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| Cat. No.: | IL1B-559R |
| Product Overview: | RecombinantRhesus Macaque IL1B is a single non-glycosylated polypeptide chain containing153 amino acids. |
| Description: | IL1B is aproinflammatory cytokine produced in a variety of cells including monocytes,tissue macrophages, keratinocytes and other epithelial cells. IL1B bind tothe same receptor and have similar if not identical biological properties.These cytokines have a broad range of activities including, stimulation of thymocyteproliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenicFGF-like activity, and the ability to stimulate the release of prostaglandinand collagenase from synovial cells. |
| Source: | Rhesus Macaque |
| Host: | E. coli |
| Form: | Lyophilized from a 0.2 um sterile filteredsolution of PBS, pH 7.4. |
| Purity: | >98%by SDS-PAGE and HPLC analyses. |
| Sequence: | APVRSLHCTLRDAQLKSLVM SGPYELKALH LQGQDLEQQV VFSMSFVQGE ESNDKIPVAL GLKAKNLYLS CVLKDDKPTLQLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTRGG QDITDFTMQFVSS |
| Molecular Weight: | 17.3 kDa |
| Biological Activity: | Fullybiologically active when compared to standard. The ED50 as determined by thedose-dependent stimulation of D10.G4.1 mouse helper T cells is typically 3-10pg/ml. |
| Endotoxin: | < 0.1 ng/μg ofprotein. |
| Reconstitution: | Centrifugevial prior to opening. Reconstitute in sterile distilled water or aqueousbuffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stocksolutions should be apportioned into working aliquots and stored at <-20°C.Further dilutions should be made in appropriate buffered solutions. |
| Storage: | Thelyophilized protein is stable at 2-4°C, but should be kept desiccated at-20°C for long term storage. After reconstitution, the protein is stable for1 week at 2-4°C. For long term storage, aliquot and freeze at -80°C. Avoidrepeated freeze-thaw cycles. |
| OfficialSymbol: | IL1B |
| Pathways: | Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; Africantrypanosomiasis; Alzheimer"s disease; Amoebiasis; Apoptosis; Chagas disease(American trypanosomiasis); Cytosolic DNA-sensing pathway; Graft-versus-hostdisease; Herpes simplex infection; Influenza A |
| Gene Name: | IL1Binterleukin 1, beta [ Macaca mulatta ] |
| Synonyms: | IL1B; interleukin1, beta; interleukin-1beta; IL-1 beta |
| Gene ID: | 704701 |
| mRNA Refseq: | NM_001042756 |
| Protein Refseq: | NP_001036221 |
| UniProt ID: | P48090 |
| Chromosome Location: | 13 |
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