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Active Recombinant Human Laminin α4

Cat.No. : LAMA4-6952H
Product Overview : Recombinant Human Lamininα4 protein, was expressed in Chinese Hamster Ovary cell line, CHOderived andpurified by SDS-PAGE
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Cat. No. : LAMA4-6952H
Description : Laminin subunitalpha-4 is a protein that in humans is encoded by the LAMA4 gene. Laminins, afamily of extracellular matrix glycoproteins, are the major noncollagenousconstituent of basement membranes. They have been implicated in a widevariety of biological processes including cell adhesion, differentiation,migration, signaling, neurite outgrowth and metastasis. Laminins are composedof 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, andB2, respectively) and they form a cruciform structure consisting of 3 short arms,each formed by a different chain, and a long arm composed of all 3 chains.Each laminin chain is a multidomain protein encoded by a distinct gene.Several isoforms of each chain have been described
Source : CHO Cells
MolecularMass : 111 kDa
Purity : >90%, by SDSPAGE underreducing conditions and visualized by silver stain.
Activity : Measured by theability of the immobilized protein to support the adhesion of HT1080 humanfibrosarcoma cells. The ED50 for this effect is typically 0.7-2.8 μg/mL.Optimal dilutions should be determined by each laboratory for eachapplication
EndotoxinLevel : <1.0 EU per 1 μgof the protein by the LAL method.
N-terminalSequenceAnalysis : Gln826 predicted,sequencing might be blocked, no result obtained
Formulation : Lyophilized from a0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 200μg/mL in PBS
Storage : Use a manual defrostfreezer and avoid repeated freeze thaw Cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name : LAMA4 laminin, alpha 4 [ Homosapiens ]
Official Symbol : LAMA4
Synonyms : LAMA4;laminin, alpha 4; LAMA3; LAMA4*-1; DKFZp686D23145; Laminin-14 subunit alpha;Laminin-8 subunit alpha; Laminin-9 subunit alpha
Gene ID : 3910
mRNA Refseq : NM_001105206
Protein Refseq : NP_001098676
MIM : 600133
UniProt ID : Q16363
Chromosome Location : 6q21
Pathway : extracellularmatrix structural constituent; receptor binding
Function : Africantrypanosomiasis; Amoebiasis; ECM-receptor interaction; FOXM1 transcriptionfactor networ; Focal adhesion; Pathways in cancer; Small cell lung cancer;Toxoplasmosis

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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