Recombinant Human SMURF2, GST-tagged
Cat.No. : | SMURF2-138H |
Product Overview : | Recombinant human SMURF2 (amino acid residues 1-748), with N-terminal GST, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s), conjugating enzymes (E2s) and protein ligases (E3s). Smad-Specific E3 Ubiquitin Protein Ligase 1 (SMURF2) is a member of the E3 protein ligase family and cloning of the human gene was first described by Kavsak et al. (2000). SMURF2 is a HECT domain ubiquitin E3 ligase that has been shown to regulate cell polarity, senescence and tumor suppression (Blank et al., 2012). |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol |
Molecular Mass : | ~114kDa |
Storage : | 12 months at -70°C. Avoid multiple freeze/thaw cycles. |
Concentration : | 0.5mg/ml |
Gene Name : | SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Homo sapiens ] |
Official Symbol : | SMURF2 |
Synonyms : | SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; E3 ubiquitin ligase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; MGC138150; DKFZp686F0270; |
Gene ID : | 64750 |
mRNA Refseq : | NM_022739 |
Protein Refseq : | NP_073576 |
MIM : | 605532 |
UniProt ID : | Q9HAU4 |
Chromosome Location : | 17q22-q23 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | SMAD binding; acid-amino acid ligase activity; identical protein binding; ligase activity; protein binding; ubiquitin-protein ligase activity; |
Products Types
◆ Recombinant Protein | ||
SMURF2-8505M | Recombinant Mouse SMURF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMURF2-1714H | Recombinant Human SMURF2 Protein (1-748 aa), His-tagged | +Inquiry |
SMURF2-2050H | Recombinant Human SMURF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Smurf2-5985M | Recombinant Mouse Smurf2 Protein, Myc/DDK-tagged | +Inquiry |
SMURF2-0441H | Recombinant Human SMURF2 Protein (S2-E748), Tag Free | +Inquiry |
◆ Lysates | ||
SMURF2-1646HCL | Recombinant Human SMURF2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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