il1b
Share
  • Official Full Name
  • interleukin 1 beta
  • Background
  • Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
  • Synonyms
  • Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA
Cat.#:IL1B-132HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B Protein
+Inquiry
Cat.#:IL1B-364HTag:
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human IL1B Protein
+Inquiry
Cat.#:Il1B-466HTag:HIgG1 Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1B, HIgG1 Fc-tagged
+Inquiry
Cat.#:IL1B-920CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL1B Protein (Ala115-Ser266)
+Inquiry
Cat.#:IL1B-461HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta
+Inquiry
Cat.#:Il1b-462MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 1 Beta
+Inquiry
Cat.#:Il1b-463RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin-1 beta
+Inquiry
Cat.#:IL1B-14167HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, GST-tagged
+Inquiry
Cat.#:IL1B-23HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B
+Inquiry
Cat.#:Il1B-464HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1B, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:IL1B-465HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL1B, MIgG2a Fc-tagged
+Inquiry
Cat.#:IL1B-60HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His-tagged
+Inquiry
Cat.#:IL1B-744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His tagged
+Inquiry
Cat.#:IL1b-82HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-1 beta
+Inquiry
Cat.#:IL1B-9908HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL1B
+Inquiry
Cat.#:Il1b-2830MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His & GST-tagged
+Inquiry
Cat.#:Il1b-2831MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His & T7-tagged
+Inquiry
Cat.#:Il1b-383MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b, None tagged
+Inquiry
Cat.#:Il1b-509MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il1b protein, His-tagged
+Inquiry
Cat.#:Il1b-603MTag:Met
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b
+Inquiry
Cat.#:IL1B-8135MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL1B Protein
+Inquiry
Cat.#:Il1b-8899MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il1b
+Inquiry
Cat.#:Il1b-384RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1b, His tagged
+Inquiry
Cat.#:IL1B-577RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat IL1B, His tagged
+Inquiry
Cat.#:IL1B-1167CTag:
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL1B Protein
+Inquiry
Cat.#:IL1B-2239RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL1B Protein, His-tagged
+Inquiry
Cat.#:Il1b-25CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-1 beta
+Inquiry
Cat.#:IL1B-2827DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL1B protein, His-tagged
+Inquiry
Cat.#:IL1B-656CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL1B
+Inquiry
Cat.#:IL1B-1782CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL1B protein, His-tagged
+Inquiry
Cat.#:IL1B-2834RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1B protein, His & T7-tagged
+Inquiry
Cat.#:IL1B-6093CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL1B
+Inquiry
Cat.#:IL1B-667RTag:
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1B
+Inquiry
Cat.#:IL1B-12106ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL1B
+Inquiry
Cat.#:IL1B-1024PTag:
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1B Protein
+Inquiry
Cat.#:IL1B-1030FTag:
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline IL1B Protein
+Inquiry
Cat.#:IL1B-2826CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL1B protein, His & T7-tagged
+Inquiry
Cat.#:IL1B-2828HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse IL1B protein, His-tagged
+Inquiry
Cat.#:Il1b-2829GTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Il1b protein, His & S-tagged
+Inquiry
Cat.#:IL1B-2832STag:His/T7
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep IL1B protein, His & T7-tagged
+Inquiry
Cat.#:IL1B-2833PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1B protein, His-tagged
+Inquiry
Cat.#:Il1b-390CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il1b, Met-tagged
+Inquiry
Cat.#:IL1b-56OTag:
Source (Host):YeastSpecies:Ovine
Product nameRecombinant Ovine IL-1 beta
+Inquiry
Cat.#:IL1B-027ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B (117-269aa)
+Inquiry
Cat.#:IL1B-321HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B, His-tagged
+Inquiry
Cat.#:IL1B-339HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1B
+Inquiry
Cat.#:Il1b-040ETag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1b (118-269aa), Met tagged
+Inquiry
Cat.#:IL1B-559RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus macaque Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-589CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-394MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Interleukin 1 Beta
+Inquiry
Cat.#:IL1B-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-134HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Beta, His-tagged
+Inquiry
Cat.#:Il1b-04MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-1 Beta
+Inquiry
Cat.#:Il1b-105MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 1 Beta, His-tagged
+Inquiry
Cat.#:Il1b-93RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 1 beta
+Inquiry
Cat.#:IL1B-243CTag:N/A
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-232BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-251ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 1, Beta
+Inquiry
Cat.#:IL1B-259FTag:N/A
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline Interleukin 1, Beta
+Inquiry
Cat.#:IL1β-82PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Interleukin-1 beta
+Inquiry
Cat.#:IL1B-853HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL1B cell lysate
+Inquiry
Cat.#:IL1B-4316HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL1B protein
+Inquiry
Cat.#:IL1B-83HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-1 Beta (rDNA derived) Reference standard
+Inquiry
Cat.#:Il1b-133MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-1 beta (rDNA derived) Reference standard
+Inquiry

Involved Pathway

Il1b involved in several pathways and played different roles in them. We selected most pathways Il1b participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKCBA; MAP2K2B; GRB2A; MAP2K4; GRB2; ARRB1; PPP3CCB; HRASB; ARR3B; RASGRF2B
Cytokine-cytokine receptor interaction
IFNA7; XCR1; GHRA; TNFSF13; IL1R1; IL9; CCL3L3; IFNAR1; CCL25B; TNFRSF13B
NF-kappa B signaling pathway
GM1987; TRAF3; LTA; XIAP; BCL2A1A; IL-8; NFKB2; MAP3K7; PTGS2; TRADD
Apoptosis
CAPN1B; BCAP31; FASLG; PRKAR2A; CASP3B; BCL2; BIRC3; CYCS; GZMC; PRKAR1AB
Osteoclast differentiation
LILRA2; cgr2b; SPI1; TGFBR2; AKT1; BLNK; LILRB2; TYK2; IFNAR1; PPP3R2
Toll-like receptor signaling pathway
PIK3R3A; IFNAR2; TLR2-1; MAPK12A; MAPK13; MAP2K4A; IFNAR1; MAPK8B; TLR2; IL1B
NOD-like receptor signaling pathway
TNFAIP3; RIPK2; MAPK11; BIRC2; HSP90AA1.1; NLRP3; CXCL8B.3; PYDC1; HSP90AA1.2; CASPA
Cytosolic DNA-sensing pathway
POLR3E; POLR3H; IFNA4; IFNA14; POLR3K; IFNA12; IFNA21; POLR2F; Ifna11; CCL4
Hematopoietic cell lineage
GM2002; ITGA4; CD34; IL1R1; MS4A1; CD8A; CD8B1; CD1D; IL1B; CD36
TNF signaling pathway
TRAF2; MAPK3; CREB3L3; CASP7; TRAF5; TRADD; RPS6KA5; MAP2K6; SOCS3; RIPK1
Inflammatory mediator regulation of TRP channels
PRKCE; PTGER2; HTR2C; PIK3R3; PIK3R5; CYP2C39; TRPV2; CYP2J2; PLA2G4D; MAPK12
Non-alcoholic fatty liver disease (NAFLD)
PRKAA1; RELA; PRKAG2; UQCR11; PKLR; NDUFB7; NDUFA2; NDUFV3; IL6; NDUFS5
Type I diabetes mellitus
HLA-DQA1; HLA-DPB1; CD80; FASLG; HLA-F; H2-Q10; PTPRN2; IL1B; HLA-DRB5; GZMB
Alzheimers disease
BAD; CYCS; NDUFA2; ATP2A2; NDUFA13; COX6A1; CALM1; NDUFA12; MAPK1; CDK5R1
Prion diseases
C5; ELK1; C8B; PRKACA; IL6; CASP12; PRKACG; LAMC1; NOTCH1; C9
Salmonella infection
RHOG; WASL; CXCL8B.3; RELA; KLC1; CXCL2; RAB7B; DYNC1LI2; RAC1B; PFN3
Pertussis
C4BP; TNF; C1RA; MAPK12; C2; ITGB1; GNAI2; MAPK13; GNAI3; C1R
Legionellosis
IL12A; CR1; NFKB1; TNF; NFKB2; BNIP3; NAIP1; RAB1; VCP; NAIP6
Leishmaniasis
TLR4; FOS; IFNGR2; HLA-DQA2; ITGAM; IFNGR1; C3; FCGR1; PTPN6; FCGR3A
Chagas disease (American trypanosomiasis)
CCL3L1; SMAD2; PIK3CG; PLCB3; GNAI1; GNAL; NOS2; GNA15; PLCB4; NFKB1
African trypanosomiasis
IL10; PLCB2; F2RL1; IL12A; APOL1; IFNG; PRKCG; ICAM1; TLR9; SELE
Malaria
VCAM1; HGF; MYD88; KLRC4-KLRK1; TLR2; CSF3; Ccl12; TGFB1; IL18; ICAM1
Amoebiasis
GNA15; COL4A4; PLCB4; LAMA1; PTK2; CD1D; LAMC1; GNAS; PRKACA; ACTN3
Tuberculosis
MAPK3; RHOA; RELA; TNFRSF1A; CD74; PPP3CC; IRAK1; FCGR3; CD209B; RFX5
Measles
CD3E; CD3D; CCND3; PIK3CA; IL1B; IFNA8; HSPA6; IFNA14; EIF2AK1; IFNA12; DDX58
Influenza A
CPSF4; PLG; IL8L1; NLRP3; HNRNPUL1; IL8L2; IL1B; HLA-DMA; PIK3CB; NXT1
Herpes simplex infection
HLA-DOB; EEF1D; TP53; BLA; TLR9; PVRL1; HLA-B; SRSF6A; CDK1; Ccl12
Inflammatory bowel disease (IBD)
IL17A; IFNG; HLA-DPB1; TLR2; IL4R; IL12RB2; IL21; IL17F; Il2; HLA-DRB1
Rheumatoid arthritis
ATP6V1B1; TGFB2; TNFRSF11A; CD28; HLA-DRB5; FLT1; ATP6V1G1; TEK; ATP6V1E2; MMP3
Graft-versus-host disease
HLA-DOB; HLA-DMA; CD86; HLA-F; HLA-E; HLA-DQB1; FAS; HLA-DRA; KIR2DL3; IL6

Protein Function

Il1b has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1b itself. We selected most functions Il1b had, and list some proteins which have the same functions with Il1b. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein BMP1; TNFSF12; GDF5; IL10; IFNW1; Ccl27a; SECTM1; CSF1B; IL3; AIMP1
Function interleukin-1 receptor binding
Related Protein IL37; IL1RN; TLR5; IL36A; IL1A; IL1F10; IL1RAP; Il1f6; IL36B; IRAK1
Function protein domain specific binding
Related Protein YWHAQB; TRP63; YWHAZ; TRIM11; E2F4; YWHAE; RAB6A; ICA1; HGS; VCP

Interacting Protein

Il1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1b.
IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

Il1b Related Articles

McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).