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| Cat. No.: | LRRTM1-5682H |
| Product Overview: | Recombinant Human LRRTM1protein was expressed in Murine myeloma cell line with a C-terminal 6-Histag. Ala35-Ile425. |
| Description: | Human LRRTM1 is a58-59 kDa type I transmembrane protein that belongs to the LRRTM family ofproteins within the leucine-rich repeat superfamily. It is synthesized as aprecursor with a 34 amino acid signal sequence, a 393 aa luminal region, a 21aa transmembrane region, and a 74 aa cytoplasmic region. The luminal portionof LRRTM1 contains three N-linked glycosylation sites and 10 LRRs flanked bycysteine-rich domains. The cytoplasmic region contains several tyrosine,serine, and threonine residues that have potential to be phosphorylated andthus to be involved in signal transduction. |
| Source: | Murine myeloma cellline, NS0-derived. |
| Form: | Lyophilized from a0.2 μm filtered solution in PBS. |
| N-terminalSequence: | Ala35 |
| Molecular Weight: | 44.4 kDa |
| Activity: | Measuredby its ability to enhance neurite outgrowth of E18 rat embryonic corticalneurons. Able to significantly enhance neurite outgrowth when immobilized at6-25 μg/mL on a nitrocellulose-coated microplate. |
| Endotoxin Level: | <1.0 EUper 1 μg of the protein by the LAL method. |
| SDS-PAGE: | 70-85kDa, reducing conditions. |
| Purity: | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution: | 100μg/mL in sterile PBS |
| Storage: | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
| Gene Name: | LRRTM1 leucine rich repeattransmembrane neuronal 1 [ Homo sapiens ] |
| Official Symbol: | LRRTM1 |
| Synonyms: | LRRTM1; leucine richrepeat transmembrane neuronal 1; FLJ32082; leucine-rich repeat transmembraneneuronal protein 1; leucine-rich repeat transmembrane neuronal 1 protein;UNQ675/PRO1309; OTTHUMP00000194829; OTTHUMP00000202801; OTTHUMP00000203404 |
| Gene ID: | 347730 |
| mRNA Refseq: | NM_178839 |
| Protein Refseq: | NP_849161 |
| MIM: | 610867 |
| UniProt ID: | Q86UE6 |
| Chromosome Location: | 2p12 |
| Function: | molecular function |
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