Recombinant Mouse Carbonic Anhydrase 2, His-tagged
Cat.No. : | Car2-1191M |
Product Overview : | A DNA sequence encoding the mouse Car2 ( AAH55291.1 ) ( Met 1 ?C Lys 260 ) was expressed, with a C-terminal polyhistidine tag |
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Cat. No. : | Car2-1191M |
Description : | Carbonic anhydrases ( Cas ) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion, they are therefore classified as metalloenzymes. Several forms of carbonic anhydrase occur in nature. |
Source : | Mouse |
Host : | E.coli |
Form : | Lyophilized from sterile 50 mM Tris, 150mM NaCl , pH 7.5 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : | > 96 % as determined by SDS-PAGE |
Endotoxin : | μ1.0 EU per μg protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 μ |
Predicted N terminal : | Ser 2 |
Molecular Mass : | The recombinant mouse Car2 comprises 270 amino acids and has a calculated molecular mass of 30.4 kDa. The recombinant protein migrates as an approximately 30-33 kDa band in SDS-PAGE under reducing conditions. |
Storage : | Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Pathways : | Bile secretion; Collecting duct acid secretion; Gastric acid secretion; Nitrogen metabolism; Pancreatic secretion |
Gene Name : | Car2 carbonic anhydrase 2 [ Mus musculus ] |
Official Symbol : | Car2 |
Synonyms : | Car2; Ca2; CAII; Car-2; Ltw-5; Lvtw-5; AI131712; 3 A1; 3 10.5 Cm; carbonic anhydrase 2; CA II; CA-II; carbonic anhydrase II; carbonate dehydratase II |
Gene ID : | 12349 |
mRNA Refseq : | NM_009801 |
Protein Refseq : | NP_033931 |
UniProt ID : | P00920 |
Chromosome Location : | 3 A1; 3 10.5 cM |
Function : | carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
CA2-425R | Recombinant Rhesus Macaque CA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA2-716R | Recombinant Rat CA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA2-479H | Recombinant Human CA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA2-1158M | Recombinant Mouse CA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA2-0238H | Recombinant Human CA2 Protein, GST-Tagged | +Inquiry |
◆ Native Protein | ||
CA2-31M | Native Mouse Carbonic Anhydrase II (CA2) Protein | +Inquiry |
CA2-33R | Native Rat Carbonic Anhydrase II (CA2) Protein | +Inquiry |
CA2-35R | Native Rhesus monkey Carbonic Anhydrase II (CA2) Protein | +Inquiry |
◆ Lysates | ||
CA2-7915HCL | Recombinant Human CA2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCA2 deficiency is a rare autosomal recessive disorder with metabolic acidosis and osteopetrosis.
Acetazolamide is a known inhibitor, used clinically for glaucoma and altitude sickness.
Some mutations can lead to CA2 deficiency, affecting acid-base balance and leading to metabolic acidosis.
CA2 is one of the most efficient and fastest enzymes, displaying higher activity than many other isoforms.
CA2 accelerates the reversible conversion of CO2 and water to bicarbonate and protons, aiding in pH regulation.
CA2 plays a crucial role in CO2 transport and acid-base balance in various tissues.
CA2 is ubiquitously expressed but is particularly abundant in red blood cells and certain epithelial tissues.
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