Recombinant Human ATX1 Antioxidant Protein 1 Homolog (Yeast)


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Recombinant Human ATX1 Antioxidant Protein 1 Homolog (Yeast)

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Cat. No. : ATOX1-452H
Product Overview : Recombinant Human full length HAH1 (Copper transport protein ATOX1, Metal transport protein ATX1) cloned from human cDNA with a C-terminal purification tag was expressed inE.coli. The protein consists of the human HAH1 (residues 1-68, swissprot O00244). MW = 7.8 kDa.
Description : Copper transport protein ATOX1 is a protein that in humans is encoded by the ATOX1 gene. This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. In melanocytic cells ATOX1 gene expression may be regulated by MITF.
Source : Escherichia Coli.
Purity : > 95% by SDS-PAGE. The protein was observed as a single band migrating at amolecular weight of (<10 kDa).
Supplied As : 1 mg/ml in 50mM KH2PO4/K2HPO2, pH8.0, 2mM DTT (dithiothreitol). The concentration is calculated from the absorbance at 280nm (e280= 2680 M-1 cm-1).
Characteristics : Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 1mM. In case of precipitation, the precipitate can be partially redissolved using buffer solution with high conc. of DTT (20mM or more).
Storage : -20ºC. The protein is stable at 4ºC for at least 2 weeks and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles.
PDB rendering based on 1fe0. :

Gene Name : ATOX1 ATX1 antioxidant protein 1 homolog (yeast) [ Homo sapiens ]
Synonyms : ATOX1; ATX1 antioxidant protein 1 homolog (yeast); ATX1; HAH1; MGC138453; MGC138455; antioxidant protein 1; metal transport protein; copper transport protein; ATX1 (antioxidant protein 1, yeast) homolog 1; Copper transport protein ATOX1; Metal transport protein ATX1
Gene ID : 475
mRNA Refseq : NM_004045
Protein Refseq : NP_004036
MIM : 2270
UniProt ID : O00244
Chromosome Location : 5q32
Function : copper chaperone activity; copper-dependent protein binding; metal ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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