Recombinant Human FKBP1A, GST-tagged
Cat.No. : | FKBP1A-7000H |
Product Overview : | Recombinant full length human FKBP1A was expressed in E. coli cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | FKBP1A is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and Rapamycin. FKBP1A interacts with various type I receptors, including the TGF-beta type I receptor and competitive binding assays show that the type I receptor may be a natural ligand for FKBP1A. FKBP1A-deficient mice have normal skeletal muscle but show severe dilated cardiomyopathy and ventricular septal defects that mimick a human congenital heart disorder. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~38.3 kDa |
Protein length : | Full length |
Purity : | >95% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2μg/μl |
Gene Name : | FKBP1A FK506 binding protein 1A, 12kDa [ Homo sapiens ] |
Official Symbol : | FKBP1A |
Synonyms : | FKBP1A; FK506 binding protein 1A, 12kDa; FK506 binding protein 1A (12kD) , FKBP1; peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP 12; FKBP12; FKBP12C; PKC12; PPIASE; rotamase; 12 kDa FKBP; calstabin-1; FKBP12-Exip3; PPIase FKBP1A; immunophilin FKBP12; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; 12 kDa FK506-binding protein; protein kinase C inhibitor 2; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; FKBP1; PKCI2; FKBP-12; FKBP-1A; |
Gene ID : | 2280 |
mRNA Refseq : | NM_000801 |
Protein Refseq : | NP_000792 |
MIM : | 186945 |
UniProt ID : | P62942 |
Chromosome Location : | 20p13 |
Pathway : | ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem; |
Function : | FK506 binding; FK506 binding; SMAD binding; activin binding; isomerase activity; macrolide binding; peptidyl-prolyl cis-trans isomerase activity; peptidyl-prolyl cis-trans isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; contributes_to ryanodine-sensitive calcium-release channel activity; signal transducer activity; transforming growth factor beta receptor binding; contributes_to transforming growth factor beta-activated receptor activity; type I transforming growth factor beta receptor binding; |
Products Types
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FKBP1A-2009R | Recombinant Rat FKBP1A Protein, His (Fc)-Avi-tagged | +Inquiry |
FKBP1A-4186H | Recombinant Human FKBP1A Protein, GST-tagged | +Inquiry |
Fkbp1a-3023M | Recombinant Mouse Fkbp1a Protein, Myc/DDK-tagged | +Inquiry |
FKBP1A-057H | Recombinant Human FKBP1A Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
FKBP1A-6211HCL | Recombinant Human FKBP1A 293 Cell Lysate | +Inquiry |
FKBP1A-6210HCL | Recombinant Human FKBP1A 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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