Recombinant Human Nerve Growth Factor (beta polypeptide)

• Cat.No.: NGF-1178H
• Product Overview: Recombinant human NGFexpressed from human 293 cells as a non-disulfide bonded homodimeric proteinwith an apparent molecular mass of 13 kDa.

Specification

• Cat. No.: NGF-1178H
• Description: NGF is critical forthe survival and maintenance of sympathetic and sensory nuerons and may playan important role in the regulation of the immune system . Nerve growthfactor (NGF) is a small secreted protein that is important for the growth,maintenance, and survival of certain target neurons (nerve cells). It alsofunctions as a signaling molecule.
• Source: HEK 293 cells
• Species: Human
• MolecularWeight: 13 kDa,non-disulfide bonded homodimer, non-glycosylated.
• Purity: >95%. The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Endotoxin Level: Endotoxin Free
• Biological Activity: 1 to 8 ng/mL ED50
• OfficialSymbol: NGF

Gene Information

• Gene Name: NGF nerve growth factor (betapolypeptide) [ Homo sapiens ]
• Synonyms: NGF; nerve growthfactor (beta polypeptide); NGFB; HSAN5; Beta-NGF; MGC161426; MGC161428;beta-nerve growth factor; OTTHUMP00000013653; nerve growth factor, betasubunit
• Gene ID: 4803
• mRNA Refseq: NM_002506
• Protein Refseq: NP_002497
• MIM: 162030
• UniProt ID: P01138
• Chromosome Location: 1p13.1
• Pathway: ARMS-mediatedactivation; Cell death signalling via NRAGE; Frs2-mediated activation; MAPKsignaling pathway; NADE modulates death signalling; NRAGE signals deaththrough JNK; PLC-gamma1 signalling; Retrograde neurotrophin signalling;Retrograde neurotrophin signalling; Signalling to p38 via RIT and RIN; TRKAactivation by NGF; p75NTR negatively regulates cell cycle via SC1; p75NTRregulates axonogenesis; p75NTR signals via NF-kB
• Function: growth factoractivity; nerve growth factor receptor binding; receptor signaling proteinactivity; signal transducer activity