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Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

Cat. No. : SERPINE1-5509H
Product Overview : Recombinant HumanPlasminogen Activator Inhibitor type 1 tPA Complex. Human PAI-1 stable mutantis reacted with an excess of human sc-tPA at physiological pH. SERPINE1 wasexpressed in E. coli, which having a molecule weight of 113.0 kDa.
Description : SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine proteaseinhibitor (serpin) that functions as the principal inhibitor of tissueplasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (SERPINE1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. In addition,protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, isthe main inhibitor of the plasminogen activators.
Source : E. coli
Species : Human
Molecule Weight : 113.0 kDa
Form : Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4.
Concentration : 1.0 mg/ml
Storage : Storein working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : SERPINE1
Pathways : Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway;Senescence and Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway
PAI-1 in complexwith the SMB domain of Vitronectin PDB 1OC0. :

Gene Name : SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ]
Synonyms : SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpinE1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine(or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activatorinhibitor type 1), member 1
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121
Chromosome Location : 7q21.3-q22
Function : peptidase inhibitoractivity; protease binding; protein binding; contributes to receptor binding;serine-type endopeptidase inhibitor activity

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