Active Recombinant Human KDR Protein, His&Avi tagged

• Cat.No.: KDR-79H
• Product Overview: VEGFR2 dimer protein contains a VEGFR2 extracellular domain (UniProt# P35968) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 20-764 aa
• Description: Human vascular endothelial growth factor receptor 2 (VEGFR2) belongs to the Type IV receptor tyrosine kinase (RTK) family. VEGFR2 is a key receptor in the VEGF (Vascular Endothelial Growth Factor) signaling pathway, involved in angiogenesis, the formation of new blood vessels. VEGFR2 is also known as kinase insert domain receptor (KDR), cluster of differentiation 309 (CD309), and fetal liver kinase 1 (Flk1). VEGFR2, a Type I transmembrane protein, contains an extracellular domain with 7 immunoglobulin-like (Ig-like) domains, a single transmembrane domain, and an intracellular domain. VEGFR2 is mainly expressed on vascular endothelial cells and can bind VEGF-A and VEGF-D. VEGF binding by VEGFR2 causes it to homodimerize which is essential for it to stimulate cellular responses such as vasculogenesis and angiogenesis. In pathological conditions, ligand-independent dimerization of VEGFR2 can contribute to abnormal angiogenesis. Abnormal angiogenesis is associated with a variety of diseases such as tumor neovascularization, diabetic retinopathy, rheumatoid arthritis, and age-related macular degeneration. Abnormal angiogenesis is a major contributing factor in the growth and spread of a variety of cancers and inhibition of VEGFR2 activity offers a potential and promising approach to cancer therapy.
• Molecular Mass: 187 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for VEGFR2-specific antibody and vascular endothelial growth factor A (VEGF-A) ligand protein binding assays. Suggested Applications: SPR & BLI for VEGFR2-specific antibody and VEGF-A protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [Homo sapiens (human)]
• Official Symbol 2: KDR
• Synonyms 2: KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor
• Gene ID 2: 3791
• mRNA Refseq 2: NM_002253
• Protein Refseq 2: NP_002244
• MIM 2: 191306
• UniProt ID 2: P35968