Expand
| Cat. No.: | LTA-260H |
| Product Overview: | Recombinant HumanLymphotoxin Alpha is a protein produced ininsect cellscontaining 172 amino acid residues and has an approximate molecular weight of 19.3 kDa based on SDS-PAGE gel and Mass Spectrometry due to glycosylation. |
| Description: | Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokineproduced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. |
| Source: | Insect cells. |
| Purity: | > 95% by SDS-PAGE and HPLC analysis. |
| Endotoxin Level: | < 0.1 ng per μg of TNF-beta. |
| Stabilizer: | None. |
| Formulation: | Lyophilized. |
| Biologically Activity: | The ED50was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg. |
| Reconstitution: | The human TNF-beta should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
| Stability: | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human TNF-beta should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles. |
| Gene Name: | LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ] |
| Synonyms: | LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factorbeta; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; OTTHUMP00000029184; OTTHUMP00000037612; OTTHUMP00000037613 |
| Gene ID: | 4049 |
| mRNA Refseq: | NM_000595 |
| Protein Refseq: | NP_000586 |
| MIM: | 153440 |
| UniProt ID: | P01374 |
| Chromosome Location: | 6p21.3 |
| Pathway: | Antigen processing and presentation; Cytokine-cytokine receptor interaction; Type I diabetes mellitus |
| Function: | cytokine activity; tumor necrosis factor receptor binding |
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Download Datasheet
See All LTA Products
Download Datasheet