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Recombinant Human Fas Ligand (TNF superfamily, member 6)
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Cat. No. : | FASLG-5413H |
Product Overview : | Recombinant Humansoluble FASLG contains 175 amino acid residues and comprises the TNFhomologous region of Fasl. |
Description : | FASLG is a type-II transmembraneprotein that belongs to the tumor necrosis factor (TNF) family. Its bindingwith its receptor induces apoptosis. Fas ligand/receptor interactions play animportant role in the regulation of the immune system and the progression ofcancer. |
Source : | CHO cells |
Species : | Human |
Form : | Lyophilized withoutadditives. |
Molecular Weight : | 19.9 kDa |
Purity : | >98% asdetermined by SDS-PAGE analysis. |
Endotoxin Level : | <0.1 ng/ug |
Biological Activity : | Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is<5.0 ng/ml. |
Specific Activity : | >2 x 105units/mg |
Reconstitution : | Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions. |
Storage : | Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | FASLG |
Gene Name : | FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ] |
Synonyms : | FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6 |
Gene ID : | 356 |
mRNA Refseq : | NM_000639 |
Protein Refseq : | NP_000630 |
MIM : | 134638 |
UniProt ID : | P48023 |
Chromosome Location : | 1q23 |
Pathway : | Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus |
Function : | cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding |
◆ Recombinant Protein
FASLG-1394H | Recombinant Human FASLG Protein (103-281 aa), His-tagged | +Inquiry |
FASLG-3855H | Recombinant Human FASLG Protein | +Inquiry |
FASLG-5412H | Recombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged | +Inquiry |
FASLG-3857H | Recombinant Human FASLG Protein, GST-tagged | +Inquiry |
FASLG-2180P | Recombinant Pig FASLG Protein, His&SUMO-tagged | +Inquiry |
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◆ Lysates
FASLG-6324HCL | Recombinant Human FASLG 293 Cell Lysate | +Inquiry |
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