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Recombinant Human Pyruvate Kinase, Muscle, His-tagged

Cat. No.: PKM2-65H
Product Overview: Recombinant Human PKM2 is produced inE.Coliis a single, non-glycosylated, polypeptide chain having a molecular mass of 62400 Dalton with an amino-terminal hexahistidine tag. The PKM2 is purified by standard chromatographic techniques.
Description: Pyruvate kinase is a key enzyme in the glycolytic pathway. The M2 isoenzyme of pyruvate kinase is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. The marker is useful for measuring disease activity, sensitivity to chemotherapy and recurrence.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered clear solution (0.9 mg/ml).
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: PKM2-His is supplied in 1x PBS and 50% glycerol.
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Gene Name: PKM2 pyruvate kinase, muscle [ Homo sapiens ]
Synonyms: PKM2; pyruvate kinase, muscle; PK3; PKM; TCB; OIP3; CTHBP; THBP1; MGC3932;Pyruvate kinase isozymes M1/M2;EC2.7.1.40; Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; Cytosolic thyroid hormone-bin ding protein; OPA-interacting protein 3; PK, muscle type; pyruvate kinase, muscle; thyroid hormone-binding protein, cytosolic
Gene ID: 5315
mRNA Refseq: NM_002654
Protein Refseq: NP_002645
UniProt ID: P14618
MIM: 179050
Pathway: Biosynthesis of alkaloids derived from histidine and purine; Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic; Biosynthesis of alkaloids derived from shikimate pathway;Biosynthesis of alkaloids derived from terpenoid and polyketide; Biosynthesis of phenylpropanoids; Biosynthesis of plant hormones; Biosynthesis of terpenoids and steroids; Carbon fixation in photosynthetic organisms; Glycolysis / Gluconeogenesis; Metabolic pathways; Purine metabolism; Pyruvate metabolism; Type II diabetes mellitus; Diabetes pathways; Integration of energy metabolism; Metabolism of carbohydrates
Function: ATP binding; magnesium ion binding; nucleotide binding;potassium ion binding; protein binding; pyruvate kinase activity; transferase activity

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