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Recombinant Human ABL2, His-tagged

Cat.No. : ABL2-9250H
Product Overview : Recombinant Human ABL2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : 822-1167a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens ]
Official Symbol : ABL2
Synonyms : ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-related gene protein; ABLL;
Gene ID : 27
mRNA Refseq : NM_001136000
Protein Refseq : NP_001129472
MIM : 164690
UniProt ID : P42684
Chromosome Location : 1q25.2
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem; Signaling by Robo receptor, organism-specific biosystem; Viral myocarditis, organism-specific biosystem;
Function : ATP binding; actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activit

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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Which substances are the ligands of ABL2? 05/19/2022

Magnesium, Manganese,Nucleotide, etc.

Where is ABL2 localized? 02/04/2022

ABL2 localization in cytoplasm and cytoskeleton.

Can ABL2 phosphorylate DOK1? 09/18/2021

ABL2 involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.

Is there any post-translational modification of ABL2? 01/28/2020

ABL2 has polyubiquitination and glycosylation modifications, etc.

What are the functions of ABL2? 10/22/2019

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis.

What is the relationship between abl1 and abl2? 04/15/2018

abl1 is the important paralog of abl2. abl2 plays an abl1-overlapping role in key processes linked to cell growth and survival.

What are the diseases associated with abl2? 12/03/2016

Diseases associated with ABL2 include Leukemia and B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1.

Is this gene expressed in cancer cells? 06/12/2016

This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia.

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03/16/2022

    The after-sales service is very timely.

    09/22/2020

      Custom products take time, but the quality is really good!

      04/16/2019

        It is the second time to buy your product, very good.

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