FASLG

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FASLG

Official Full Name Fas ligand (TNF superfamily, member 6)
Background The Fas receptor (FasR) is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is also known as CD95, Apo-1, and tumor necrosis factor receptor superfamily, member 6 (TNFRSf6). FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution are found in most mammals. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
Synonyms FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; soluble form; APO1L; Apoptosis antigen ligand 1; CD178 antigen; CD95; L CD95L protein; Fas L; Fas ligand; Fasl Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; Gld; TNF superfamily member 6; TNFL6_HUMAN; Fas-L
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • S
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FASLG-1394H Recombinant Human FASLG Protein (103-281 aa), His-tagged Yeast His
    Human FASLG-151H Recombinant Human FASLG Protein, His-tagged Human Cells His
    Human FASLG-1616H Recombinant Human Fas ligand (TNF superfamily, member 6) CHO N/A
    Human FASLG-234H Recombinant Human FASLG, C13&N15-labeled HEK293 N/A
    Human FASLG-2424H Recombinant Human FASLG, FLAG-tagged Human Cell Flag
    Human FASLG-245H Recombinant Human FASLG, Fc-tagged HEK293 Fc
    Human FASLG-2703H Recombinant Human FASLG, His-tagged CHO His
    Human FASLG-28165TH Recombinant Human FASLG N/A
    Human FASLG-3855H Recombinant Human FASLG Protein Wheat Germ N/A
    Human FASLG-3857H Recombinant Human FASLG Protein, GST-tagged Wheat Germ GST
    Human FASLG-46H Recombinant Human FASLG protein, His-tagged HEK293 His
    Human FASLG-5412H Recombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged CHO His
    Human FASLG-5413H Recombinant Human Fas Ligand (TNF superfamily, member 6) CHO N/A
    Human FASLG-623H Recombinant Human FASLG protein, His & GST-tagged E.coli His/GST
    Human FASLG-624H Recombinant Human FASLG protein, His & S-tagged E.coli His/S
    Human FASLG-6324HCL Recombinant Human FASLG 293 Cell Lysate HEK293 N/A
    Human FASLG-7108H Recombinant Human FASLG, His-tagged E.coli His
    Mouse Fasl-1736M Recombinant Mouse Fas Ligand (TNF Superfamily, Member 6) Mammalian cells N/A
    Mouse Faslg-372M Recombinant Mouse Faslg Protein, His-tagged Yeast His
    Rat FASLG-2274R Recombinant Rat FASLG Protein Mammalian Cell His
    Rat Faslg-373R Recombinant Rat Faslg Protein, His-tagged Yeast His
    Rat Faslg-626R Recombinant Rat Faslg protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey FASLG-514C Recombinant Cynomolgus FASLG Protein, His-tagged Mammalian Cell His
    Rhesus Macaque FASLG-1645R Recombinant Rhesus monkey FASLG Protein, His-tagged Mammalian Cell His
    Rhesus monkey FASLG-627R Recombinant Rhesus monkey FASLG protein, His & T7-tagged E.coli His/T7
    Chicken FASLG-3201C Recombinant Chicken FASLG Mammalian Cell His
    Zebrafish FASLG-3825Z Recombinant Zebrafish FASLG Mammalian Cell His

    FASLG involved in several pathways and played different roles in them. We selected most pathways FASLG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PPP3CB; CACNA1SB; MAPK8B; GNA12A; CACNA1H; MEF2C; PAK2A; MAP2K2A; RPS6KA2; IL1A
    Ras signaling pathway PLA2G6; MET; PLA2G4C; PLCE1; PLCG1; BAD; RASGRP3; GRIN2B; INS2; PAK6
    Cytokine-cytokine receptor interaction IL-15RA; VEGFC; IL22RA2; CCL25B; CCL14; CCL11; Il23a; Il12b; LTA; IL2RB; CCL13
    FoxO signaling pathway TNFSF10; TGFBR1; RBL2; GABARAPL2; PLK4; GRM1; IL7R; RAF1B; PDPK1; TGFBR1B
    PIK-Akt signaling pathway LAMC1; YWHAB; LAMB1; CCNE2; ITGB1; FGF18; ITGB6; PDGFD; INSR; LAMA5
    Apoptosis CASP3B; CAPN2A; PRKAR1A; MYD88; VIML; NFKBIAB; PPP3CCB; APAF1; IRF6; DIABLOB
    Natural killer cell mediated cytotoxicity Ifna11; PRF1; KIR2DL4; IFNAR1; SHC1; PRKCG; ULBP1; LCP2; MAP2K2; BID
    Neurotrophin signaling pathway CALM4; SORT1; RELA; MAP2K5; MAP2K2; CALM3; MAP3K3; AKT2; PIK3CA; RPS6KA5
    Non-alcoholic fatty liver disease (NAFLD) IL-8; COX7A2L; NDUFB9; SREBF1; NDUFB6; NDUFA4L2; AKT2; SDHB; IL1A; UQCRH
    Type I diabetes mellitus HLA-A; HLA-DPA1; HLA-DMB; H2-AA; INS2; HLA-DOA; HLA-G; PTPRN2; Il2; HLA-DQB1
    Chagas disease (American trypanosomiasis) TNF; PLCB4; Ccl12; SMAD3; GNAI2; CD3G; PPP2R2C; GNA15; NOS2; IL1B
    African trypanosomiasis PLCB1; PRKCA; TNF; SELE; PRKCG; IDO1; HBA2; THOP1; VCAM1; PLCB3
    Hepatitis B IFNA16; IFNA4; HSPG2; CREB3L2; APAF1; NFATC1; PIK3R5; ELK1; IFIH1; PIK3CA
    Measles IFNGR2; IFNGR1; TNFSF10; CCNE1; FASLG; AKT1; BBC3; IFNA6; RAB9B; CD209
    Influenza A VDAC1; HLA-DQA1; PIK3CG; NFKBIB; OAS1A; FASLG; STAT2; IFNGR1; IL1B; TNFRSF10A
    Herpes simplex infection IFNA2; Hc; IRF3; IFNA5; TNFRSF14; IFNPHI1; LTA; CUL1B; PKZ; MHC1UXA2
    Pathways in cancer TGFA; WNT2; WNT3; FZD10; EP300; PML; RUNX1T1; WNT16; BMP2; HGF
    Proteoglycans in cancer TFAP4; FASLG; ROCK1; TRP53; WNT5B; MAPK13; CAV1; CTTN; PPP1CA; SRC
    Autoi IFNA21; TG; HLA-DRB5; HLA-DQA2; HLA-DRB1; HLA-DMB; IFNA13; IFNA16; HLA-E; IFNA4
    ne thyroid disease TSHR; IFNA12; IFNA13; TPO; HLA-F; HLA-DPA1; HLA-DOA; TG; HLA-A; IFNA7
    Allograft rejection MICA; H2-Q10; Il2; CD40LG; HLA-F; CD80; IFNG; HLA-A; IL10; HLA-DRA
    Graft-versus-host disease HLA-F; Fasl; HLA-DRB4; HLA-DQB1; FAS; GZMB; IL1B; KIR2DL3; KIR3DL2; Il2

    FASLG has several biochemical functions, for example, cytokine activity, death receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FASLG itself. We selected most functions FASLG had, and list some proteins which have the same functions with FASLG. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity SECTM1; CD40LG; SCG2; HMGB1; CMTM2; IL1RN; TGFB2; LIF; INHBAB; GM13279
    death receptor binding Casp3; BID; FASLG; NOL3; MYD88; FADD; Fasl; TNFSF15; RIPK1; TMBIM1
    protein binding PLD3; CLOCK; DERL1; BUD13; GDF7; PITPNM3; GLS2; ZMYM4; SERTAD1; RAD51B
    receptor binding HACL1; GSTK1; PTK6; Ren1; CCL2; Fert2; ABL1; FASLG; FRK; WNT4A
    tumor necrosis factor receptor binding FADD; TNFSF9; CD70; FASLG; TNFSF13; EDA; TNFSF10L; ERAP1; TRAF2; LTB

    FASLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASLG here. Most of them are supplied by our site. Hope this information will be useful for your research of FASLG.

    PSTPIP1; FAS; FADD; CASP8; SRGAP2; FYN

    Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
    Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).

    TNF

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