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| Cat. No.: | VEGFA-715H |
| Product Overview: | Recombinant humanVascular Endothelial Growth Factor 165, a 23 kDa protein consisting of 165amino acid residues, is produced as a homodimer. |
| Description: | This gene is amember of the platelet-derived growth factor (PDGF)/vascular endothelialgrowth factor (VEGF) family and encodes a protein that is often found as adisulfide linked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects. |
| Source: | Insect cells |
| Species: | Human |
| Form: | Lyophilized withoutadditives. |
| Purity: | > 90% asdetermined by SDS-PAGE and visualized by silver stain. |
| Molecular Mass: | 45 kDa |
| Endotoxin Level: | < 0.1 ng/μg ofVEGF165. |
| Biological Activity: | Determined by thestimulation of 3H-thymidine incorporation and cell proliferationby human umbilical vein endothelial cells. The ED50 range is 1-2ng/ml. |
| Reconstitution: | Centrifuge vialprior to opening. Add PBS or medium containing at least 0.1% HSA or BSA tothe vial to fully solubilize the protein to a concentration of 50 μg/ml.Please note that the addition of any carrier protein into this product mayproduce unwanted endotoxin. This depends upon the particular application employed. |
| Storage: | Lyophilized proteinis stable for 6 months at -20°C to -80°C. Store reconstituted protein inworking aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol: | VEGFA |
| Pathways: | Bladder cancer;Cytokine-cytokine receptor interaction; Endochondral Ossification; Focaladhesion; Glypican 1 network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Heart Development; Hemostasis; HypertrophyModel; Id Signaling Pathway; Integrins in angiogenesis; Neurophilininteractions with VEGF and VEGFR; Pancreatic cancer; Pathways in cancer |
| Gene Name: | VEGFA vascular endothelialgrowth factor A [ Homo sapiens ] |
| Synonyms: | VEGFA;vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascularendothelial growth factor A; OTTHUMP00000016487; OTTHUMP00000016488;OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987;OTTHUMP00000224107; OTTHUMP00000224108; OTTHUMP00000224109;OTTHUMP00000224153; OTTHUMP00000224154; OTTHUMP00000224423;OTTHUMP00000224424; OTTHUMP00000224425; OTTHUMP00000224426;OTTHUMP00000224427; OTTHUMP00000224428; OTTHUMP00000224429;OTTHUMP00000224430; vascular permeability factor; Vascular endothelial growth factor A; Vascular permeability factor |
| Gene ID: | 7422 |
| mRNA Refseq: | NM_001025366 |
| Protein Refseq: | NP_001020537 |
| MIM: | 192240 |
| UniProt ID: | P15692 |
| Chromosome Location: | 6p12 |
| Function: | cell surfacebinding; chemoattractant activity; cytokine activity; extracellular matrixbinding; fibronectin binding; growth factor activity; heparin binding;platelet-derived growth factor receptor binding; protein binding; proteinheterodimerization activity; vascular endothelial growth factor receptor 1binding; vascular endothelial growth factor receptor 2 binding; vascularendothelial growth factor receptor binding |
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