Recombinant Human SMURF2, GST-tagged SMURF2-138H

Cat.No.:	SMURF2-138H
Product Overview:	Recombinant human SMURF2 (amino acid residues 1-748), with N-terminal GST, was expressed in E.coli.
Description:	The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s), conjugating enzymes (E2s) and protein ligases (E3s). Smad-Specific E3 Ubiquitin Protein Ligase 1 (SMURF2) is a member of the E3 protein ligase family and cloning of the human gene was first described by Kavsak et al. (2000). SMURF2 is a HECT domain ubiquitin E3 ligase that has been shown to regulate cell polarity, senescence and tumor suppression (Blank et al., 2012).
Source:	E. coli
Species:	Human
Tag:	GST
Form:	50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
Molecular Mass:	~114kDa
Storage:	12 months at -70°C. Avoid multiple freeze/thaw cycles.
Concentration:	0.5mg/ml

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Gene Name:	SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Homo sapiens ]
Official Symbol:	SMURF2
Synonyms:	SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; E3 ubiquitin ligase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; MGC138150; DKFZp686F0270;
Gene ID:	64750
mRNA Refseq:	NM_022739
Protein Refseq:	NP_073576
MIM:	605532
UniProt ID:	Q9HAU4
Chromosome Location:	17q22-q23
Pathway:	Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Endocytosis, organism-specific biosystem;
Function:	SMAD binding; acid-amino acid ligase activity; identical protein binding; ligase activity; protein binding; ubiquitin-protein ligase activity;