Cat. No. :	MET-1272H
Product Overview :	Recombinant humanMET catalytic domain (amino acids 956-1390) with N-terminal His tag.
Description :	MET is a receptor-liketyrosine kinase whose disregulation has been linked to many types of humanmalignancies. No special measures were taken to activate this kinase.
Source :	insect cells
Species :	Human
Form :	Liquid in 20 mMTris, pH 7.5 + 100 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol
Molecular Weight :	53.7 kDa
Purity :	≥ 90% as determinedby SDS-PAGE analysis
Storage :	Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol :	MET
Crystallographicstructure of MET. PDB rendering based on 1r0p. :

Gene Name :	MET met proto-oncogene(hepatocyte growth factor receptor) [ Homo sapiens ]
Synonyms :	MET; metproto-oncogene (hepatocyte growth factor receptor); HGFR; AUTS9; RCCP2;c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; oncogeneMET; HGF/SF receptor; OTTHUMP00000024917; OTTHUMP00000069168; proto-oncogenec-Met; scatter factor receptor; tyrosine-protein kinase Met; metproto-oncogene tyrosine kinase; EC 2.7.10.1; EC 2.7.10
Gene ID :	4233
mRNA Refseq :	NM_000245
Protein Refseq :	NP_000236
MIM :	164860
UniProt ID :	P08581
Chromosome Location :	7q31
Pathway :	Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Bacterial invasion of epithelialcells; Cytokine-cytokine receptor interaction; Developmental Biology;Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; FGFsignaling pathway; Melanoma; Pathways in cancer; Renal cell carcinoma;Semaphorin interactions; Signaling events mediated by TCPTP;Syndecan-1-mediated signaling events
Function :	ATP binding;hepatocyte growth factor-activated receptor activity; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity

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