"PDK1" Related Products

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Recombinant Human Pyruvate dehydrogenase kinase, isozyme 1, His-tagged

Cat. No.: PDK1-123H
Product Overview: Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques,48.6 kDa (429 aa).
Description: PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) thatis a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSSDSGSSPA SERGVPGQVD FYARFSPSPL SMKQFLDFGS VNACEKTSFM FLRQELPVRL ANIMKEISLL PDNLLRTPSV QLVQSWYIQS LQELLDFKDK SAEDAKAIYD FTDTVIRIRN RHNDVIPTMA QGVIEYKESF GVDPVTSQNV QYFLDRFYMS RISIRMLLNQ HSLLFGGKGK GSPSHRKHIG SINPNCNVLE VIKDGYENAR RLCDLYYINS PELELEELNA KSPGQPIQVV YVPSHLYHMV FELFKNAMRA TMEHHANRGV YPPIQVHVTL GNEDLTVKMS DRGGGVPLRK IDRLFNYMYS TAPRPRVETS RAVPLAGFGY GLPISRLYAQ YFQGDLKLYS LEGYGTDAVI YIKALSTDSI ERLPVYNKAA WKHYNTNHEA DDWCVPSREP KDMTTFRSA
Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.0) containing 100 mM NaCl, 0.5 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 1 mM MgCl2, 40% glycerol
Purity: > 95% by SDS - PAGE
Concentration: 0.5 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PDK1 pyruvate dehydrogenase kinase, isozyme 1 [ Homo sapiens ]
Synonyms: EC 2.7.11.2; PDPK1; Pyruvate dehydrogenase kinase isoform 1; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; pyruvate dehydrogenase kinase 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1; PDK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
Gene ID: 5163
mRNA Refseq: NM_002610
Protein Refseq: NP_002601
MIM: 602524
UniProt ID: Q15118
Chromosome Location: 2q31.1
Pathway: Fc epsilon RI signaling pathway; T cell receptor signaling pathway; Integration of energy metabolism
Function: ATP binding; nucleotide binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity; two-component sensor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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