Cat. No. : |
PF4-52H |
Product Overview : |
Human PF-4 a7.8 kDa protein consisting of 70 amino acid residues. |
Description : |
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. |
Source : |
Human Platelets. |
Amino Acid Sequence : |
The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. |
Physical Appearance : |
Sterile Filtered white lyophilized powder. |
Purity : |
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : |
The protein was lyophilized in PBS buffer. |
Solubility : |
It is recommended to reconstitute the lyophilized CXCL4 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Activity Control : |
Binding of HIT-antibodies. |
Stability : |
Human CXCL4 although stable at 25℃ 1 week, should be stored desiccated below -18℃. Please prevent freeze-thaw cycles. |