Recombinant Human PPIB protein, His-tagged
Cat.No. : | PPIB-652H |
Product Overview : | Recombinant Human PPIB (Asp34-Ala212) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
Protein Length : | Asp34-Ala212 |
Description : | Peptidyl-prolyl cis-trans isomerase B (PPIB or PPIase B) is also known as Cyclophilin B (CYPB), Rotamase B, S-cyclophilin (SCYLP), is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum, which belongs to the cyclophilin-type PPIase family and PPIase B subfamily. PPIB / CYPB contains one PPIase cyclophilin-type domain. PPIases accelerate the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Predicted N Terminal : | Asp34 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 20.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Publications : |
Further Characterization of the Target of a Potential Aptamer Biomarker for Pancreatic Cancer: Cyclophilin B and Its Posttranslational Modifications. (2013)
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Gene Name | PPIB |
Official Symbol | PPIB |
Synonyms | PPIB; peptidylprolyl isomerase B (cyclophilin B); peptidyl-prolyl cis-trans isomerase B; CYPB; OI9; PPIase B; rotamase B; S-cyclophilin; cyclophilin-like protein; SCYLP; CYP-S1; MGC2224; MGC14109 |
Gene ID | 5479 |
mRNA Refseq | NM_000942 |
Protein Refseq | NP_000933 |
MIM | 123841 |
UniProt ID | P23284 |
◆ Recombinant Proteins | ||
PPIB-652H | Recombinant Human PPIB protein, His-tagged | +Inquiry |
PPIB-2673H | Recombinant Human PPIB Protein, MYC/DDK-tagged | +Inquiry |
PPIB-001H | Recombinant Human peptidylprolyl isomerase B Protein, His tagged | +Inquiry |
PPIB-26338TH | Recombinant Full Length Human PPIB, GST-tagged | +Inquiry |
PPIB-3544R | Recombinant Rhesus monkey PPIB Protein, His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
PPIB-2460HCL | Recombinant Human PPIB cell lysate | +Inquiry |
Further Characterization of the Target of a Potential Aptamer Biomarker for Pancreatic Cancer: Cyclophilin B and Its Posttranslational Modifications
Journal: Nucleic Acid Therapeutics PubMed ID: 24152208 Data: 2013/12/1
Authors: Partha Ray, Bruce A. Sullenger, Rebekah R. White
Article Snippet:The C-terminal endoplasmic reticulum (ER) retention motif (Ile 213–Glu 216) was deleted, and the secreted protein was purified from the conditioned media.The C-terminal endoplasmic reticulum (ER) retention motif (Ile 213–Glu 216) was deleted, and the secreted protein was purified from the conditioned media.. The proteins (samples 1 and 2) were purchased from Creative BioMart (PPIB-652H) and Sino Biological Inc. (11004-H08H) (sample 3).. Human CypB (Leu 26–Glu 216) expressed in the bacterial Escherichia coli system (sample 5) was purchased from Prospect (ENZ-313).Human CypB (Leu 26–Glu 216) expressed in the bacterial Escherichia coli system (sample 5) was purchased from Prospect (ENZ-313).
Not For Human Consumption!
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