Native Human ApoC-III

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Native Human ApoC-III

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Cat.No. : ApoC-III-3559H
Description : Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
Source : Human plasma
Species : Human
Form : Supplied as a liquid in 10mM NH4HCO3, pH 7.4.
Molecular Mass : 875 kDa
Purity : >95% pure by SDS PAGE
Notes : Small volumes of ApoC-III native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : APOC3 apolipoprotein C-III [ Homo sapiens ]
Official Symbol : APOC3
Synonyms : APOC3; apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; HALP2; APOCIII; MGC150353;
Gene ID : 345
mRNA Refseq : NM_000040
Protein Refseq : NP_000031
MIM : 107720
UniProt ID : P02656
Chromosome Location : 11q23-qter
Pathway : Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem;
Function : cholesterol binding; enzyme regulator activity; high-density lipoprotein particle receptor binding; lipase inhibitor activity; phospholipid binding;

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