Il1b Protein

Il1b

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Il1b

Official Full Name interleukin 1 beta
Background Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
Synonyms Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Feline
    • Guinea pig
    • Horse
    • Human
    • Monkey
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cells
    • Mammalian Cell
    • Mammalian cells
    • Monkey
    • Rabbit
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • HIgG1 Fc
    • His
    • His&Myc
    • His(C-ter)
    • S
    • T7
    • His-SUMO
    • Met
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1B-027E Active Recombinant Human IL1B (117-269aa) E.coli N/A Inquiry
    Human IL1B-23H Active Recombinant Human IL1B E.coli N/A Inquiry
    Human IL1B-339H Active Recombinant Human IL1B Human N/A Inquiry
    Human IL1B-461H Active Recombinant Human Interleukin 1, Beta E.coli N/A Inquiry
    Human Il1B-464H Active Recombinant Human Il1B, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Human IL1B-465H Active Recombinant Human IL1B, MIgG2a Fc-tagged CHO Fc Inquiry
    Human IL1B-9908H Active Recombinant Human IL1B CHO N/A Inquiry
    Mouse Il1b-040E Active Recombinant Mouse Il1b (118-269aa), Met tagged E.coli N/A Inquiry
    Mouse Il1b-462M Active Recombinant Mouse Interleukin 1 Beta E.coli N/A Inquiry
    Mouse Il1b-603M Active Recombinant Mouse Il1b E.coli Met Inquiry
    Mouse Il1b-8899M Active Recombinant Mouse Il1b CHO N/A Inquiry
    Rat Il1b-463R Active Recombinant Rat Interleukin-1 beta E.coli N/A Inquiry
    Cynomolgus Monkey IL1B-1167C Active Recombinant Cynomolgus IL1B Protein E.coli N/A Inquiry
    Canine IL1B-656C Active Recombinant Canine IL1B E.coli N/A Inquiry
    Rabbit IL1B-667R Active Recombinant Rabbit IL1B E.coli N/A Inquiry
    Pig IL1B-1024P Active Recombinant Pig IL1B Protein E.coli N/A Inquiry
    Feline IL1B-1030F Active Recombinant Feline IL1B Protein E.coli N/A Inquiry
    Cotton Rat Il1b-390C Active Recombinant Cotton Rat Il1b, Met-tagged E.coli Met Inquiry
    Monkey IL1B-394M Active Recombinant Monkey Interleukin 1 Beta Monkey N/A Inquiry
    Mouse IL1b-01M Active Recombinant Mouse IL1b Protein, His-Tagged E.coli His Inquiry
    Porcine IL1B-01P Active GMP Recombinant Porcine IL1B Protein, His-Tagged E.coli His Inquiry
    Human IL1B-02H Recombinant Human IL1B protein E.coli N/A Inquiry
    Human IL1B-132H Recombinant Human IL1B Protein E. coli N/A Inquiry
    Human IL1B-134H Recombinant Human Interleukin 1, Beta, His-tagged E.coli His Inquiry
    Human IL1B-14167H Recombinant Human IL1B, GST-tagged E.coli GST Inquiry
    Human IL1B-321H Recombinant Human IL1B, His-tagged E.coli His Inquiry
    Human IL1B-460H Recombinant Human IL1B protein, His-tagged HEK293 His Inquiry
    Human Il1B-466H Recombinant Human Il1B, HIgG1 Fc-tagged CHO HIgG1 Fc Inquiry
    Human IL1B-60H Recombinant Human IL1B, His-tagged E.coli His Inquiry
    Human IL1B-744H Recombinant Human IL1B, His tagged E.coli His Inquiry
    Human IL1b-82H Recombinant Human IL-1 beta Yeast N/A Inquiry
    Mouse Il1b-04M Recombinant Mouse Il1b protein E.coli N/A Inquiry
    Mouse Il1b-105M Recombinant Mouse Interleukin 1 Beta, His-tagged E.coli His Inquiry
    Mouse Il1b-2830M Recombinant Mouse Il1b protein, His & GST-tagged E.coli His/GST Inquiry
    Mouse Il1b-2831M Recombinant Mouse Il1b protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Il1b-383M Recombinant Mouse Il1b, None tagged E.coli N/A Inquiry
    Mouse Il1b-509M Recombinant Mouse Il1b protein, His-tagged HEK293F His Inquiry
    Mouse IL1B-8135M Recombinant Mouse IL1B Protein Mammalian Cell His Inquiry
    Rat Il1b-384R Recombinant Rat Il1b, His tagged E.coli His Inquiry
    Rat IL1B-577R Recombinant Rat IL1B, His tagged E.coli His Inquiry
    Rat Il1b-93R Recombinant Rat Il1b protein E.coli N/A Inquiry
    Rhesus Macaque IL1B-2239R Recombinant Rhesus monkey IL1B Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus IL1B-559R Recombinant Rhesus IL1B protein E.coli N/A Inquiry
    Canine IL1B-243C Recombinant Canine Interleukin 1, Beta Yeast N/A Inquiry
    Canine Il1b-25C Recombinant Canine IL-1 beta Yeast N/A Inquiry
    Dog IL1B-2827D Recombinant Dog IL1B protein, His-tagged E.coli His Inquiry
    Bovine IL1B-232B Recombinant Bovine Interleukin 1, Beta Yeast N/A Inquiry
    Rabbit IL1B-2834R Recombinant Rabbit IL1B protein, His & T7-tagged E.coli His/T7 Inquiry
    Chicken IL1B-589C Recombinant Chicken Interleukin 1, Beta E.coli N/A Inquiry
    Chicken IL1B-6093C Recombinant Chicken IL1B Mammalian Cell His Inquiry
    Zebrafish IL1B-12106Z Recombinant Zebrafish IL1B Mammalian Cell His Inquiry
    Horse IL1B-251E Recombinant Horse IL1B protein E.coli N/A Inquiry
    Feline IL1B-259F Recombinant Feline Interleukin 1, Beta Yeast N/A Inquiry
    Cattle IL1B-2826C Recombinant Cattle IL1B protein, His & T7-tagged E.coli His/T7 Inquiry
    Horse IL1B-2828H Recombinant Horse IL1B protein, His-tagged E.coli His Inquiry
    Guinea pig Il1b-2829G Recombinant Guinea pig Il1b protein, His & S-tagged E.coli His/S Inquiry
    Sheep IL1B-2832S Recombinant Sheep IL1B protein, His & T7-tagged E.coli His/T7 Inquiry
    Pig IL1B-2833P Recombinant Pig IL1B protein, His-tagged E.coli His Inquiry
    Ovine IL1b-56O Recombinant Ovine IL-1 beta Yeast N/A Inquiry
    Pig IL1β-82P Recombinant Porcine Interleukin-1 beta E.coli N/A Inquiry
    Human IL1B-853HCL Recombinant Human IL1B cell lysate N/A Inquiry
    Human IL1B-059H Recombinant Human IL1B Protein E. coli Inquiry
    Human IL1B-05H Recombinant Human IL1B Protein, Pre-aliquoted E.coli Inquiry
    Rat Il1b-1019R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His Inquiry
    Rat Il1b-1020R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His Inquiry
    Chicken IL1B-1021C Recombinant Chicken IL1B Protein, His-tagged E.coli N-His Inquiry
    Cattle IL1B-1022C Recombinant Cattle IL1B Protein, His-tagged E.coli N-His Inquiry
    Human IL1B-150H Recombinant Human IL1B Protein E.coli Inquiry
    Mouse IL1B-151M Recombinant Mouse IL1B Protein E.coli Inquiry
    Rat IL1B-152R Recombinant Rat IL1B Protein E.coli Inquiry
    Mouse Il1b-161M Recombinant Active Mouse IL1B Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL1B-162H Recombinant Active Human IL1B Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Pig IL1B-163P Recombinant Active Pig IL1B Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL1B-2121H Recombinant Human IL1B protein, Fc-tagged HEK293 Fc Inquiry
    Cynomolgus IL1B-2166C Recombinant Cynomolgus IL1B protein, His-tagged E.coli His Inquiry
    Zebrafish il1b-2298Z Recombinant Zebrafish il1b Protein, His-tagged E.coli N-His Inquiry
    Human IL1B-29H Recombinant Human IL1B Protein, Animal Free Human cells Inquiry
    Human IL1B-3096H Recombinant Human IL1B protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Human IL1B-3097H Recombinant Human IL1B protein, GST-tagged E.coli GST Inquiry
    Sheep IL1B-3098S Recombinant Sheep IL1B protein, His-tagged E.coli His Inquiry
    Human IL1B-313HFL Recombinant Full Length Human IL1B Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Zebrafish il1b-3668Z Recombinant Zebrafish il1b protein, His-tagged E.coli His Inquiry
    Zebrafish il1b-3669Z Recombinant Zebrafish il1b protein, His&Myc-tagged E.coli His&Myc Inquiry
    Human IL1B-40H Recombinant Human IL1B Protein E.coli Inquiry
    Human IL1B-52H Recombinant Human IL1B Protein, GST-tagged E.coli GST Inquiry
    Mouse Il1b-5314M Recombinant Mouse Il1b protein, His-tagged E.coli His Inquiry
    Sheep IL1B-5445S Recombinant Sheep IL1B protein, His-tagged Yeast His Inquiry
    Human IL1B-69H Recombinant Human IL1B Protein E.coli Inquiry
    Human CAB11564RH Rabbit Anti-Human IL1B / IL1F2 Monoclonal Antibody Rabbit N/A Inquiry
    Human IL1B-102HG GMP Recombinant Human IL1B Protein E. coli Inquiry
    Human IL1B-364H Recombinant Human IL1B Protein Human Cells N/A Inquiry
    Human Il1B-39H Recombinant Human Il1B protein, low endotoxin E.coli Inquiry
    Human IL1B-4316HG GMP Recombinant Human IL1B protein E.coli N/A Inquiry
    Human IL1B-5955H Recombinant Human IL1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human IL1B-83H Human Interleukin-1 Beta (rDNA derived) Reference standard N/A Inquiry
    Mouse Il1b-100M Recombinant Mouse Il1b Protein E.coli Inquiry
    Mouse Il1b-101M Recombinant Mouse Il1b Protein E.coli Inquiry
    Mouse Il1b-102M Recombinant Mouse Il1b Protein E.coli Inquiry
    Mouse Il1b-103M Recombinant Mouse Il1b Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry
    Mouse Il1b-133M Mouse Interleukin-1 beta (rDNA derived) Reference standard N/A Inquiry
    Mouse Il1b-7238M Recombinant Mouse Il1b Protein, His-tagged E.coli His Inquiry
    Dog IL1B-019D Recombinant Dog IL1B Protein E. coli Inquiry
    Canine IL1B-920C Recombinant Canine IL1B Protein (Ala115-Ser266) E.coli N/A Inquiry
    Chicken IL1B-1782C Recombinant Chicken IL1B protein, His-tagged E.coli His Inquiry
    Pig IL1B-82P Recombinant Pig IL1B protein E.coli N/A Inquiry

    Il1b involved in several pathways and played different roles in them. We selected most pathways Il1b participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK10; GADD45AB; FGF10A; PPM1BB; MAP3K5; MEF2CA; PRKACBB; HSPA1B; MAP3K3; PLA2G4D
    Cytokine-cytokine receptor interaction Ccl27a; IL22RA2; CCL19B; IL20; CLCF1; THPO; IFNB; GM1987; TNFSF12; PF4V1
    NF-kappa B signaling pathway Ccl21c; SYK; CCL13; TNF; NFKBIA; CCL4L2; IRAK4; TRAF1; BCL2A1; CXCL12
    Apoptosis CASP10; CASP6L1; CASP2; CASP12; BNIP3L; CASP3A; FASLG; IKBKG; PRKAR2AB; PPP3CB
    Osteoclast differentiation TNFSF11; SPI1; SIRP-BETA; FHL2; MAPK12; NFATC1; RELA; CSF1R; NOX1; CYBA
    Toll-like receptor signaling pathway MAP2K2A; IFNB1; IKBKB; IFNA6; LY96; TRAF6; IFNA3; FOS; TICAM2; TLR5
    NOD-like receptor signaling pathway NAIP6; HSP90AA1; MAPK9; SGUT1; MAPK12B; CASP1; HSP90AB1; HSP90B1; TAB3; CXCL8B.3
    Cytosolic DNA-sensing pathway IFNPHI3; NFKBIAB; IRF7; IFNA6; MAVS; IFNA5; POLR3A; POLR2E; NFKBIA; POLR3D
    Hematopoietic cell lineage IL1R1; IL11RA2; CD24; HLA-DRA; IL6R; CD1B; ITGA3; EPOR; CSF3R; CD59A
    TNF signaling pathway MAPK12; NFKBIA; MMP14; MAP2K6; BCL3; PIK3CB; Ccl12; PIK3R1; IL15; TRADD
    Inflammatory mediator regulation of TRP channels PLA2G4C; PRKACA; BDKRB1; ACCN5; MAPK10; MAPK13; TRPV1; P2RY2; CALM1; PIK3R2
    Non-alcoholic fatty liver disease (NAFLD) MAP3K11; BID; NDUFC1; SDHD; CEBPA; UQCRC2; UQCRB; NDUFA4L2; CYCS; CASP8
    Type I diabetes mellitus Fasl; HLA-DPB1; INS2; FAS; H2-AA; GAD2; FASLG; Il2; IL1A; HLA-F
    Alzheimers disease PPP3CA; NDUFV2; NDUFA10; ERN1; SDHB; NDUFA4L2; GAPDH; CASP12; ATP2A2; APOE
    Prion diseases IL1B; C1QC; SOD1; C7; NCAM1; C8G; C1QA; FYN; PRNP; HSPA5
    Salmonella infection KLC4; DYNC1I1; CD14; CCL4L1; IL-8; IL8L1; KLC1B; PFN1; CDC42L; IL6
    Pertussis C3; C4BPA; Il23a; MAPK8; TNF; C5; MAPK10; CALM1; GM5077; NOS2
    Legionellosis NFKBIA; HSPA1B; NAIP1; BCL2L13; NFKB2; MYD88; SAR1A; HSPA2; EEF1G; ITGB2
    Leishmaniasis ELK1; IL4; STAT1; IL1A; TGFB2; FCGR1A; C3; TGFB3; NOS2; MAP3K7
    Chagas disease (American trypanosomiasis) IL-8; PIK3CB; PIK3CA; IL12A; FASLG; PPP2R1A; PIK3CD; TLR2; MAPK12; TNF
    African trypanosomiasis PLCB1; LAMA4; IDO2; IL18; HBA1; Fasl; THOP1; HBB-B1; IL10; PLCB4
    Malaria TGFB3; HBB-B1; ICAM1; HBB-B2; IL1B; ITGB2; THBS3; MET; KLRK1; SDC1
    Amoebiasis IL6; SERPINB10; COL4A6; TGFB1; PIK3CA; ADCY1; GNAS; PIK3CG; RELA; COL4A3
    Tuberculosis SPHK2; HLA-DQB1; RAF1; PPP3R1; RAB7A; CD209; HLA-DQA2; LSP1; RAB5C; CASP9
    Measles IL1B; PIK3R1; MAVS; DDX58; IFNA17; EIF3H; TBK1; TRP53; EIF2AK4; CBLB
    Influenza A IFNA5; HLA-DQA2; FURIN; TNFRSF10A; TNF; SLC25A6; TNFRSF1A; FASLG; MX1; IFNA17
    Herpes simplex infection EIF2AK3; TRAF5; TAF9B; PKZ; TNF; HLA-DMA; FOS; PPP1CC; MYD88; PTPN11A
    Inflammatory bowel disease (IBD) IL17F; Il2; HLA-DOA; IL12RB2; HLA-DOB; HLA-DRB1; IL12A; H2-AA; STAT3; IL1B
    Rheumatoid arthritis MMP1; CXCL6; HLA-DOB; CXCL12; ATP6V0A4; HLA-DMB; TNFSF11; HLA-DRB1; ICAM1; CCL3L3
    Graft-versus-host disease HLA-B; HLA-E; HLA-DRB5; HLA-A; HLA-DQA1; HLA-DQA2; KLRC1; HLA-DQB1; HLA-DMA; FAS

    Il1b has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1b itself. We selected most functions Il1b had, and list some proteins which have the same functions with Il1b. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IFNB1; GDF6B; GDF7; WNT2; Cxcl15; CXCL9; IFNA4; AIMP1; TNFSF11; CTF1
    interleukin-1 receptor binding IL36G; TLR5; IL36RN; IL1F10; IL36B; IL1RN; IRAK4; IRAK1; TRIP6; IL1RAP
    protein domain specific binding RXRA; YWHAG; RAB6A; NR0B2; RUNX2; HOMER3; E2F4; ARFIP2; MTOR; TJP2

    Il1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1b.

    IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).

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