ID :	596
mRNA Refseq :	NM_000633
Protein Refseq :	NP_000624
MIM :	151430
UniProt ID :	P10415
Chromosome Location :	18q21.33; 18q21.3
Pathway :	ATF-2 transcriptionfactor network; Activation of BAD and translocation to mitochondria;Activation of BH3-only proteins; Amyotrophic lateral sclerosis (ALS);Apoptosis; B Cell Receptor Signaling Pathway; BH3-only proteins associatewith and inactivate anti-apoptotic BCL-2 members; Caspase cascade inapoptosis; Cholinergic synapse; Colorectal cancer; RXR and RARheterodimerization with other nuclear receptor; Small cell lung cancer; TheNLRP1 inflammasome; Toxoplasmosis; Tuberculosis
Function :	BH3 domain binding;channel activity; identical protein binding; protease binding; protein binding;protein heterodimerization activity; protein homodimerization activity;protein phosphatase 2A binding; sequence-specific DNA binding; transcriptionfactor binding; ubiquitin protein ligase binding

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