Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human DEFB4A protein

Cat.No. : DEFB4A-5192H
Product Overview : Recombinant Human DEFB4A, a single, non-glycosylated polypeptide chain containing 50 amino acids was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB, pH 7.4 + 130 mM NaCl.
Bio-activity : Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 100 ng/ml.Specific Activity: >1.0 × 10^4 IU/mg.
Molecular Mass : 6.0 kDa
Protein length : 50 amino acids
Endotoxin : Less than 1EU/μg as determined by LAL method.
Purity : >98% by HPLC and SDS-PAGE
Storage : This lyophilized preparation is stable at 2-4 centigrade, but should be kept desiccated at -20 centigrade for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4 centigrade. For maximal stability, apportion the reco
Reconstitution : Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Gene Name : DEFB4A defensin, beta 4A [ Homo sapiens ]
Official Symbol : DEFB4A
Synonyms : DEFB4A; defensin, beta 4A; DEFB2, DEFB4, DEFB102, defensin, beta 2 , defensin, beta 4; beta-defensin 4A; DEFB 2; HBD 2; SAP1; defensin, beta 2; defensin, beta 4; skin-antimicrobial peptide 1; BD-2; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102;
Gene ID : 1673
mRNA Refseq : NM_004942
Protein Refseq : NP_004933
MIM : 602215
UniProt ID : O15263
Chromosome Location : 8p23.1
Pathway : Beta defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can the structure of DEFB4A be evaluated? 05/25/2023

DEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.

Which biomolecules can be used as molecular markers for DEFB4A? 03/16/2023

Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.

What diseases are associated with the aberrant expression of DEFB4A? 07/26/2022

The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.

What are the treatment strategies for DEFB4A? 03/07/2021

Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.

How can I detect the expression level of DEFB4A? 11/15/2020

The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.

What is the interaction between DEFB4A and other biomolecules? 02/01/2020

There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.

Customer Reviews (3)

Write a review
Reviews
06/28/2023

    The structure is very stable and not easy to deteriorate.

    06/01/2023

      The cost is low and the activity is strong, which greatly saves our scientific research costs.

      04/09/2020

        The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.

        Ask a Question for All DEFB4A Products

        Required fields are marked with *

        My Review for All DEFB4A Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends