IL1B
-
Official Full Name
interleukin 1 beta
-
Overview
Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra). -
Synonyms
Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Transfected Stable Cell Lines
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Ala117-Ser268
- Bovine
- Canine
- Cattle
- Chicken
- Cotton Rat
- Cynomolgus
- Cynomolgus Monkey
- Dog
- Feline
- Golden hamster
- Guinea pig
- Horse
- Human
- Monkey
- Mouse
- Ovine
- Pig
- Porcine
- Rabbit
- Rat
- Rhesus
- Rhesus Macaque
- Sheep
- Zebrafish
- C-His
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human cells
- Human Cells
- Mammalian Cell
- Mammalian cells
- Monkey
- Rabbit
- Yeast
- C
- Flag
- His
- Avi
- Fc
- GST
- Myc
- S
- Strep II
- SUMO
- T7
- DDK
- Non
- Trx
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL1B involved in several pathways and played different roles in them. We selected most pathways IL1B participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF10;CACNA1SA;FGF12;HRASA;RPS6KA4;FGF11;RAF1B;MAP2K1;RAP1A |
| Cytokine-cytokine receptor interaction | GM2506;CCR9;IL24;IL13RA1;FASLG;Cxcl15;ACKR3B;CCL20A.3;LOC100033925 |
| NF-kappa B signaling pathway | TRAF6;LY96;IKBKG;TNFRSF11A;TNFAIP3;CCL13;PRKCQ;RELA;IKBKB |
| Apoptosis | TNFSF10;GZME;TNFRSFA;FADD;DIABLOB;PIK3CG;TNFRSF10A;IRF2;ATM |
| Osteoclast differentiation | TNFRSF11B;OSCAR;PPP3CB;BLNK;SIRPA;FYN;MAPK8;NOX1;MAP2K7 |
| Toll-like receptor signaling pathway | TLR7;IFNA2;AKT2;RAC1B;PIK3CD;TLR8;MAP2K6;CXCL9;PIK3R3A |
| NOD-like receptor signaling pathway | PSTPIP1A;CXCL2;PSTPIP1;HSP90AA1.1;RIPK2;IKBKB;MAPK11;CASP8;LOC100033925 |
| Cytosolic DNA-sensing pathway | IFNA14;CASP1;IL18;IFNA8;POLR3D;POLR3GL;AIM2;IKBKG;RELA |
| Hematopoietic cell lineage | CSF3;CD14;CD44;ITGA6;IL1B;GP1BB;IL7;CD8A;TNF |
| TNF signaling pathway | MAP2K7;MMP14;MLKL;MMP9;MAPK10;Ccl12;MAPK12;BCL3;MAPK1 |
| Inflammatory mediator regulation of TRP channels | TRPA1;PIK3CD;CYP2C54;ASIC5;PLCG1;ACCN3;MAPK8;BDKRB1;PIK3R3 |
| Non-alcoholic fatty liver disease (NAFLD) | EIF2AK3;NDUFA9;INS;FASLG;NDUFB5;NDUFB8;INSR;SDHC;COX7A2 |
| Type I diabetes mellitus | LTA;IL12A;HLA-DRB3;HLA-DRB5;HLA-G;Il2;IFNG;IL1A;HLA-DQA2 |
| Alzheimers disease | GRIN2D;UQCR10;CAPN2;ATP5E;PLCB1;GRIN2B;ATP5B;APH1B;NDUFA13 |
| Prion diseases | C1QA;IL1A;C7;STIP1;PRKACG;SOD1;LOC100033925;MAP2K2;C8A |
| Salmonella infection | ACTB1;CXCL8B.3;ACTB2;CCL4L1;CASPA;IL18;PKN1;CCL4L2;RAB7 |
| Pertussis | C4A;MAPK13;CXCL5;IL1A;CALML3;Casp3;Itgam&Itgb2;GNAI2;RELA |
| Legionellosis | MYD88;CASP7;HSPA2;HSF1;NFKBIA;NFKB2;NFKB1;NLRC4;PYCARD |
| Leishmaniasis | NFKBIA;HLA-DQB1;MAPK1;FCGR4;NFKB1;HLA-DRB3;IRAK1;HLA-DRB4;FOS |
| Chagas disease (American trypanosomiasis) | CD3E;TNF;GNAO1;MAPK9;IL6;TLR4;CD3G;TRAF6;TGFB1 |
| African trypanosomiasis | FAS;HBA-A2;THOP1;IFNG;MYD88;HBB;PLCB4;APOA1;HBA1 |
| Malaria | ITGB2;CSF3;HBB;THBS2;CD40LG;HBA2;HBA-A2;SDC1;CCL2 |
| Amoebiasis | CD1D;PRKACB;IL-8;SERPINB13;SERPINB3;RAB7B;LAMA1;SERPINB9;GNA14 |
| Tuberculosis | TLR9;IL10RA;CD209C;MRC2;LAMP2;BCL10;RHOA;NFYB;IFNA8 |
| Measles | IFNA4;IL1A;Ifna15;NFKBIB;STAT5A;TACR1;IFNA6;TBK1;DDX58 |
| Influenza A | HSPA6;CPSF4;NFKBIA;AGFG1;PML;MAP2K6;BCL2L2-PABPN1;KPNA2;STAT1 |
| Herpes simplex infection | SRSF4;PVRL2;OAS1B;IFNPHI1;PER3;SRSF6A;HLA-C;IFNPHI3;SRSF2B |
| Inflammatory bowel disease (IBD) | HLA-DOA;IL21;TGFB2;IL23;IFNGR1;IL22;IL4R;STAT6;IL5 |
| Rheumatoid arthritis | VEGFA;ATP6V0B;ATP6V0A2;LTB;HLA-DRB3;TNFSF13B;Ctsl;TNF;ATP6V1H |
| Graft-versus-host disease | Fasl;H2-AA;HLA-DQA1;Il2;FAS;CD80;GZMB;HLA-DRA;H2-Q10 |
IL1B has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1B itself. We selected most functions IL1B had, and list some proteins which have the same functions with IL1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GDF6B;CMTM5;IL6;HMGB1;MSTN;IL1RN;LEFTY2;NRG1;IFNA21 |
| interleukin-1 receptor binding | IL36A;TLR5;IL37;IRAK4;IRAK1;IL1F10;IL36G;Il1f6;TRIP6 |
| protein domain specific binding | GABRR3;FOXH1;CHMP2A;EHD2;CNTLN;MITD1;ZNF521;ARHGEF4;PPP3R1 |
IL1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1B.
IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewEffective in inflammation studies.
High specificity.
Suitable for cytokine assays.
Q&As (10)
Ask a questionInflammasome assembly initiated by IL-1β is deciphered using techniques like co-immunoprecipitation, proximity ligation assays, and super-resolution microscopy.
IL-1β's priming of immune cells is dissected through flow cytometry, RNA sequencing, and chromatin immunoprecipitation, revealing its epigenetic and transcriptional effects.
Mass spectrometry-based phosphoproteomics deciphers IL-1β's post-translational modifications, revealing regulatory sites crucial for its activation and signaling.
Bioinformatics tools integrate multi-omics data to provide a comprehensive understanding of IL-1β's roles, revealing its intricate contributions to health and disease.
ChIP-seq and DNA methylation profiling uncover IL-1β's epigenetic impact on target genes, shedding light on its role in shaping chronic inflammatory states.
IL-1β's interactions with downstream effectors are unveiled using dual-luciferase reporter assays, surface plasmon resonance, and co-crystallization studies.
Network analysis integrates omics data to unravel IL-1β's intricate cross-talk with other cytokines, mapping out complex regulatory loops in inflammation.
IL-1β's impact on the tumor microenvironment is studied using intravital microscopy, 3D culture models, and single-cell RNA sequencing to capture dynamic cell behavior.
CRISPR-Cas9 screening identifies IL-1β's non-canonical signaling mediators through functional genomics, revealing alternative pathways in cellular responses.
Single-cell RNA sequencing unveils IL-1β's context-specific responses, exposing cell type-specific signaling and gene expression patterns.
Ask a Question for All IL1B Products
Required fields are marked with *
My Review for All IL1B Products
Required fields are marked with *
