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Recombinant Human MLH1 protein, MYC/DDK-tagged

Cat.No. : MLH1-234H
Product Overview : Recombinant Human MLH1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 84.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ]
Official Symbol : MLH1
Synonyms : MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172;
Gene ID : 4292
mRNA Refseq : NM_000249
Protein Refseq : NP_000240
MIM : 120436
UniProt ID : P40692
Chromosome Location : 3p22.3
Pathway : BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem;
Function : ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of germline mutations in MLH1 on Lynch syndrome and associated cancer risks? 05/11/2022

Germline mutations in MLH1 are linked to Lynch syndrome, increasing the risk of various cancers.

What role does MLH1 play in the prevention of colorectal and other hereditary cancers? 03/25/2022

MLH1 helps prevent the development of colorectal and other hereditary cancers by maintaining DNA integrity.

How do alterations in MLH1 expression or function affect chemotherapy efficacy in cancer treatment? 12/18/2021

Changes in MLH1 function can influence the effectiveness of certain chemotherapies in treating cancer.

How does MLH1 influence the cellular response to DNA damage and the maintenance of replication fidelity? 08/14/2021

MLH1 plays a role in the cellular response to DNA damage, maintaining replication accuracy.

How does MLH1 deficiency lead to microsatellite instability in cancer cells? 04/08/2021

MLH1 deficiency results in microsatellite instability, a hallmark of certain types of cancer.

How does MLH1 (MutL Homolog 1) contribute to DNA mismatch repair and genomic stability? 07/20/2019

MLH1 is essential for DNA mismatch repair, ensuring genomic stability by correcting replication errors.

What are the mechanisms by which MLH1 modulates apoptosis in response to DNA damage? 03/31/2018

MLH1 modulates apoptosis in cells with DNA damage, preventing the proliferation of damaged cells.

Customer Reviews (3)

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Reviews
11/23/2022

    Timely protein expression optimization, greatly boosts our research.

    04/22/2022

      Accurate protein structural analysis, a cornerstone of our investigations.

      10/01/2020

        Precise antibody validation, enhances our immunoprecipitation accuracy.

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