Recombinant Human ABL2, His-tagged
Cat.No. : | ABL2-9250H |
Product Overview : | Recombinant Human ABL2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 822-1167a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens ] |
Official Symbol : | ABL2 |
Synonyms : | ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-related gene protein; ABLL; |
Gene ID : | 27 |
mRNA Refseq : | NM_001136000 |
Protein Refseq : | NP_001129472 |
MIM : | 164690 |
UniProt ID : | P42684 |
Chromosome Location : | 1q25.2 |
Pathway : | Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem; Signaling by Robo receptor, organism-specific biosystem; Viral myocarditis, organism-specific biosystem; |
Function : | ATP binding; actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activit |
Products Types
◆ Recombinant Protein | ||
Abl2-502M | Recombinant Mouse Abl2 Protein, MYC/DDK-tagged | +Inquiry |
ARG-3620M | Recombinant Mouse ARG, His-tagged | +Inquiry |
Abl2-233M | Recombinant Mouse Abl2, His-tagged, Active | +Inquiry |
ABL2-106H | Recombinant Human ABL2 Protein, GST-Tagged | +Inquiry |
ABL2-233H | Active Recombinant Human ABL2, His-tagged | +Inquiry |
◆ Lysates | ||
ABL2-9126HCL | Recombinant Human ABL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionMagnesium, Manganese,Nucleotide, etc.
ABL2 localization in cytoplasm and cytoskeleton.
ABL2 involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.
ABL2 has polyubiquitination and glycosylation modifications, etc.
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis.
abl1 is the important paralog of abl2. abl2 plays an abl1-overlapping role in key processes linked to cell growth and survival.
Diseases associated with ABL2 include Leukemia and B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1.
This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia.
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