Recombinant Human Activin A Receptor, Type I, GST-tagged, Active ACVR1-239H

Recombinant Human Activin A Receptor, Type I, GST-tagged, Active

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Recombinant Human Activin A Receptor, Type I, GST-tagged, Active

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Cat. No. : ACVR1-239H
Product Overview : Recombinant human ALK2 (147-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag.MW = 67 KDa.
Description : ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFβRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.
Source : Sf9 insect cells using baculovirus.
Sequence : 147-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : VR1 activin A receptor, type I [ Homo sapiens ]
Synonyms : ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
MIM : 102576
UniProt ID : Q04771
Chromosome Location : 2q23-q24
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding

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