Recombinant Human MLH1 protein, MYC/DDK-tagged
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| Cat.No. : | MLH1-234H |
| Product Overview : | Recombinant Human MLH1 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
| Description : | This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | MYC/DDK |
| Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : | 84.4 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Gene Name : | MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ] |
| Official Symbol : | MLH1 |
| Synonyms : | MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172; |
| Gene ID : | 4292 |
| mRNA Refseq : | NM_000249 |
| Protein Refseq : | NP_000240 |
| MIM : | 120436 |
| UniProt ID : | P40692 |
| Chromosome Location : | 3p22.3 |
| Pathway : | BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem; |
| Function : | ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding; |
◆ Recombinant Protein
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| MLH1-10928Z | Recombinant Zebrafish MLH1 | +Inquiry |
| MLH1-9877M | Recombinant Mouse MLH1 Protein | +Inquiry |
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◆ Lysates
| MLH1-4295HCL | Recombinant Human MLH1 293 Cell Lysate | +Inquiry |
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