Recombinant Human CPM, His-tagged CPM-175H

Recombinant Human CPM, His-tagged


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Recombinant Human CPM, His-tagged

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Cat.No. : CPM-175H
Product Overview : Recombinant Human CPM /Carboxypeptidase M Protein (rh CPM /Carboxypeptidase M) Leu 18 - His 422 (Accession # AAH22276) was produced in human 293 cells (HEK293).
Description : Carboxypeptidase M (CPM) belongs to the peptidase M14 family. CPM specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins, and the activity is inhibited by O-phenanthroline and MGTA and activated by cobalt. The amino acid sequence of CPM indicated that the C-terminal hydrophobic region might be a signal for membrane attachment via a glycosylphosphatidylinositol (GPI) anchor. CPM is involved in peptide metabolism on both the cell surface and in extracellular fluids. CPM functions not only as a protease but also as a binding partner in cell-surface protein-protein interactions.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in 50 mM MES, pH 6.5 with 100 mM NaCl. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity : Measured by its ability to release Larginine from BenzoylAlaArg, with detection of the arginine amino group by ophthaldialdehyde.The specific activity is >40,000 pmoles/min/μg.
Molecular Mass : rh CPM /Carboxypeptidase M is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 47.1 kDa. The predicted N-terminus is Leu 18. DTT-reduced Protein migrates as 49 kDa in SDS-PAGE due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the rh CPM /Carboxypeptidase M by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution : See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name : CPM carboxypeptidase M [ Homo sapiens ]
Official Symbol : CPM
Synonyms : CPM; carboxypeptidase M; renal carboxypeptidase; urinary carboxypeptidase B;
Gene ID : 1368
mRNA Refseq : NM_001874
Protein Refseq : NP_001865
MIM : 114860
UniProt ID : P14384
Chromosome Location : 12q15
Function : carboxypeptidase activity; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

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