- C. perfringens(1)
- Cynomolgus Monkey(1)
- Human(12)
- Mouse(6)
- Rhesus Macaque(1)
- Zebrafish(1)
Recombinant Human CPE, His-tagged
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| Cat.No. : | CPE-210H |
| Product Overview : | Recombinant Human CPE MS Standard Protein, C13 and N15-labeled (CPE, Heavy Labeled) Glu 26 - Ser 453 (Accession # NP_001864.1) was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain >99% incorporation efficien |
| Description : | Carboxypeptidase E (CPE) is also known as Carboxypeptidase H or enkephalin convertase. Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E appears to have several functions. The active form of carboxypeptidase E was shown to be in secretory vesicles, where it acts as an exopeptidase to activate neuropeptides, It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide. Products of carboxypeptidase E include insulin, enkephalin, and most other neuroendocrine peptides.It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting signal for regulated secretory proteins in the trans-Golgi network of the pituitary and in secretory granules; regulated secretory proteins are mostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe, display endocrine disorders like obesity and infertility. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
| Molecular Mass : | CPE, Heavy Labeled is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 49 kDa. The predicted N-terminus is Glu 26. DTT-reduced Protein migrates as 53 kDa in SDS-PAGE .CPE, Heavy Labeled is labeled with [U- 13C6, 15N4]-L-Arginine |
| Endotoxin : | Less than 1.0 EU per μg of the CPE, Heavy Labeled by the LAL method. |
| Purity : | >95% as determined by SDS-PAGE. |
| Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC). |
| Reconstitution : | See Certificate of Analysis for reconstitution instructions and specific concentrations. |
| Gene Name : | CPE carboxypeptidase E [ Homo sapiens ] |
| Official Symbol : | CPE |
| Synonyms : | CPE; carboxypeptidase E; carboxypeptidase H; cobalt stimulated chromaffin granule carboxypeptidase; enkephalin convertase; insulin granule associated carboxypeptidase; CPH; prohormone-processing carboxypeptidase; insulin granule-associated carboxypeptidase; cobalt-stimulated chromaffin granule carboxypeptidase; |
| Gene ID : | 1363 |
| mRNA Refseq : | NM_001873 |
| Protein Refseq : | NP_001864 |
| MIM : | 114855 |
| UniProt ID : | P16870 |
| Chromosome Location : | 4q32.3 |
| Pathway : | Arf6 trafficking events, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem; Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem; |
| Function : | carboxypeptidase activity; cell adhesion molecule binding; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; neurexin family protein binding; peptidase activity; zinc ion binding; |
◆ Recombinant Protein
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| CPE-1780H | Recombinant Human CPE Protein, GST-tagged | +Inquiry |
| CPE-275H | Recombinant Human CPE, Fc tagged | +Inquiry |
| Cpe-225M | Recombinant Mouse Cpe, C13&N15-labeled | +Inquiry |
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◆ Native Protein
| cpe-001C | Native C. perfringens Enterotoxin | +Inquiry |
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◆ Lysates
| CPE-2656HCL | Recombinant Human CPE cell lysate | +Inquiry |
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