Active Recombinant Human INHBA protein

• Cat.No.: INHBA-267H
• Product Overview: Recombinant Human INHBA was expressed in Insect cells.

Specification

• Description: Activin A is a TGF beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF beta antagonist, Follistatin.
• Source: Insect cells
• Species: Human
• Form: Lyophilized from 10 mM Citric Acid pH 3.0. Reconstitute in water to a concentration of 0.5 mg/ml. Do not vortex.
• Bio-activity: The ED50 as determined by its ability to inhibit the proliferation of Mouse MPC-11 cells is 2 ng/ml, corresponding to a specific activity of 5 x 10^5 units/mg.
• Molecular Mass: 26 kDa
• AA Sequence: GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS.
• Endotoxin: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Purity: >95% pure by SDS PAGE and HPLC
• Notes: Small volumes of Activin A recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at 4 centigrade until reconstitution. Following reconstitution aliquot and freeze at -20 centigrade for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: INHBA inhibin, beta A [ Homo sapiens ]
• Official Symbol: INHBA
• Synonyms: INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP
• Gene ID: 3624
• mRNA Refseq: NM_002192
• Protein Refseq: NP_002183
• MIM: 147290
• UniProt ID: P08476
• Chromosome Location: 7p15-p13
• Pathway: ALK1 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem
• Function: cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; protein binding; protein heterodimerization activity; type II activin receptor binding