Recombinant human Activin AB, Active, His-tagged
Cat.No. : | INHBA&INHBB-1544H |
Product Overview : | Recombinant Activin AB is a disulphide linked heterodimer of subunits βA / βB . βA Single chain, containing 116 aa (13.7 kDa) and βB single chain, 123 amino residues (14kDa). Recombinant human Activin AB contains a His-tag at the N-terminal end. |
- Specification
- Gene Information
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Description : | Activins are homodimers or heterodimers of the various β subunit isoforms, belonging to the TGFβ family. Mature Activin AB has two chains of 116 and 123 amino acids residues (βA-βB). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Inhibins /Activins are proteins that are formed by the dimerization of two subunits, i. e. an α with either βA –inhibin A- or βB - inhibin B. The subunits βA and βB can also form homodimers or heterodimers calleds activins: Activin A (βAβA), Activin B (βBβB) and Activin AB (βAβB). The activin gene family comprises the additional, but poorly characterized members activin βC, βD, and βE.As with other members of the super-family, Activins interact with two types of cell surface trans-membrane receptors (Types I and II) which have intrinsic serine/threonine kinase activities in their cytoplasmic domains, Activin type 1 receptors, ACVR1, ACVR1B, ACVR1C and Activin type 2 receptors, ACVR2A, ACVR2B.The development of assays distinguishing between different forms of activins and inhibins, along with knock-in and knock-out models, have provided evidence that the betaA- and betaB-subunits have independent and separate roles physiologically. Additionally, evaluation of ligand-receptor interactions indicates significant differences in receptor affinity between activin isoforms, as well as between inhibin isoforms. |
Source : | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal–derived components or impurities. Animal Free product. |
Species : | Human |
Tag : | His |
Form : | Recombinant human Activin is lyophilized from a Tris HCl 0.05M buffer at pH 7.4. |
Molecular Mass : | 13.7 kDa, 14kDa |
AA Sequence : | βA:GLECDGKVNICCKKQFFVSFKDIGW NDWIIAPSGYHANYCEGECPSHIAG TSGSSLSFHSTVINHYRMRGHSPFA NLKSCCVPTKLRPMSMLYYDDGQNI IKKDIQNMIVEECGCSβB:GLECDGRTNLCCRQQFFIDFRLIGW NDWIIAPTGYYGNYCEGSCPAYLAG VPGSASSFHTAVVNQYRMRGLNPGT VNSCCIPTKLSTMSMLYFDDEYNIV KRDVPNMIVEECGCA |
Endotoxin : | < 0.04 EU/µg protein (LAL method) |
Purity : | >97% by SDS-PAGE gel |
Storage : | This lyophilized preparation is stable at 2-8º C for short term, long storage it should be kept at -20ºC. Reconstituted protein should be stored in working aliquots at –20°C. Repeated freezing and thawing is not recommended. |
Reconstitution : | Centrifuge vial before opening. Lyophilized protein should be reconstituted in water to a concentration of 50 ng/μl. Optimal concentration should be determined for specific application and cell lines. |
Gene Name : | INHBA inhibin, beta A [ Homo sapiens ] |
Official Symbol : | INHBA |
Synonyms : | INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP; |
Gene ID : | 3624 |
mRNA Refseq : | NM_002192 |
Protein Refseq : | NP_002183 |
MIM : | 147290 |
UniProt ID : | P08476 |
Chromosome Location : | 7p15-p13 |
Pathway : | ALK1 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem; |
Function : | cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; protein binding; protein heterodimerization activity; type II activin receptor binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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