Native Human Neutrophil Elastase

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Native Human Neutrophil Elastase

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Cat.No. : ELANE-8104H
Product Overview : Human Neutrophil Elastase was purified from Human Neutrophil.
Description : Human Neutrophils, also known as neutrophilic polymorphonuclear leukocytes, are the major class of white blood cell in human peripheral blood. Human Neutrophil(s), have a multilobed nucleus and neutrophilic granules. Neutrophil(s) are phagocytes and have an important role in engulfing and killing extracellular pathogens.Neutrophil elastase (NE) is a key enzyme for tissue injury caused by activated neutrophils, such as occurs in Acute Lung injury.The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains.
Source : Human Neutrophil
Species : Human
Form : 50 mM sodium acetate, pH 5.5, 0.6 M sodium chloride
Purity : >90% by SDS-PAGE
Stability : 1 year
Storage : 2-8 °C
Concentration : Typically >1 mg/mL
Gene Name : ELANE elastase, neutrophil expressed [ Homo sapiens ]
Official Symbol : ELANE
Synonyms : ELANE; elastase, neutrophil expressed; ELA2, elastase 2, neutrophil; neutrophil elastase; HLE; HNE; leukocyte elastase; medullasin; NE; elastase-2; PMN elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow se
Gene ID : 1991
mRNA Refseq : NM_001972
Protein Refseq : NP_001963
MIM : 130130
UniProt ID : P08246
Chromosome Location : 19p13.3
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem;
Function : bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protease binding; protein binding; serine-type endopeptidase activity;

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