Active Recombinant Human DEFB4A protein
Cat.No. : | DEFB4A-5192H |
Product Overview : | Recombinant Human DEFB4A, a single, non-glycosylated polypeptide chain containing 50 amino acids was expressed in E. coli. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB, pH 7.4 + 130 mM NaCl. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 100 ng/ml.Specific Activity: >1.0 × 10^4 IU/mg. |
Molecular Mass : | 6.0 kDa |
Protein length : | 50 amino acids |
Endotoxin : | Less than 1EU/μg as determined by LAL method. |
Purity : | >98% by HPLC and SDS-PAGE |
Storage : | This lyophilized preparation is stable at 2-4 centigrade, but should be kept desiccated at -20 centigrade for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4 centigrade. For maximal stability, apportion the reco |
Reconstitution : | Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | DEFB4A defensin, beta 4A [ Homo sapiens ] |
Official Symbol : | DEFB4A |
Synonyms : | DEFB4A; defensin, beta 4A; DEFB2, DEFB4, DEFB102, defensin, beta 2 , defensin, beta 4; beta-defensin 4A; DEFB 2; HBD 2; SAP1; defensin, beta 2; defensin, beta 4; skin-antimicrobial peptide 1; BD-2; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102; |
Gene ID : | 1673 |
mRNA Refseq : | NM_004942 |
Protein Refseq : | NP_004933 |
MIM : | 602215 |
UniProt ID : | O15263 |
Chromosome Location : | 8p23.1 |
Pathway : | Beta defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
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DEFB4A-1064R | Recombinant Rhesus Macaque DEFB4A Protein, His (Fc)-Avi-tagged | +Inquiry |
DEFB4A-1333H | Recombinant Human DEFB4A Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionDEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.
Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.
The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.
Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.
The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.
There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.
Customer Reviews (3)
Write a reviewThe structure is very stable and not easy to deteriorate.
The cost is low and the activity is strong, which greatly saves our scientific research costs.
The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.
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