PAK1
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Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 1
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Overview
Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms of serine/threonine kinases. These three isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. -
Synonyms
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) , p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); serine/threonine-protein kinase PAK 1; STE20 homolog; yeast; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); PAKalpha; MGC130000; MGC130001;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PAK1 Related Articles
- PAK1 Related Research Area
- PAK1 Related Signal Pathway
PAK1 involved in several pathways and played different roles in them. We selected most pathways PAK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | NTRK2;FLNC;RELA;CACNA2D3;PLA2G4C;MEF2CB;TP53;MINK1;FGF12 |
ErbB signaling pathway | CAMK2A;AKT1;PAK6B;EGFRA;PIK3CD;ERBB4A;PAK7;MAPK8;PIK3R3B |
Ras signaling pathway | FGFR1;FGFR4;FGF21;ABL1;RAP1A;RASGRF2;RGL2;Fasl;SHC2 |
cAMP signaling pathway | ATP1B3;GLI3;MAPK10;PIK3R1;PDE4C;GRIN2D;MAPK1;PIK3R2;ATP1B2 |
Chemokine signaling pathway | CXCL6;CCL23;CXCL5;SHC2;GM2506;LOC100033925;GNGT2;PPBP;XCL2 |
Axon guidance | AP2A1;CSF2;AP2S1;DLG4;JAK3;DLG3;PHB;NEFLB;EPHA6 |
Focal adhesion | VTNA;RAPGEF1B;Itga10&Itgb1;ITGA5;MAPK8;MYL9A;COMP;ITGB4;MYLPF |
Natural killer cell mediated cytotoxicity | TNFRSF10A;IFNA2;ICAM1;FYN;MAP2K2;HLA-C;IFNA1;IFNGR2;TNF |
T cell receptor signaling pathway | MAPK1;CD8B1;LCP2;DLG1;TEC;MAPK13;NFKBIE;PPP3CC;CD3E; CD3D |
Fc gamma R-mediated phagocytosis | FCGR1A;CFL2;PRKCA;PIK3R2;PPAP2C;CFL1;MAPK3;PLCG2;MYO10 |
Regulation of actin cytoskeleton | PDGFAB;Itga10&Itgb1;CFL2;BRK1;FGF12A;ITGB1;ACTG1;ACTN4;FGF14 |
Epithelial cell signaling in Helicobacter pylori infection | MAPK8;CXCL1;GIT1;TCIRG1;NFKB1;F11R;JAM3;MAPK9;RELA |
Proteoglycans in cancer | RAF1;PTPN11;HOXD10;PPP1R12B;IGF1R;FZD5;HRAS;AKT2;ITPR3 |
Renal cell carcinoma | PTPN11;PIK3R1;PIK3CG;TGFB1;ARAF;GRB2;PIK3CB;TGFB2;SLC2A1 |
PAK1 has several biochemical functions, for example, ATP binding, Rac GTPase binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK1 itself. We selected most functions PAK1 had, and list some proteins which have the same functions with PAK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ATP2B1A;CLK2B;CHD1L;NME3;AK5;SMC3;OASL1;KATNAL1;P2RX5 |
Rac GTPase binding | ARFIP2;PAK2;PAK2B;NOX1;DOCK7;FLNA;EPS8;RAB7A;CDKL5 |
collagen binding | PAK1;CD44;LACRT;CTSS;MMP9;NID2;CCBE1;C1QTNF1;SERPINH1 |
protein binding | REPS1;TP53;REEP6;ZNF488;YIPF2;CWC15;CIB1;MAPK11;NHP2 |
contributes_to protein binding | TAF10;MSH2;MEF2A;ACVR2A;CRY1A;CPSF3L;INHA;INTS10;TGFBR3 |
protein kinase activity | PRKAB1;EPHA4A;NEK1;PRPF4BB;NRBP1;CSNK2A2A;MAPKAPK2B;NEK5;JAK2A |
protein serine/threonine kinase activity | PRKACAA;AAK1;PRKACAB;DYRK2;ULK2;SRPK1A;ILK;CAMK2D1;TBK1 |
PAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK1.
RAC1
- Q&As
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Q&As (7)
Ask a questionPAK1 has been implicated in cancer progression due to its roles in cell survival, motility, and angiogenesis. Its overexpression has been observed in various tumors and is often associated with increased invasiveness and poor prognosis.
Given PAK1's involvement in cancer progression and other diseases, it has emerged as a potential therapeutic target. Several PAK1 inhibitors are under investigation for their potential in cancer therapy and other conditions where PAK1 signaling is dysregulated.
Once activated, PAK1 phosphorylates a variety of substrates, including kinases, cytoskeletal proteins, and transcription factors. Some of its known targets include Raf-1, MEK1, and LIM kinases.
PAK1 is a serine/threonine kinase that plays a crucial role in multiple cellular processes, including cytoskeletal reorganization, cell motility, and cell survival, primarily through its role in various signaling pathways.
PAK1 regulates cytoskeletal dynamics by phosphorylating and modulating the activity of several cytoskeletal proteins, including filamin, LIM kinases, and myosin light chain, thereby influencing cell shape, motility, and adhesion.
PAK1 is activated through binding to the GTP-bound forms of Cdc42 or Rac, small Rho GTPases. This binding induces a conformational change in PAK1, leading to its autophosphorylation and activation.
While mutations in PAK1 are not commonly associated with hereditary diseases, its overexpression or hyperactivation has been linked to various cancers, promoting cell proliferation, survival, and migration.
Customer Reviews (3)
Write a reviewWorked as expected, perfect.
Quick and efficient delivery.
High purity, excellent yield.
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