Recombinant Human Interleukin 8

• Cat.No.: IL8-130H
• Product Overview: Recombinant Human interleukin 8 encoding the human IL-8 protein sequence (containing the signal peptide sequence, and the mature IL-8 sequence) and was expressed in modifiedhuman 293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: IL-8 is a member of the chemokine family. Chemokines are small secreted molecules containing 4 conserved cysteine residues and 2 disulfide linkages. IL-8 is a member of the CXC family of chemokines and is also known as CXCL8. IL-8 is predominantly produced by monocytes, T cells, NK cells and neutrophils and its expression is induced by IL-1 and TNF, as well as bacterial and viral products.
• Amino Acid Sequence: SAKELRCQCIKTYSKP FH PKFIK ELRV IESGPHCANTE IIVKLSDGRELC LDP KEN WVQR VVEKFLKRAENS.
• Molecular Mass: IL-8 migrates as a band at approximately 6-8 kDa in SDS-PAGE. This compares with unmodified IL-8 that has a predicted molecular mass of 8.4 kDa.
• PI: IL-8 has a predicted pI of 9.02.
• Purity: >95%, as determined by SDS-PAGE and visualized by silver stain.
• Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
• Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
• Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Gene Information

• Gene Name: IL8 interleukin 8 [ Homo sapiens ]
• Synonyms: IL8; interleukin 8; CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; T cell chemotactic factor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; emoctakin; granulocyte chemotactic protein 1; lymphocyte-derived neutrophil-activating factor; monocyte-derived neutrophil chemotactic factor; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; K60; T-cell chemotactic factor; b-ENAP; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; Neutrophil-activating protein 1
• Gene ID: 3576
• mRNA Refseq: NM_000584
• Protein Refseq: NP_000575
• MIM: 146930
• UniProt ID: P10145
• Chromosome Location: 4q13-q21
• Pathway: Cytokine-cytokine receptor interaction; Pathways in cancer; Toll-like receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; RIG-I-like receptor signaling pathway; Signaling by GPCR
• Function: interleukin-4 receptor activity; cytokine activity; chemokine activity; protein binding