Expand| Cat. No. : | LTA-260H |
| Product Overview : | Recombinant HumanLymphotoxin Alpha is a protein produced ininsect cellscontaining 172 amino acid residues and has an approximate molecular weight of 19.3 kDa based on SDS-PAGE gel and Mass Spectrometry due to glycosylation. |
| Description : | Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokineproduced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. |
| Source : | Insect cells. |
| Purity : | > 95% by SDS-PAGE and HPLC analysis. |
| Endotoxin Level : | < 0.1 ng per μg of TNF-beta. |
| Stabilizer : | None. |
| Formulation : | Lyophilized. |
| Biologically Activity : | The ED50was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg. |
| Reconstitution : | The human TNF-beta should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
| Stability : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human TNF-beta should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles. |
| Gene Name : | LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ] |
| Synonyms : | LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factorbeta; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; OTTHUMP00000029184; OTTHUMP00000037612; OTTHUMP00000037613 |
| Gene ID : | 4049 |
| mRNA Refseq : | NM_000595 |
| Protein Refseq : | NP_000586 |
| MIM : | 153440 |
| UniProt ID : | P01374 |
| Chromosome Location : | 6p21.3 |
| Pathway : | Antigen processing and presentation; Cytokine-cytokine receptor interaction; Type I diabetes mellitus |
| Function : | cytokine activity; tumor necrosis factor receptor binding |
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