Recombinant Human LATS2, Unactive, GST-tagged

• Cat.No.: LATS2-1541H
• Product Overview: Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 480-1088 aa
• Description: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis. LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~98 kDa
• Purity: >80%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.2μg/μl

Gene Information

• Gene Name: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: LATS2
• Synonyms: LATS2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 2; serine/threonine-protein kinase LATS2; warts-like kinase; serine/threonine kinase KPM; large tumor suppressor homolog 2; serine/threonine-protein kinase kpm; kinase phosphorylated during mitosis protein; KPM; FLJ13161
• Gene ID: 26524
• mRNA Refseq: NM_014572
• Protein Refseq: NP_055387
• MIM: 604861
• UniProt ID: Q9NRM7
• Chromosome Location: 13q11-q12
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Hippo, organism-specific biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity