il1b
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  • Official Full Name
  • interleukin 1 beta
  • Background
  • Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
  • Synonyms
  • Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA
Cat.#:IL1B-132HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B Protein
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Cat.#:IL1B-461HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta
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Cat.#:Il1b-462MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 1 Beta
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Cat.#:Il1b-463RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin-1 beta
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Cat.#:IL1B-14167HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, GST-tagged
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Cat.#:IL1B-23HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B
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Cat.#:Il1B-464HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1B, HIgG1 Fc-tagged, mutant
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Cat.#:IL1B-465HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL1B, MIgG2a Fc-tagged
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Cat.#:Il1B-466HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1B, HIgG1 Fc-tagged
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Cat.#:IL1B-60HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His-tagged
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Cat.#:IL1B-744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His tagged
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Cat.#:IL1b-82HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-1 beta
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Cat.#:IL1B-9908HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL1B
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Cat.#:Il1b-2830MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His & GST-tagged
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Cat.#:Il1b-2831MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His & T7-tagged
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Cat.#:Il1b-383MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b, None tagged
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Cat.#:Il1b-509MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His-tagged
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Cat.#:Il1b-603MTag:Met
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b
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Cat.#:IL1B-8135MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL1B Protein
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Cat.#:Il1b-8899MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il1b
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Cat.#:Il1b-384RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1b, His tagged
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Cat.#:IL1B-577RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat IL1B, His tagged
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Cat.#:IL1B-1167CTag:
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL1B Protein
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Cat.#:IL1B-2239RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL1B Protein, His-tagged
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Cat.#:Il1b-25CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-1 beta
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Cat.#:IL1B-2827DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL1B protein, His-tagged
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Cat.#:IL1B-656CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL1B
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Cat.#:IL1B-1782CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL1B protein, His-tagged
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Cat.#:IL1B-2834RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1B protein, His & T7-tagged
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Cat.#:IL1B-6093CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL1B
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Cat.#:IL1B-667RTag:
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1B
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Cat.#:IL1B-12106ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL1B
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Cat.#:IL1B-1024PTag:
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1B Protein
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Cat.#:IL1B-1030FTag:
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline IL1B Protein
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Cat.#:IL1B-2826CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL1B protein, His & T7-tagged
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Cat.#:IL1B-2828HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse IL1B protein, His-tagged
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Cat.#:Il1b-2829GTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Il1b protein, His & S-tagged
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Cat.#:IL1B-2832STag:His/T7
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep IL1B protein, His & T7-tagged
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Cat.#:IL1B-2833PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1B protein, His-tagged
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Cat.#:Il1b-390CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il1b, Met-tagged
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Cat.#:IL1b-56OTag:
Source (Host):YeastSpecies:Ovine
Product nameRecombinant Ovine IL-1 beta
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Cat.#:IL1B-027ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B (117-269aa)
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Cat.#:IL1B-321HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His-tagged
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Cat.#:IL1B-339HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B
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Cat.#:Il1b-040ETag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b (118-269aa), Met tagged
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Cat.#:IL1B-559RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus macaque Interleukin 1, Beta
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Cat.#:IL1B-589CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Interleukin 1, Beta
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Cat.#:IL1B-394MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Interleukin 1 Beta
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Cat.#:IL1B-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta
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Cat.#:IL1B-134HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta, His-tagged
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Cat.#:Il1b-04MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-1 Beta
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Cat.#:Il1b-105MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 1 Beta, His-tagged
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Cat.#:Il1b-93RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 1 beta
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Cat.#:IL1B-243CTag:N/A
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine Interleukin 1, Beta
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Cat.#:IL1B-232BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 1, Beta
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Cat.#:IL1B-251ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 1, Beta
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Cat.#:IL1B-259FTag:N/A
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline Interleukin 1, Beta
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Cat.#:IL1β-82PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Interleukin-1 beta
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Cat.#:IL1B-853HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL1B cell lysate
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Cat.#:IL1B-4316HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL1B protein
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Cat.#:IL1B-83HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-1 Beta (rDNA derived) Reference standard
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Cat.#:Il1b-133MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-1 beta (rDNA derived) Reference standard
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Cat.#:CSC-P0141Tag:
Source (Host):Species:
Product nameAnti-Human IL1 beta F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0142Tag:
Source (Host):Species:
Product nameAnti-Human IL1 beta scFv Stable Cell Line-CHO
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Involved Pathway

Il1b involved in several pathways and played different roles in them. We selected most pathways Il1b participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GNA12A; NLK2; MAPK8A; TRAF6; NFATC1; CACNA2D1A; TP53; CACNA1DA; MAP2K2A; MAP3K12
Cytokine-cytokine receptor interaction
CCR1L1; TNFRSF18; ACVR2AA; IFNA13; IFNB1; IL10; IL4R; IL12RB2; LEPB; CD40LG
NF-kappa B signaling pathway
PIDD1; CFLAR; LBP; BCL2L1; DDX58; PLAU; LTA; SYK; TRAF1; CCL21B
Apoptosis
CYCSB; DFFB; PIK3R3B; PIK3CD; CLSPN; CYCS; AIFM1; CRADD; BCL2L11; NFKBIAB
Osteoclast differentiation
LILRA5; RAC1; FCGR3A; IFNG; NCF2; MAPK3; GAB2; PPP3CA; FOSL2; TEC
Toll-like receptor signaling pathway
CXCL10; IFNA6; IL8L2; TAB2; IFNB1; TNF; CRFB2; AKT2L; PIK3R3A; NFKBIAA
NOD-like receptor signaling pathway
PSTPIP1A; CXCL2; CASP1; CASPA; ERBB2IP; NAIP7; MAPK3; IL6; NFKBIB; LOC100033925
Cytosolic DNA-sensing pathway
POLR3A; POLR2E; IKBKE; IL6; POLR2L; Ifna15; TMEM173; MB21D1; CXCL10; POLR2H
Hematopoietic cell lineage
IL1B; GP5; IL5RA; CD8B1; ITGA2B; CD19; GM-CSF; IL6R; CD37; HLA-DRB4
TNF signaling pathway
TRAF3; IL6; MAP2K3; LIF; TRAF1; CCL20; CCL5; CREB3L3; MAP2K6; CXCL2
Inflammatory mediator regulation of TRP channels
GNAQ; ASIC4; TRPV1; TRPV3; IL1B; IL1RAP; TRPV4; PIK3CA; PPP1CA; PLCB1
Non-alcoholic fatty liver disease (NAFLD)
SDHB; PRKAB2; ERN1; GSK3A; IL6; NDUFB3; ATF4; CDC42; NDUFS3; PRKAA1
Type I diabetes mellitus
HLA-DOB; HLA-DRB1; PTPRN; HLA-DQB1; INS1; TNF; IL12A; HLA-DRA; GZMB; CD28
Alzheimers disease
GRIN2A; SNCA; NDUFA4L2; HSD17B10; NDUFS3; ADAM10; NCSTN; NDUFS1; PPP3R2; NDUFB6
Prion diseases
PRKACG; MAP2K1; C1QB; C8B; MAPK1; HSPA1A; LOC100033925; Hc; HSPA5; MAP2K2
Salmonella infection
IL6; ROCK2; NOS2; MAPK14A; RELA; NOS2A; RAC1; RAB7A; CD14; RAB7
Pertussis
CASP7; IL12A; TNF; IL1B; C4BP; MAPK3; IL12B; C5; CASP1; Casp3
Legionellosis
SAR1A; CXCL2; VCP; CXCL3; ITGB2L; RAB1A; CASP9; HSF1; IL-8; HSPA6
Leishmaniasis
ITGB2L; NFKB1; CYBA; NCF1; HLA-DOB; C3; HLA-DOA; TLR2; IL1A; MAPK13
Chagas disease (American trypanosomiasis)
PIK3CA; MAPK10; TLR2; FAS; C1QA; MAPK8; NFKBIA; CALR; FADD; CCL3L3
African trypanosomiasis
TNF; FAS; VCAM1; IL12A; LAMA4; APOA1; PRKCB; Fasl; IFNG; IL6
Malaria
IL6; MET; TGFB2; HGF; Ccl12; HBB-B1; THBS4; GYPC; PECAM1; ITGB2
Amoebiasis
GNA14; TGFB3; PIK3CA; RAB7A; SERPINB13; ARG1; IL12A; SERPINB2; PLCB3; LAMC3
Tuberculosis
TNF; IL18; MAPK13; RELA; IFNA21; MAPK11; BCL2; RIPK2; RFXAP; Pla2r1
Measles
CD3E; Ifna15; IRAK4; CCND2; AKT2; IL2RB; TNFAIP3; IL12B; STAT5B; IFNGR1
Influenza A
AKT2; BLB2; FAS; IL1B; PABPN1; HSPA1L; SOCS3; MAP2K3; TMPRSS13; OAS1
Herpes simplex infection
MYD88; MAPK8; ARNTL; SRPK1; PILRA; CUL1A; CDC34A; PKZ; C1QBP; GLTSCR2
Inflammatory bowel disease (IBD)
HLA-DQB1; STAT6; NFKB1; IL12RB1; IL18; IL21R; TGFB3; IFNGR1; IL17A; HLA-DOB
Rheumatoid arthritis
CD80; HLA-DMA; ATP6V1G2; VEGFA; ITGB2; ATP6V1D; ICAM1; MMP1; IL1B; HLA-DMB
Graft-versus-host disease
HLA-DOB; IFNG; HLA-B; KLRD1; H2-AA; HLA-DRB3; PRF1; HLA-DOA; HLA-DPA1; HLA-G

Protein Function

Il1b has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1b itself. We selected most functions Il1b had, and list some proteins which have the same functions with Il1b. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein HMGB1; IFNA14; WNT7A; IFNG1-2; IFNA4; FLT3LG; OSTN; IL6; CTF1; TXLNA
Function interleukin-1 receptor binding
Related Protein TLR5; Il1f6; IL37; IL1A; IRAK4; TLR9; IRAK1; IL36B; IL1F10; IL1RN
Function protein domain specific binding
Related Protein YWHABL; SCAF1; MPP7; HIST1H4L; NDE1; TNFAIP1; AKAP5; CALM2; NEFL; HIST1H4F

Interacting Protein

Il1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1b.
IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

Il1b Related Articles

McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).