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Official Full Name lymphotoxin alpha (TNF superfamily, member 1)
Background The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin''''s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
Synonyms LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha
    • Species :
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • Biotin
    • GST
    • His
    • His/Avi
    • Flag
    • StrepII
    • T7
    • HQ
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LTA-051H Recombinant Human LTA protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi
    Human DMABT-H19263 Mouse Anti-LTA Monoclonal Antibody Mouse N/A
    Human DMABT-H19264 Mouse Anti-LTA Monoclonal Antibody Mouse Biotin
    Human LTA-1223H Recombinant Human LTA Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human LTA-1253H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1), HQ-tagged Hordeum Vulgare HQ
    Human LTA-165H Recombinant Human Lymphotoxin Alpha (TNF Superfamily, Member 1) HEK293 N/A
    Human LTA-221H Recombinant Human LTA, StrepII-tagged Human Cell Strep II
    Human LTA-260H Recombinant Human Lymphotoxin Alpha Insect Cell N/A
    Human LTA-31074TH Recombinant Human LTA, His-tagged E.coli His
    Human LTA-310H Recombinant Human LTA protein E.coli N/A
    Human LTA-311H Recombinant Human Lymphotoxin Alpha, His-tagged E.coli His
    Human LTA-31534TH Recombinant Human LTA, His-tagged His
    Human LTA-31535TH Recombinant Human LTA E.coli N/A
    Human LTA-31536TH Recombinant Human LTA, His-tagged His
    Human LTA-4597H Recombinant Human LTA Protein, GST-tagged Wheat Germ GST
    Human LTA-4599H Recombinant Human LTA Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
    Human LTA-5067H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1) Human N/A
    Human LTA-5068H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged Human His
    Human LTA-554H Recombinant Human LTA, None tagged E.coli N/A
    Human LTA-568H Recombinant Human LTA protein, His & T7-tagged E.coli His/T7
    Human LTA-9167HCL Recombinant Human LTA 293 Cell Lysate HEK293 N/A
    Human TNFB-89H Human Tumour Necrosis Factor beta (rDNA derived) Reference standard N/A
    Mouse Lta-1346M Recombinant Mouse Lta Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Lta-569M Recombinant Mouse Lta protein, His-tagged E.coli His
    Mouse Lta-90M Mouse Tumour Necrosis Factor alpha (rDNA derived) Reference standard N/A
    Mouse LTA-9342M Recombinant Mouse LTA Protein Mammalian Cell His
    Rat LTA-3497R Recombinant Rat LTA Protein Mammalian Cell His
    Rat Lta-571R Recombinant Rat Lta protein, His-tagged E.coli His
    Rhesus Macaque LTA-2589R Recombinant Rhesus monkey LTA Protein, His-tagged Mammalian Cell His
    Dog LTA-567D Recombinant Dog LTA protein, His-tagged E.coli His
    Rabbit LTA-572R Recombinant Rabbit LTA protein, His & T7-tagged E.coli His/T7
    Zebrafish LTA-3065Z Recombinant Zebrafish LTA Mammalian Cell His
    Pig LTA-570P Recombinant Pig LTA protein, His & T7-tagged E.coli His/T7

    lta involved in several pathways and played different roles in them. We selected most pathways lta participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with lta were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL25; GDF5; TNFRSF1B; CSF1; CTF1; CXCL8; GHRA; GH1; IL23R; LEPB
    NF-kappa B signaling pathway GM1987; PIDD1; TICAM2; TRAF6; Ccl21a; BIRC3; IL-8; TNFRSF1A; ICAM1; GADD45B
    TNF signaling pathway CASP8; RIPK1; FAS; CREB3L3; Ccl12; MMP14; CCL20; RPS6KA5; IKBKB; CXCL3
    Type I diabetes mellitus INS1; TNF; HLA-F; HLA-DRB3; HLA-DMB; CPE; HLA-E; GAD1; FASLG; GZMB
    HTLV-I infection NFYB; SLC25A4; TGFB2; EGR1; CD3D; HLA-DRB3; CCND2; TGFBR2; LCK; PIK3R1
    Herpes simplex infection TAF4B; MHC1UEA; SRSF6; IKBKG; ABCB3L1; SKP1; MHC2DAB; BLA; IFNAR1; HMGN1

    lta has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by lta itself. We selected most functions lta had, and list some proteins which have the same functions with lta. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CCL38.1; WNT1; PRL7D1; ADIPOQ; IL33; Fasl; IFN-a; Gm13290; IL28A; GDF10
    receptor binding GLA; CADM3; CYTL1; PDGFRB; HLA-A; NPFF; ACOT8; PTK2; WNT7AA; GIPC1
    tumor necrosis factor receptor binding TRAF3; TRAF4; TNFSF11; TRAF2; BRE; CASP8; TRAP1; TNFSF10L3; LTA; TNFSF10L4

    lta has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lta here. Most of them are supplied by our site. Hope this information will be useful for your research of lta.


    Leroux-Kozal, V; Leveque, N; et al. Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load. HUMAN PATHOLOGY 46:443-453(2015).
    Dammermann, W; Bochmann, D; et al. CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists. JOURNAL OF IMMUNOLOGICAL METHODS 414:82-90(2014).

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