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| Cat. No.: | CSNK1G2-1008H |
| Product Overview: | Full length recombinant human CSNK1G2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | CSNK1G2 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CSNK1G2 is a ubiquitously expressed cytoplasmic kinase that can interact and phosphorylate the metastatic tumor antigen 1 short form (MTA1s) co-localizing it in the cytoplasm. Phosphorylated MTA1s then sequesters the estrogen receptor-alpha in the cytoplasm of breast cancer cells. CSNK1G2 hyperphosphorylates the ceramide transfer protein CERT leading to a decrease in de novo sphingomyelin synthesis. The reduction in synthesis of sphingomyelin is reversed by the expression of CERT mutants that are not hyperphosphorylated. |
| Applications: | Kinase Assay; Western Blot |
| Molecular Weight: | 73 kDa |
| Expression System: | Sf9 insect cells using baculovirus |
| Species: | Human |
| Form: | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Specific Activity: | 30 nmol/min/mg |
| Purity: | > 80 % |
| Concentration: | 0.1 ug/ul |
| Sequences: | Full length |
| Storage: | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways: | FoxO family signaling; Hedgehog signaling events mediated by Gli proteins; Hedgehog signaling pathway; Metabolism of lipids and lipoproteins; Sphingolipid metabolism; p53 pathway |
| Gene Name: | CSNK1G2 casein kinase 1, gamma 2 [ Homo sapiens ] |
| Official Symbol: | CSNK1G2 |
| Synonyms: | CSNK1G2; casein kinase 1, gamma 2; CK1g2; CKI-gamma 2; casein kinase 1 isoform gamma-2; casein kinase I isoform gamma-2; EC 2.7.11.1 |
| Gene ID: | 1455 |
| mRNA Refseq: | NM_001319 |
| Protein Refseq: | NP_001310 |
| MIM: | 602214 |
| UniProt ID: | P78368 |
| Chromosome Location: | 19p13.3 |
| Function: | ATP binding; glycoprotein binding; magnesium ion binding; nucleotide binding; peptide binding; phosphoprotein binding; protein serine/threonine kinase activity; transferase activity |
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