| Cat. No. : | PF4-52H |
| Product Overview : | Human PF |
| Description : | Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. |
| Source : | Human Platelets. |
| Amino Acid Sequence : | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. |
| Physical Appearance : | Sterile Filtered white lyophilized powder. |
| Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Formulation : | The protein was lyophilized in PBS buffer. |
| Solubility : | It is recommended to reconstitute the lyophilized CXCL4 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Activity Control : | Binding of HIT-antibodies. |
| Stability : | Human CXCL4 although stable at 25℃ 1 week, should be stored desiccated below -18℃. Please prevent freeze-thaw cycles. |
| Gene Name : | PF4 platelet factor 4 [ Homo sapiens ] |
| Synonyms : | PF4; platelet factor 4; CXCL4; SCYB4; MGC138298; Iroplact; Oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| Gene ID : | 5196 |
| mRNA Refseq : | NM_002619 |
| Protein Refseq : | NP_002610 |
| MIM : | 173460 |
| UniProt ID : | P02776 |
| Chromosome Location : | 4q12-q21 |
| Pathway : | Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Hemostasis; Signaling by GPCR |
| Function : | chemokine activity; heparin binding |
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