• Official Full Name

    interleukin 1 beta

  • Background

    Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
  • Synonyms

    Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA;
    • Type:
    • Recombinant Proteins
    • Transfected Stable Cell Lines
    • GMP Proteins
    • Cell & Tissue Lysates
    • Antibody
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Feline
    • Guinea pig
    • Horse
    • Human
    • Monkey
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human cells
    • Human Cells
    • Mammalian Cell
    • Monkey
    • Rabbit
    • Yeast
    • Tag :
    • Fc
    • GST
    • HIgG1 Fc
    • His
    • His (Fc)
    • Avi
    • Myc
    • His(C
    • ter)
    • His|GST
    • His|S
    • His|T7
    • SUMO
    • Met
    • DDK
    • MYC
    • N/A
    • N
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine IL1B-232B Recombinant Bovine Interleukin 1, Beta Yeast N/A
    Canine IL1B-920C Recombinant Canine IL1B Protein (Ala115-Ser266) E.coli N/A
    Canine Il1b-25C Recombinant Canine IL-1 beta Yeast N/A
    Canine IL1B-656C Active Recombinant Canine IL1B E.coli N/A
    Canine IL1B-243C Recombinant Canine Interleukin 1, Beta Yeast N/A
    Cattle IL1B-2826C Recombinant Cattle IL1B protein, His & T7-tagged E.coli His/T7
    Cattle IL1B-1022C Recombinant Cattle IL1B Protein, His-tagged E.coli N-His
    Chicken IL1B-589C Recombinant Chicken Interleukin 1, Beta E.coli N/A
    Chicken IL1B-1021C Recombinant Chicken IL1B Protein, His-tagged E.coli N-His
    Chicken IL1B-1782C Recombinant Chicken IL1B protein, His-tagged E.coli His
    Chicken IL1B-6093C Recombinant Chicken IL1B Mammalian Cell His
    Cotton Rat Il1b-390C Active Recombinant Cotton Rat Il1b, Met-tagged E.coli Met
    Cynomolgus IL1B-2166C Recombinant Cynomolgus IL1B protein, His-tagged E.coli His
    Cynomolgus Monkey IL1B-1167C Active Recombinant Cynomolgus IL1B Protein E.coli N/A
    Dog IL1B-2827D Recombinant Dog IL1B protein, His-tagged E.coli His
    Dog IL1B-019D Recombinant Dog IL1B Protein E. coli
    Feline IL1B-1030F Active Recombinant Feline IL1B Protein E.coli N/A
    Feline IL1B-259F Recombinant Feline Interleukin 1, Beta Yeast N/A
    Guinea pig Il1b-2829G Recombinant Guinea pig Il1b protein, His & S-tagged E.coli His/S
    Horse IL1B-251E Recombinant Horse IL1B protein E.coli N/A
    Horse IL1B-2828H Recombinant Horse IL1B protein, His-tagged E.coli His
    Human IL1B-027E Active Recombinant Human IL1B (117-269aa) E.coli N/A
    Human IL1B-460H Recombinant Human IL1B protein, His-tagged HEK293 His
    Human IL1B-29H Recombinant Human IL1B Protein, Animal Free Human cells
    Human IL1B-83H Human Interleukin-1 Beta (rDNA derived) Reference standard N/A
    Human IL1B-14167H Recombinant Human IL1B, GST-tagged E.coli GST
    Human IL1b-82H Recombinant Human IL-1 beta Yeast N/A
    Human IL1B-28HG Recombinant Human IL1B Protein (Ala117-Ser269), GMP Grade, Animal-Free E.coli
    Human Il1B-466H Recombinant Human Il1B, HIgG1 Fc-tagged CHO HIgG1 Fc
    Human IL1B-60H Recombinant Human IL1B, His-tagged E.coli His
    Human IL1B-339H Active Recombinant Human IL1B Human N/A
    Human IL1B-059H Recombinant Human IL1B Protein E. coli
    Human Il1B-464H Active Recombinant Human Il1B, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL1B-461H Active Recombinant Human Interleukin 1, Beta E.coli N/A
    Human IL1B-853HCL Recombinant Human IL1B cell lysate N/A
    Human IL1B-05H Recombinant Human IL1B Protein, Pre-aliquoted E.coli
    Human IL1B-744H Recombinant Human IL1B, His tagged E.coli His
    Human IL1B-364H Recombinant Human IL1B Protein Human Cells N/A
    Human IL1B-321H Recombinant Human IL1B, His-tagged E.coli His
    Human CAB11564RH Rabbit Anti-Human IL1B / IL1F2 Monoclonal Antibody Rabbit N/A
    Human IL1B-102HG GMP Recombinant Human IL1B Protein E. coli
    Human IL1B-132H Recombinant Human IL1B Protein E. coli N/A
    Human IL1B-465H Active Recombinant Human IL1B, MIgG2a Fc-tagged CHO Fc
    Human IL1B-9908H Active Recombinant Human IL1B CHO N/A
    Human IL1B-2121H Recombinant Human IL1B protein, Fc-tagged HEK293 Fc
    Human IL1B-4316HG GMP Recombinant Human IL1B protein E.coli N/A
    Human IL1B-02H Recombinant Human IL1B protein E.coli N/A
    Human IL1B-23H Active Recombinant Human IL1B E.coli N/A
    Human IL1B-162H Recombinant Active Human IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL1B-52H Recombinant Human IL1B Protein, GST-tagged E.coli GST
    Human Il1B-39H Recombinant Human Il1B protein, low endotoxin E.coli
    Human IL1B-134H Recombinant Human Interleukin 1, Beta, His-tagged E.coli His
    Human IL1B-150H Recombinant Human IL1B Protein E.coli
    Human IL1B-3097H Recombinant Human IL1B protein, GST-tagged E.coli GST
    Human IL1B-5955H Recombinant Human IL1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL1B-40H Recombinant Human IL1B Protein E.coli
    Human IL1B-69H Recombinant Human IL1B Protein E.coli
    Human IL1B-1170H Recombinant Human IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL1B-3096H Recombinant Human IL1B protein, His-SUMO-tagged E.coli His-SUMO
    Human IL1B-1170H-B Recombinant Human IL1B Protein Pre-coupled Magnetic Beads HEK293
    Human IL1B-101I Recombinant Human IL1B Protein (153 aa) E.coli
    Human IL1B-1602H Recombinant Human IL1B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL1B-250I Recombinant Human IL1B Protein CHO
    Human IL1B-0849H Recombinant Human IL1B Protein (A117-S269), Tag Free E.coli No tag
    Human IL1B-366I Recombinant Human IL1B Protein (153 aa) E.coli
    Human IL1B-0850H Recombinant Human IL1B Protein (A117-S269), His tagged E.coli His
    Monkey IL1B-394M Active Recombinant Monkey Interleukin 1 Beta Monkey N/A
    Mouse IL1B-4503M-B Recombinant Mouse IL1B Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il1b-040E Active Recombinant Mouse Il1b (118-269aa), Met tagged E.coli N/A
    Mouse IL1B-151M Recombinant Mouse IL1B Protein E.coli
    Mouse Il1b-8899M Active Recombinant Mouse Il1b CHO N/A
    Mouse IL1B-1603M Recombinant Mouse IL1B protein, His-tagged E.coli His
    Mouse Il1b-383M Recombinant Mouse Il1b protein E.coli N/A
    Mouse Il1b-161M Recombinant Active Mouse IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il1b-2831M Recombinant Mouse Il1b protein, His & T7-tagged E.coli His/T7
    Mouse Il1b-102M Recombinant Mouse Il1b Protein E.coli
    Mouse IL1B-8135M Recombinant Mouse IL1B Protein Mammalian Cell His
    Mouse Il1b-7238M Recombinant Mouse Il1b Protein, His-tagged E.coli His
    Mouse Il1b-103M Recombinant Mouse Il1b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il1b-5314M Recombinant Mouse Il1b protein, His-tagged E.coli His
    Mouse Il1b-603M Active Recombinant Mouse Il1b E.coli Met
    Mouse Il1b-462M Active Recombinant Mouse Interleukin 1 Beta E.coli N/A
    Mouse IL1B-4503M Recombinant Mouse IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il1b-030I Recombinant Mouse Il1b Protein (153 aa) E.coli
    Mouse IL1b-01M Active Recombinant Mouse IL1b Protein, His-Tagged E.coli His
    Mouse Il1b-105M Recombinant Mouse Interleukin 1 Beta, His-tagged E.coli His
    Mouse Il1b-249I Recombinant Mouse Il1b Protein CHO
    Mouse Il1b-133M Mouse Interleukin-1 beta (rDNA derived) Reference standard N/A
    Mouse Il1b-365I Recombinant Mouse Il1b Protein (153 aa) E.coli
    Mouse Il1b-04M Recombinant Mouse Il1b protein E.coli N/A
    Mouse Il1b-509M Recombinant Mouse Il1b protein, His-tagged HEK293F His
    Mouse Il1b-2830M Recombinant Mouse Il1b protein, His & GST-tagged E.coli His/GST
    Mouse Il1b-100M Recombinant Mouse Il1b Protein E.coli
    Mouse Il1b-101M Recombinant Mouse Il1b Protein E.coli
    Ovine IL1b-56O Recombinant Ovine IL-1 beta Yeast N/A
    Pig IL1B-1024P Active Recombinant Pig IL1B Protein E.coli N/A
    Pig IL1B-2833P Recombinant Pig IL1B protein, His-tagged E.coli His
    Pig IL1B-82P Recombinant Pig IL1B protein E.coli N/A
    Pig IL1B-364I Recombinant Pig IL1B Protein (154 aa) E.coli
    Pig IL1B-163P Recombinant Active Pig IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Pig IL1β-82P Recombinant Porcine Interleukin-1 beta E.coli N/A
    Porcine IL1B-01P Active GMP Recombinant Porcine IL1B Protein, His-Tagged E.coli His
    Rabbit IL1B-2834R Recombinant Rabbit IL1B protein, His & T7-tagged E.coli His/T7
    Rabbit IL1B-667R Active Recombinant Rabbit IL1B E.coli N/A
    Rat Il1b-463R Active Recombinant Rat Interleukin-1 beta E.coli N/A
    Rat Il1b-93R Recombinant Rat Il1b protein E.coli N/A
    Rat Il1b-384R Recombinant Rat Il1b, His tagged E.coli His
    Rat IL1B-577R Recombinant Rat IL1B, His tagged E.coli His
    Rat Il1b-1019R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His
    Rat Il1b-180I Recombinant Rat Il1b Protein HEK293
    Rat Il1b-1020R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His
    Rat Il1b-363I Recombinant Rat Il1b Protein (152 aa) E.coli
    Rat IL1B-152R Recombinant Rat IL1B Protein E.coli
    Rhesus IL1B-1167R Active Active Recombinant Rhesus IL1B Protein E.coli N/A
    Rhesus IL1B-559R Recombinant Rhesus IL1B protein E.coli N/A
    Rhesus Macaque IL1B-2239R Recombinant Rhesus monkey IL1B Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL1B-2060R-B Recombinant Rhesus Macaque IL1B Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL1B-2060R Recombinant Rhesus Macaque IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Sheep IL1B-2832S Recombinant Sheep IL1B protein, His & T7-tagged E.coli His/T7
    Sheep IL1B-5445S Recombinant Sheep IL1B protein, His-tagged Yeast His
    Sheep IL1B-3098S Recombinant Sheep IL1B protein, His-tagged E.coli His
    Zebrafish il1b-2298Z Recombinant Zebrafish il1b Protein, His-tagged E.coli N-His
    Zebrafish il1b-3668Z Recombinant Zebrafish il1b protein, His-tagged E.coli His
    Zebrafish il1b-3669Z Recombinant Zebrafish il1b protein, His&Myc-tagged E.coli His&Myc
    Zebrafish IL1B-12106Z Recombinant Zebrafish IL1B Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL1B Related Articles
    • IL1B Related Research Area

    IL1B involved in several pathways and played different roles in them. We selected most pathways IL1B participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayTNF;NLK1;SOS1;MAP2K5;Fgf15;PRKACB;GNA12;RELA;NFATC3
    Cytokine-cytokine receptor interactionIFNA21;TNFRSF17;CCL7;IL18RAP;IL10;Ifnlr1;TNFRSF18;KIT;KDRL
    NF-kappa B signaling pathwayCCL4;TRIM25;PRKCQ;CCL21B;TNFSF14;LTB;VCAM1;TRAF5;DDX58
    Osteoclast differentiationTRAF2;SYK;PIK3CA;NFKB2;PIK3R1;CALCR;TEC;TNFRSF1A;PIK3CG
    Toll-like receptor signaling pathwayIL12B;CD14;TBK1;MAPK12B;TLR5B;TOLLIP;IFNB;IRAK4;CCL4
    NOD-like receptor signaling pathwayIL-8;RIPK2;NAIP7;CXCL8B.3;MAPK12A;NAIP6;NLRC4;MAPK8;MAPK13
    Cytosolic DNA-sensing pathwayIL18;POLR3A;LOC100033925;NFKBIAB;DDX58;IFNA8;IFNA2;IFNA16;POLR3B
    Hematopoietic cell lineageIL11RA2;ITGA2B;IL11RA;ITGA1;GP1BA;Cd24a;ITGB3;ANPEP;GP9
    Inflammatory mediator regulation of TRP channelsCYP2C39;PRKCD;Adcy4;CYP4A12A;ITPR3;CYP2J5;CYP4A14;PRKCB;PRKACA
    Non-alcoholic fatty liver disease (NAFLD)COX7A2L;CYCS;IRS2;TNF;COX7B2;RAC1;TNFRSF1A;IRS1;ADIPOQ
    Type I diabetes mellitusIL12B;GZMB;HLA-F;CD86;CD80;IL1B;IL1A;HLA-DPA1;INS1
    Prion diseasesIL1A;HSPA5;C6;MAPK1;BAX;NCAM1;C7;C1QB;C1QC
    Salmonella infectionIFNG1-2;TLR4BA;NOS2B;CDC42L;ROCK2;FOS;MAPK8B;ACTB;CASP1
    Chagas disease (American trypanosomiasis)PLCB1;IL6;CD3G;PIK3CD;MAPK3;IL-8;MAPK13;AKT1;MAPK8
    African trypanosomiasisAPOA1;HBA2;IL18;IL1B2;GNAQ;IL12B;PLCB2;IDO2;FAS
    Herpes simplex infectionCSNK2A2;CD74A;TLR9;HLA-DRA;PTPN11B;SRSF6A;PPP1CC;IL12BA;IFNA2
    Inflammatory bowel disease (IBD)IL1A;Il23a; Il12b;GATA3;IL12A;HLA-DOB;IL17A;HLA-DRB1;Il2;HLA-DMB
    Rheumatoid arthritisLTB;CTLA4;GM-CSF;HLA-DMB;IFNG;ATP6AP1;IL15;FLT1;ATP6V1D
    Graft-versus-host diseaseH2-AA;HLA-F;FAS;CD80;HLA-DOA;HLA-DPA1;IL1B;HLA-DMA;IL1A

    IL1B has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1B itself. We selected most functions IL1B had, and list some proteins which have the same functions with IL1B. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityFasl;IFNPHI1;TNFSF4;HMGB1A;INHBAB;Il2;BMP4;INHBC;TNFSF12
    interleukin-1 receptor bindingIL36B;TRIP6;IRAK4;TLR5;TLR9;Il1f6;IL1F10;IL1B;IL36RN
    protein domain specific bindingMRPL17;RAN;XPA;CNOT1;DRD3;NCK1;CSNK2B;ICA1;FOXA3

    IL1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1B.

    IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How does IL-1β initiate inflammasome assembly, and which experimental techniques unravel this intricate process? 07/30/2022

    Inflammasome assembly initiated by IL-1β is deciphered using techniques like co-immunoprecipitation, proximity ligation assays, and super-resolution microscopy.

    What are the specific mechanisms underlying IL-1β's priming of immune cells, and how can flow cytometry and gene expression analyses decipher these molecular pathways? 07/08/2021

    IL-1β's priming of immune cells is dissected through flow cytometry, RNA sequencing, and chromatin immunoprecipitation, revealing its epigenetic and transcriptional effects.

    How do post-translational modifications regulate IL-1β's biological activity, and how can mass spectrometry-based phosphoproteomics provide insights into these modifications? 06/06/2020

    Mass spectrometry-based phosphoproteomics deciphers IL-1β's post-translational modifications, revealing regulatory sites crucial for its activation and signaling.

    How can advanced bioinformatics tools be applied to multi-omics data to comprehensively understand the intricate roles of IL-1β in health and disease? 04/16/2020

    Bioinformatics tools integrate multi-omics data to provide a comprehensive understanding of IL-1β's roles, revealing its intricate contributions to health and disease.

    What is the significance of IL-1β's epigenetic regulation in chronic inflammatory diseases, and how can ChIP-seq and DNA methylation profiling uncover these regulatory elements? 11/01/2019

    ChIP-seq and DNA methylation profiling uncover IL-1β's epigenetic impact on target genes, shedding light on its role in shaping chronic inflammatory states.

    How does IL-1β interact with its downstream effectors to induce the production of pro-inflammatory cytokines, and how can dual-luciferase reporter assays reveal these intricate interactions? 03/31/2019

    IL-1β's interactions with downstream effectors are unveiled using dual-luciferase reporter assays, surface plasmon resonance, and co-crystallization studies.

    What are the complex feedback loops between IL-1β and other cytokines, and how can systems biology approaches like network analysis dissect these dynamic interactions? 01/24/2019

    Network analysis integrates omics data to unravel IL-1β's intricate cross-talk with other cytokines, mapping out complex regulatory loops in inflammation.

    What is the role of IL-1β in modulating the tumor microenvironment, and how can advanced imaging techniques like intravital microscopy elucidate its impact on immune cell dynamics? 08/08/2017

    IL-1β's impact on the tumor microenvironment is studied using intravital microscopy, 3D culture models, and single-cell RNA sequencing to capture dynamic cell behavior.

    What are the mechanisms underlying IL-1β's non-canonical signaling pathways, and how can CRISPR-Cas9 screening identify key mediators of these alternative pathways? 04/18/2017

    CRISPR-Cas9 screening identifies IL-1β's non-canonical signaling mediators through functional genomics, revealing alternative pathways in cellular responses.

    How does IL-1β's signaling adapt to different cellular contexts, and how can single-cell RNA sequencing uncover cell-specific responses to this cytokine? 01/03/2017

    Single-cell RNA sequencing unveils IL-1β's context-specific responses, exposing cell type-specific signaling and gene expression patterns.

    Customer Reviews (3)

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      Effective in inflammation studies. -


        High specificity. -


          Suitable for cytokine assays. -

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