"PIK3R1" Related Products


Recombinant Human PIK3R1, His-tagged

Cat.No.: PIK3R1-1079H
Product Overview: Recombinant full-length mouse p110alpha and human p85alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.?
Source: Sf9 insect cells
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 2mM DTT, 25% glycerol.
Molecular Mass: ~111 kDa (p110α), ~86 kDa (p85α)
Protein length: Full Length
Purity: >90%
Applications: Kinase Assay; Western Blot
Stability: 1 yr at -70oC from date of shipment.
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens (human) ]
Official Symbol: PIK3R1
Synonyms: PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA; phosphatidylinositol 3-kinase regulatory subunit alpha; OTTHUMP00000161918; OTTHUMP00000161919; OTTHUMP00000161920; OTTHUMP00000226152; OTTHUMP00000226159; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Gene ID: 5295
mRNA Refseq: NM_181523
Protein Refseq: NP_852664
MIM: 171833
UniProt ID: P27986
Chromosome Location: 5q13.1
Pathway: AMPK signaling; Acute myeloid leukemia; B Cell Receptor Signaling Pathway
Function: ErbB-3 class receptor binding; insulin receptor binding; insulin-like growth factor receptor binding

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