"Pyruvate kinase" Related Products

Pyruvate kinase

Cat. No.: PKLR-1544
Description: Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP.
Source: Microorganism
Predicted MolecularMass: 68kDa
Isoelectic point: 5.2
Michaelis constant: 1.1mM (ADP); 2.2mM(PEP)
Optimum pH: 7.5
Optimum temperature: 80°C
pH Stability: 5.0~10.0 (37°C, 20hr)
Thermal Stability: < 60°C (pH8.5, 20min)
Inhibitors: Ag+, Hg2+
Specific Activity: ≥ 300U/mg protein
Unit definition: One unit will convert one micromole of phosphoenolpyruvate to pyruvate per min at pH 7.2 at 30°C.
Storage: -20°C
PreparationInstructions: The enzyme is reconstituted in 50mM Tris-HCl buffer, pH 8.5 for activity assay.
IntroductionThe protein is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA).
KeywordsPyruvate kinase; EC:; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; OPA interacting protein 3; Opa interactivity protein; PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase isozyme R/L; Pyruvate kinase liver and RBC; Pyruvate kinase muscle isozyme; R type/L type pyruvate kinase; RPK; THBP 1; Thyroid hormone binding protein cytosolic

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