Recombinant Mouse Agouti Related Protein


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Recombinant Mouse Agouti Related Protein

Agrp Related Products

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Cat. No. : Agrp-546M
Product Overview : Recombinant Mouse Agrpprotein was expressed in E. coli. Ser82-Thr131.
Description : Agrp, the proteinproduct of the Agouti Related Transcript (ART), is a neuroprotein thatregulates energy metabolism and the development of obesity by antagonizing αmelanocytestimulating hormone (α-MSH) action on MC-3 and MC-4 receptors. Agrp is predominantlyexpressed in the hypothalamus and adrenal medulla. Mature mouse Agrp is a 111amino acid (aa) polypeptide; its C-terminal portion contains ten conservedcysteines that form five disulfide bonds. Within the C-terminal region, mouseAgrp shares 80% and 90% aa sequence identity with human and rat Agrp,respectively. It also shares 44% aa sequence identity with Agrp. As with Agrp,the C-terminal cysteine rich region is sufficient for biological activity.
Source : E. coli-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Ser82
Molecular Weight : 5.7 kDa
Activity : Measured by itsability to antagonize α-MSHinduced c-AMP accumulation on human MelanocortinReceptor 4 transfected BaF3 mouse proB cells. The ED50 for thiseffect is typically 1-4 μg/mL in the presence of 10 ng/mL of α-MSH.
Endotoxin Level : < 1.0EU per 1 μg of the protein by the LAL method.
Purity : > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100μg/mL in sterile PBS.
Storage : Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Agrp agouti related protein [ Musmusculus ]
Official Symbol : Agrp
Synonyms : Agrp; agouti relatedprotein; Art;Agrt; agouti-related protein; orexigenic neuropeptide
Gene ID : 11604
mRNA Refseq : NM_007427
Protein Refseq : NP_031453
UniProt ID : P56473
Chromosome Location : 8; 8 D1-D2
Pathway : Adipocytokine signalingpathway; Adipogenesis
Function : neuropeptide hormoneactivity

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