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PAK1

  • Official Full Name

    p21 protein (Cdc42/Rac)-activated kinase 1

  • Overview

    Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms of serine/threonine kinases. These three isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation.
  • Synonyms

    PAK1; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) , p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); serine/threonine-protein kinase PAK 1; STE20 homolog; yeast; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); PAKalpha; MGC130000; MGC130001;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAK1-17H Active Recombinant Human PAK1 E.coli N/A
Human PAK1-1259H Active Recombinant Human PAK1, GST-tagged E.coli GST 67-150
Human PAK1-178H Active Recombinant Human PAK1(150-end) Protein, N-Flag-tagged Sf21 Flag 150-end
Human PAK1-1070 Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged Sf9 Insect Cell GST
Human PAK1-378H Recombinant Human PAK1, GST-tagged, Active Sf9 Insect Cell GST
Human PAK1-1513H Recombinant Human PAK1, GST-tagged E.coli GST 14-65aa
Human PAK1-5512H Recombinant Human Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged Insect Cell GST
Human PAK1-821H Recombinant Human PAK1 Protein, GST-tagged E.coli GST
Human PAK1-1275HCL Recombinant Human PAK1 cell lysate N/A
Human PAK1-768H Recombinant Human PAK1 Protein, His-tagged E.coli His Glu252~Cys501
Human PAK1-5422H Recombinant Human PAK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PAK1-9380HF Active Recombinant Full Length Human PAK1 Protein, GST-tagged Insect (sf21) GST 1-545
Human PAK1-4366H Recombinant Human PAK1 protein, His-SUMO-tagged E.coli His-SUMO 1-545aa
Human PAK18058H Recombinant Human PAK1 (249-545) (K299R) Protein
Human PAK125798H Recombinant Human PAK1 (249-545) (K299R, T423E, E503D) Protein
Human PAK1-2727H Recombinant Human PAK1 Protein (Glu252-Cys501), His tagged E.coli His Glu252-Cys501
Mouse Pak1-4662M Recombinant Mouse Pak1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PAK1-4259R Recombinant Rat PAK1 Protein Mammalian Cell His
Rat PAK1-3921R-B Recombinant Rat PAK1 Protein Pre-coupled Magnetic Beads HEK293
Rat PAK1-3921R Recombinant Rat PAK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PAK1-11475Z Recombinant Zebrafish PAK1 Mammalian Cell His
Chicken PAK1-3962C Recombinant Chicken PAK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAK1 Related Articles
  • PAK1 Related Research Area
  • PAK1 Related Signal Pathway

PAK1 involved in several pathways and played different roles in them. We selected most pathways PAK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNTRK2;FLNC;RELA;CACNA2D3;PLA2G4C;MEF2CB;TP53;MINK1;FGF12
ErbB signaling pathwayCAMK2A;AKT1;PAK6B;EGFRA;PIK3CD;ERBB4A;PAK7;MAPK8;PIK3R3B
Ras signaling pathwayFGFR1;FGFR4;FGF21;ABL1;RAP1A;RASGRF2;RGL2;Fasl;SHC2
cAMP signaling pathwayATP1B3;GLI3;MAPK10;PIK3R1;PDE4C;GRIN2D;MAPK1;PIK3R2;ATP1B2
Chemokine signaling pathwayCXCL6;CCL23;CXCL5;SHC2;GM2506;LOC100033925;GNGT2;PPBP;XCL2
Axon guidanceAP2A1;CSF2;AP2S1;DLG4;JAK3;DLG3;PHB;NEFLB;EPHA6
Focal adhesionVTNA;RAPGEF1B;Itga10&Itgb1;ITGA5;MAPK8;MYL9A;COMP;ITGB4;MYLPF
Natural killer cell mediated cytotoxicityTNFRSF10A;IFNA2;ICAM1;FYN;MAP2K2;HLA-C;IFNA1;IFNGR2;TNF
T cell receptor signaling pathwayMAPK1;CD8B1;LCP2;DLG1;TEC;MAPK13;NFKBIE;PPP3CC;CD3E; CD3D
Fc gamma R-mediated phagocytosisFCGR1A;CFL2;PRKCA;PIK3R2;PPAP2C;CFL1;MAPK3;PLCG2;MYO10
Regulation of actin cytoskeletonPDGFAB;Itga10&Itgb1;CFL2;BRK1;FGF12A;ITGB1;ACTG1;ACTN4;FGF14
Epithelial cell signaling in Helicobacter pylori infectionMAPK8;CXCL1;GIT1;TCIRG1;NFKB1;F11R;JAM3;MAPK9;RELA
Proteoglycans in cancerRAF1;PTPN11;HOXD10;PPP1R12B;IGF1R;FZD5;HRAS;AKT2;ITPR3
Renal cell carcinomaPTPN11;PIK3R1;PIK3CG;TGFB1;ARAF;GRB2;PIK3CB;TGFB2;SLC2A1

PAK1 has several biochemical functions, for example, ATP binding, Rac GTPase binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK1 itself. We selected most functions PAK1 had, and list some proteins which have the same functions with PAK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP2B1A;CLK2B;CHD1L;NME3;AK5;SMC3;OASL1;KATNAL1;P2RX5
Rac GTPase bindingARFIP2;PAK2;PAK2B;NOX1;DOCK7;FLNA;EPS8;RAB7A;CDKL5
collagen bindingPAK1;CD44;LACRT;CTSS;MMP9;NID2;CCBE1;C1QTNF1;SERPINH1
protein bindingREPS1;TP53;REEP6;ZNF488;YIPF2;CWC15;CIB1;MAPK11;NHP2
contributes_to protein bindingTAF10;MSH2;MEF2A;ACVR2A;CRY1A;CPSF3L;INHA;INTS10;TGFBR3
protein kinase activityPRKAB1;EPHA4A;NEK1;PRPF4BB;NRBP1;CSNK2A2A;MAPKAPK2B;NEK5;JAK2A
protein serine/threonine kinase activityPRKACAA;AAK1;PRKACAB;DYRK2;ULK2;SRPK1A;ILK;CAMK2D1;TBK1

PAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK1.

RAC1

Butz, M; Kast, P; et al. Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. JOURNAL OF STRUCTURAL BIOLOGY 185:168-177(2014).
Gallicchio, MA; Bach, LA; et al. Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833:2922-2932(2013).
  • Q&As
  • Reviews

Q&As (7)

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What role does PAK1 play in cancer progression and metastasis? 01/16/2022

PAK1 has been implicated in cancer progression due to its roles in cell survival, motility, and angiogenesis. Its overexpression has been observed in various tumors and is often associated with increased invasiveness and poor prognosis.

Are there any therapeutic implications related to targeting PAK1 in diseases? 07/17/2021

Given PAK1's involvement in cancer progression and other diseases, it has emerged as a potential therapeutic target. Several PAK1 inhibitors are under investigation for their potential in cancer therapy and other conditions where PAK1 signaling is dysregulated.

What are the downstream targets of PAK1 in signal transduction? 11/10/2018

Once activated, PAK1 phosphorylates a variety of substrates, including kinases, cytoskeletal proteins, and transcription factors. Some of its known targets include Raf-1, MEK1, and LIM kinases.

What is the primary function of the PAK1 protein in cellular signaling? 10/23/2018

PAK1 is a serine/threonine kinase that plays a crucial role in multiple cellular processes, including cytoskeletal reorganization, cell motility, and cell survival, primarily through its role in various signaling pathways.

How does PAK1 contribute to cytoskeletal dynamics? 06/17/2018

PAK1 regulates cytoskeletal dynamics by phosphorylating and modulating the activity of several cytoskeletal proteins, including filamin, LIM kinases, and myosin light chain, thereby influencing cell shape, motility, and adhesion.

How is PAK1 activated in cells? 01/24/2018

PAK1 is activated through binding to the GTP-bound forms of Cdc42 or Rac, small Rho GTPases. This binding induces a conformational change in PAK1, leading to its autophosphorylation and activation.

Are there any known genetic mutations in the PAK1 gene associated with diseases? 01/01/2018

While mutations in PAK1 are not commonly associated with hereditary diseases, its overexpression or hyperactivation has been linked to various cancers, promoting cell proliferation, survival, and migration.

Customer Reviews (3)

Write a review
Reviews
01/07/2020

    Worked as expected, perfect.

    01/23/2019

      Quick and efficient delivery.

      01/18/2018

        High purity, excellent yield.

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