Cat. No.: | MET-1272H |
Product Overview: | Recombinant humanMET catalytic domain (amino acids 956-1390) with N-terminal His tag. |
Description: | MET is a receptor-liketyrosine kinase whose disregulation has been linked to many types of humanmalignancies. No special measures were taken to activate this kinase. |
Source: | insect cells |
Species: | Human |
Form: | Liquid in 20 mMTris, pH 7.5 + 100 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol |
Molecular Weight: | 53.7 kDa |
Purity: | ≥ 90% as determinedby SDS-PAGE analysis |
Storage: | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol: | MET |
Gene Name: | MET met proto-oncogene(hepatocyte growth factor receptor) [ Homo sapiens ] |
Synonyms: | MET; metproto-oncogene (hepatocyte growth factor receptor); HGFR; AUTS9; RCCP2;c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; oncogeneMET; HGF/SF receptor; OTTHUMP00000024917; OTTHUMP00000069168; proto-oncogenec-Met; scatter factor receptor; tyrosine-protein kinase Met; metproto-oncogene tyrosine kinase; EC 2.7.10.1; EC 2.7.10 |
Gene ID: | 4233 |
mRNA Refseq: | NM_000245 |
Protein Refseq: | NP_000236 |
MIM: | 164860 |
UniProt ID: | P08581 |
Chromosome Location: | 7q31 |
Pathway: | Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Bacterial invasion of epithelialcells; Cytokine-cytokine receptor interaction; Developmental Biology;Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; FGFsignaling pathway; Melanoma; Pathways in cancer; Renal cell carcinoma;Semaphorin interactions; Signaling events mediated by TCPTP;Syndecan-1-mediated signaling events |
Function: | ATP binding;hepatocyte growth factor-activated receptor activity; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity |
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