Cat.No. :	PFDN5-3608H
Product Overview :	Recombinant Human PFDN5(1-154aa) fused with His tag at N-terminal was expressed in E. coli.
Description :	PFDN5 belongs to the prefoldin alpha subunit family. Prefoldin (PFDN), a ubiquitously expressed heterohexameric co-chaperone, is necessary for proper folding of nascent proteins, in particular, tubulin and actin. PFDN5 is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. This protein may also repress the transcriptional activity of the proto-oncogene c-Myc.
Source :	E. coli
Species :	Human
Tag :	His
Form :	Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol
Molecular Mass :	19.5kDa (174aa), confirmed by MALDI-TOF
AA Sequence :	MGSSHHHHHH SSGLVPRGSHYVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKAMAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK ELLVPLTSSM
Purity :	>90% by SDS - PAGE
Storage :	Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration :	1 mg/ml (determined by Bradford assay)
Publication :	Prefoldin 5 and anti-prefoldin 5 antibodies as biomarkers for uveitis in ankylosing spondylitis

Gene Name :	PFDN5 prefoldin subunit 5 [ Homo sapiens ]
Official Symbol :	PFDN5
Synonyms :	PFDN5; prefoldin subunit 5; prefoldin 5; MM 1; PFD5; myc modulator-1; c-myc binding protein; MM1; MM-1; MGC5329; MGC71907;
Gene ID :	5204
mRNA Refseq :	NM_002624
Protein Refseq :	NP_002615
MIM :	604899
UniProt ID :	Q99471
Chromosome Location :	12q13.13
Pathway :	Chaperonin-mediated protein folding, organism-specific biosystem; Cooperation of Prefoldin and TriC/CCTin actin and tubulin folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Prefoldin mediated transfer of substrateto CCT/TriC, organism-specific biosystem; Protein folding, organism-specific biosystem;
Function :	protein binding; transcription corepressor activity; unfolded protein binding;

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