Native Human ApoC-III

• Cat.No.: ApoC-III-3559H

Specification

• Description: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
• Source: Human plasma
• Species: Human
• Form: Supplied as a liquid in 10mM NH4HCO3, pH 7.4.
• Molecular Mass: 875 kDa
• Purity: >95% pure by SDS PAGE
• Notes: Small volumes of ApoC-III native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: APOC3 apolipoprotein C-III [ Homo sapiens ]
• Official Symbol: APOC3
• Synonyms: APOC3; apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; HALP2; APOCIII; MGC150353
• Gene ID: 345
• mRNA Refseq: NM_000040
• Protein Refseq: NP_000031
• MIM: 107720
• UniProt ID: P02656
• Chromosome Location: 11q23-qter
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem
• Function: cholesterol binding; enzyme regulator activity; high-density lipoprotein particle receptor binding; lipase inhibitor activity; phospholipid binding