"Agrp" Related Products


Recombinant Mouse Agouti Related Protein

Cat. No.: Agrp-546M
Product Overview: Recombinant Mouse Agrpprotein was expressed in E. coli. Ser82-Thr131.
Description: Agrp, the proteinproduct of the Agouti Related Transcript (ART), is a neuroprotein thatregulates energy metabolism and the development of obesity by antagonizing αmelanocytestimulating hormone (α-MSH) action on MC-3 and MC-4 receptors. Agrp is predominantlyexpressed in the hypothalamus and adrenal medulla. Mature mouse Agrp is a 111amino acid (aa) polypeptide; its C-terminal portion contains ten conservedcysteines that form five disulfide bonds. Within the C-terminal region, mouseAgrp shares 80% and 90% aa sequence identity with human and rat Agrp,respectively. It also shares 44% aa sequence identity with Agrp. As with Agrp,the C-terminal cysteine rich region is sufficient for biological activity.
Source: E. coli-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Ser82
Molecular Weight: 5.7 kDa
Activity: Measured by itsability to antagonize α-MSHinduced c-AMP accumulation on human MelanocortinReceptor 4 transfected BaF3 mouse proB cells. The ED50 for thiseffect is typically 1-4 μg/mL in the presence of 10 ng/mL of α-MSH.
Endotoxin Level: < 1.0EU per 1 μg of the protein by the LAL method.
Purity: > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 100μg/mL in sterile PBS.
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Agrp agouti related protein [ Musmusculus ]
Official Symbol: Agrp
Synonyms: Agrp; agouti relatedprotein; Art;Agrt; agouti-related protein; orexigenic neuropeptide
Gene ID: 11604
mRNA Refseq: NM_007427
Protein Refseq: NP_031453
UniProt ID: P56473
Chromosome Location: 8; 8 D1-D2
Pathway: Adipocytokine signalingpathway; Adipogenesis
Function: neuropeptide hormoneactivity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.