Recombinant Human Pyruvate dehydrogenase kinase, isozyme 1, His-tagged
Cat.No. : | PDK1-123H |
Product Overview : | Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques,48.6 kDa (429 aa). |
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Cat. No. : | PDK1-123H |
Description : | PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) thatis a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MSSDSGSSPA SERGVPGQVD FYARFSPSPL SMKQFLDFGS VNACEKTSFM FLRQELPVRL ANIMKEISLL PDNLLRTPSV QLVQSWYIQS LQELLDFKDK SAEDAKAIYD FTDTVIRIRN RHNDVIPTMA QGVIEYKESF GVDPVTSQNV QYFLDRFYMS RISIRMLLNQ HSLLFGGKGK GSPSHRKHIG SINPNCNVLE VIKDGYENAR RLCDLYYINS PELELEELNA KSPGQPIQVV YVPSHLYHMV FELFKNAMRA TMEHHANRGV YPPIQVHVTL GNEDLTVKMS DRGGGVPLRK IDRLFNYMYS TAPRPRVETS RAVPLAGFGY GLPISRLYAQ YFQGDLKLYS LEGYGTDAVI YIKALSTDSI ERLPVYNKAA WKHYNTNHEA DDWCVPSREP KDMTTFRSA |
Formulation : | Liquid. In 20 mM Tris-HCl buffer (pH 7.0) containing 100 mM NaCl, 0.5 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 1 mM MgCl2, 40% glycerol |
Purity : | > 95% by SDS - PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | PDK1 pyruvate dehydrogenase kinase, isozyme 1 [ Homo sapiens ] |
Synonyms : | EC 2.7.11.2; PDPK1; Pyruvate dehydrogenase kinase isoform 1; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; pyruvate dehydrogenase kinase 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1; PDK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial |
Gene ID : | 5163 |
mRNA Refseq : | NM_002610 |
Protein Refseq : | NP_002601 |
MIM : | 602524 |
UniProt ID : | Q15118 |
Chromosome Location : | 2q31.1 |
Pathway : | Fc epsilon RI signaling pathway; T cell receptor signaling pathway; Integration of energy metabolism |
Function : | ATP binding; nucleotide binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity; two-component sensor activity |
Products Types
◆ Recombinant Protein | ||
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PDK1-1638H | Recombinant Human PDK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PDK1-824H | Recombinant Human PDK1 Protein, MYC/DDK-tagged | +Inquiry |
PDK1-124H | Active Recombinant Human PDK1 Protein, GST-tagged | +Inquiry |
Pdk1-1932R | Recombinant Rat Pdk1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PDK1-603HCL | Recombinant Human PDK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionMay play a role in the occurrence of obesity, and the current research conclusions still need to be further verified.
PDK1 is thought to be associated with the occurrence and progression of cardiovascular disease, and may affect the health of the cardiovascular system by regulating the glucose metabolism of cardiomyocytes and the activity of phosphatase. However, further research and validation are needed.
Participates in a variety of signaling pathways, such as Akt and PKC, and affects the transmission and regulation of various signaling pathways by regulating the kinase activities of related receptors and enzymes.
PDK1 has abnormal expression in a variety of tumors, such as breast cancer, pancreatic cancer, colorectal cancer, etc., and is one of the important markers of tumor occurrence and prognosis.
The plays an important role in regulating cell metabolism and plays an important role in energy metabolism by regulating the phosphorylation state of various enzymes.
It has been identified as a potential therapeutic target for new diabetes, possibly by improving insulin signaling and glycogen synthesis, but further exploration is needed.
Customer Reviews (3)
Write a reviewPDK1 production process is strictly controlled and the quality of the product is guaranteed.
Reproducibility of PDK1 is simply unrivaled, with identical results in every experiment or application, demonstrating its high stability and reliability.
The catalytic activity of PDK1 is excellent, which can simplify complex chemical reactions and improve yields, and its scientific research value is self-evident.
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