Expand| Cat. No. : | IL8-130H |
| Product Overview : | Recombinant Human interleukin 8 encoding the human IL-8 protein sequence (containing the signal peptide sequence, and the mature IL-8 sequence) and was expressed in modifiedhuman 293 cells. |
| Description : | IL-8 is a member of the chemokine family. Chemokines are small secreted molecules containing 4 conserved cysteine residues and 2 disulfide linkages. IL-8 is a member of the CXC family of chemokines and is also known as CXCL8. IL-8 is predominantly produced by monocytes, T cells, NK cells and neutrophils and its expression is induced by IL-1 and TNF, as well as bacterial and viral products. |
| Source : | Human 293 cells. |
| Amino Acid Sequence : | SAKELRCQCIKTYSKP FH PKFIK ELRV IESGPHCANTE IIVKLSDGRELC LDP KEN WVQR VVEKFLKRAENS. |
| Molecular Mass : | IL-8 migrates as a band at approximately 6-8 kDa in SDS-PAGE. This compares with unmodified IL-8 that has a predicted molecular mass of 8.4 kDa. |
| PI : | IL-8 has a predicted pI of 9.02. |
| Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
| Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
| Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
| Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
| Gene Name : | IL8 interleukin 8 [ Homo sapiens ] |
| Synonyms : | IL8; interleukin 8; CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; T cell chemotactic factor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; emoctakin; granulocyte chemotactic protein 1; lymphocyte-derived neutrophil-activating factor; monocyte-derived neutrophil chemotactic factor; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; K60; T-cell chemotactic factor; b-ENAP; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; Neutrophil-activating protein 1 |
| Gene ID : | 3576 |
| mRNA Refseq : | NM_000584 |
| Protein Refseq : | NP_000575 |
| MIM : | 146930 |
| UniProt ID : | P10145 |
| Chromosome Location : | 4q13-q21 |
| Pathway : | Cytokine-cytokine receptor interaction; Pathways in cancer; Toll-like receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; RIG-I-like receptor signaling pathway; Signaling by GPCR |
| Function : | interleukin-4 receptor activity; cytokine activity; chemokine activity; protein binding |
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