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Recombinant Human Glycine N-methyltransferase, His tagged

Cat. No. : GNMT -119H
Product Overview : Recombinant human GNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques,34.9kDa (315aa).
Description : Glycine N-methyltransferase, also known as GNMT, catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. This protein affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and participates in the detoxification pathway in liver cells. Also it is reported that GNMT expression is diminished in human hepatocellular carcinoma (HCC).
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Purity : > 95% by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : GNMT glycine N-methyltransferase [ Homo sapiens ]
Synonyms : glycine N-methyltransferase; glycine N-methyltransferase; EC 2.1.1.20; OTTHUMP00000016412; GNMT
Gene ID : 27232
mRNA Refseq : NM_018960
Protein Refseq : NP_061833
MIM : 606628
UniProt ID : Q14749
Chromosome Location : 6p12
Pathway : Glycine, serine and threonine metabolism
Function : folic acid binding ; glycine N-methyltransferase activity; glycine binding; methyltransferase activity; transferase activity

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