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Recombinant Human Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase), His-tagged

Cat. No.: KDR-317H
Product Overview: Recombinant human KDR, a 764 amino acids protein with 6 His tag at C-terminus, and has a calculated MW of 86.2 kDa. DTT-reduced protein migrates as 100-110 kDa protein due to glycosylation.
Description: Kinase insert domain receptor (KDR) is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1).VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding.
Source: Recombinant human KDR (rh KDR) Met1-Glu764 (Accession AAI31823) was expressed in human 293 cells (HEK293).
Species: Human
Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as lyophilized powder, Normally 2-7% Mannitol and Trehalose before lyophilization are added as protectants. It is recommended to reconstitute the lyophilized rh KDR in sterile dH2O.
Purity: >90% as determined by SDS-PAGE of 2 μg reduced rh KDR. All lots are greater than 90% pure.
Endotoxin: Less than 1.0 EU per 1 μg of the rh KDR by the LAL method.
Storage: Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.
Gene Name: KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Official Symbol: KDR
Synonyms: KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; EC 2.7.10.1; fetal liver kinase-1; soluble VEGFR2; tyrosine kinase growth factor receptor; fetal liver kinase 1; OTTHUMP00000158928
Gene ID: 3791
mRNA Refseq: NM_002253
Protein Refseq: NP_002244
MIM: 191306
UniProt ID: P35968
Chromosome Location: 4q11-q12
Pathway: Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; VEGF signaling pathway; Signaling by VEGF
Function: ATP binding; growth factor binding; nucleotide binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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