Recombinant Human Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged

• Cat.No.: PAK1-5512H
• Product Overview: Recombinant humanfull length PAK1, GST-tagged.

Specification

• Cat. No.: PAK1-5512H
• Description: PAK1 is aserine/threonine kinase that is a target for restenosis, cancer, and immunosuppressiontreatment. PAK proteins are critical effectors that link RhoGTPases tocytoskeleton reorganization and nuclear signaling. PAK proteins, a family ofserine/threonine p21-activated kinases, include PAK1, PAK2, PAK3 and PAK4.These proteins serve as targets for the small GTP binding proteins Cdc42 andRac and have been implicated in a wide range of biological activities. PAK1regulates cell motility and morphology. Alternative transcripts of this genehave been found, but their full-length natures have not yet been determined.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 88.1 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PAK1
• Pathways: Adaptive ImmuneSystem; Chemokine signaling pathway; Developmental Biology; ErbB signalingpathway; Fc gamma R-mediated phagocytosis; Generation of second messengermolecules; Integrin-mediated cell adhesion; MAPK signaling pathway;Neurotrophic factor-mediated Trk receptor signaling; Osteopontin-mediatedevents; PLK1 signaling events; Regulation of Actin Cytoskeleton; Semaphorininteractions; T Cell Receptor Signaling Pathway

Gene Information

• Gene Name: PAK1 p21 protein(Cdc42/Rac)-activated kinase 1 [ Homo sapiens ]
• Synonyms: PAK1; p21 protein(Cdc42/Rac)-activated kinase 1; PAKalpha; MGC130000; MGC130001; serine/threonine-proteinkinase PAK 1; p65-PAK; p21-activated kinase 1; alpha-PAK; OTTHUMP00000228567;OTTHUMP00000228568; OTTHUMP00000228569; OTTHUMP00000228570; STE20 homolog,yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related);p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); EC 2.7.11.1; EC2.7.11
• Gene ID: 5058
• mRNA Refseq: NM_002576
• Protein Refseq: NP_002567
• MIM: 602590
• UniProt ID: Q13153
• Chromosome Location: 11q13-q14
• Function: ATP binding;collagen binding; nucleotide binding; protein binding; contributes to proteinbinding; protein kinase activity; protein serine/threonine kinase activity