"IL1B" Related Products

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Recombinant Rhesus macaque Interleukin 1, Beta

Cat. No.: IL1B-559R
Product Overview: RecombinantRhesus Macaque IL1B is a single non-glycosylated polypeptide chain containing153 amino acids.
Description: IL1B is aproinflammatory cytokine produced in a variety of cells including monocytes,tissue macrophages, keratinocytes and other epithelial cells. IL1B bind tothe same receptor and have similar if not identical biological properties.These cytokines have a broad range of activities including, stimulation of thymocyteproliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenicFGF-like activity, and the ability to stimulate the release of prostaglandinand collagenase from synovial cells.
Source: Rhesus Macaque
Host: E. coli
Form: Lyophilized from a 0.2 um sterile filteredsolution of PBS, pH 7.4.
Purity: >98%by SDS-PAGE and HPLC analyses.
Sequence: APVRSLHCTLRDAQLKSLVM SGPYELKALH LQGQDLEQQV VFSMSFVQGE ESNDKIPVAL GLKAKNLYLS CVLKDDKPTLQLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTRGG QDITDFTMQFVSS
Molecular Weight: 17.3 kDa
Biological Activity: Fullybiologically active when compared to standard. The ED50 as determined by thedose-dependent stimulation of D10.G4.1 mouse helper T cells is typically 3-10pg/ml.
Endotoxin: < 0.1 ng/μg ofprotein.
Reconstitution: Centrifugevial prior to opening. Reconstitute in sterile distilled water or aqueousbuffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stocksolutions should be apportioned into working aliquots and stored at <-20°C.Further dilutions should be made in appropriate buffered solutions.
Storage: Thelyophilized protein is stable at 2-4°C, but should be kept desiccated at-20°C for long term storage. After reconstitution, the protein is stable for1 week at 2-4°C. For long term storage, aliquot and freeze at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol: IL1B
Pathways: Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; Africantrypanosomiasis; Alzheimer"s disease; Amoebiasis; Apoptosis; Chagas disease(American trypanosomiasis); Cytosolic DNA-sensing pathway; Graft-versus-hostdisease; Herpes simplex infection; Influenza A
Gene Name: IL1Binterleukin 1, beta [ Macaca mulatta ]
Synonyms: IL1B; interleukin1, beta; interleukin-1beta; IL-1 beta
Gene ID: 704701
mRNA Refseq: NM_001042756
Protein Refseq: NP_001036221
UniProt ID: P48090
Chromosome Location: 13

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