| Cat.No.: | TAF6L-1734HCL |
| Description: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. |
| Species: | Human |
| Size: | 100 ul |
| Storage Buffer: | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
| Applications: | Western Blot; |
| Gene Name: | TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa [ Homo sapiens ] |
| Official Symbol: | TAF6L |
| Synonyms: | TAF6L; TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa; TAF6 like RNA polymerase II, p300/CBP associated factor (PCAF) associated factor, 65 kD; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; PAF65A; PAF65-alpha; PCAF-associated factor 65 alpha; PCAF-associated factor 65-alpha; p300/CBP-associated factor (PCAF)-associated factor 65; MGC4288; FLJ11136; |
| Gene ID: | 10629 |
| mRNA Refseq: | NM_006473 |
| Protein Refseq: | NP_006464 |
| MIM: | 602946 |
| UniProt ID: | Q9Y6J9 |
| Chromosome Location: | 11q12.3 |
| Pathway: | Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; |
| Function: | DNA binding; contributes_to histone acetyltransferase activity; protein binding; transcription coactivator activity; |
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