Recombinant Human Vascular Endothelial Growth Factor A

• Cat.No.: VEGFA-715H
• Product Overview: Recombinant humanVascular Endothelial Growth Factor 165, a 23 kDa protein consisting of 165amino acid residues, is produced as a homodimer.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: This gene is amember of the platelet-derived growth factor (PDGF)/vascular endothelialgrowth factor (VEGF) family and encodes a protein that is often found as adisulfide linked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects.
• Form: Lyophilized withoutadditives.
• Purity: > 90% asdetermined by SDS-PAGE and visualized by silver stain.
• Molecular Mass: 45 kDa
• Endotoxin Level: < 0.1 ng/μg ofVEGF165.
• Biological Activity: Determined by thestimulation of 3H-thymidine incorporation and cell proliferationby human umbilical vein endothelial cells. The ED50 range is 1-2ng/ml.
• Reconstitution: Centrifuge vialprior to opening. Add PBS or medium containing at least 0.1% HSA or BSA tothe vial to fully solubilize the protein to a concentration of 50 μg/ml.Please note that the addition of any carrier protein into this product mayproduce unwanted endotoxin. This depends upon the particular application employed.
• Storage: Lyophilized proteinis stable for 6 months at -20°C to -80°C. Store reconstituted protein inworking aliquots at -20°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: VEGFA
• Pathways: Bladder cancer;Cytokine-cytokine receptor interaction; Endochondral Ossification; Focaladhesion; Glypican 1 network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Heart Development; Hemostasis; HypertrophyModel; Id Signaling Pathway; Integrins in angiogenesis; Neurophilininteractions with VEGF and VEGFR; Pancreatic cancer; Pathways in cancer

Gene Information

• Gene Name: VEGFA vascular endothelialgrowth factor A [ Homo sapiens ]
• Synonyms: VEGFA;vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascularendothelial growth factor A; OTTHUMP00000016487; OTTHUMP00000016488;OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987;OTTHUMP00000224107; OTTHUMP00000224108; OTTHUMP00000224109;OTTHUMP00000224153; OTTHUMP00000224154; OTTHUMP00000224423;OTTHUMP00000224424; OTTHUMP00000224425; OTTHUMP00000224426;OTTHUMP00000224427; OTTHUMP00000224428; OTTHUMP00000224429;OTTHUMP00000224430; vascular permeability factor; Vascular endothelial growth factor A; Vascular permeability factor
• Gene ID: 7422
• mRNA Refseq: NM_001025366
• Protein Refseq: NP_001020537
• MIM: 192240
• UniProt ID: P15692
• Chromosome Location: 6p12
• Function: cell surfacebinding; chemoattractant activity; cytokine activity; extracellular matrixbinding; fibronectin binding; growth factor activity; heparin binding;platelet-derived growth factor receptor binding; protein binding; proteinheterodimerization activity; vascular endothelial growth factor receptor 1binding; vascular endothelial growth factor receptor 2 binding; vascularendothelial growth factor receptor binding