"ACVRL1" Related Products

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Recombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active

Cat. No.: ACVRL1-238H
Product Overview: Recombinant human ALK1 (144-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=64 kDa.
Description: ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFβ superfamily. ALK1 functions as a TGFβ type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFβ signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported.
Source: Sf9 insect cells using baculovirus.
Sequence: 144-end.
Applications: Kinase Assay, Western Blot.
Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ]
Synonyms: ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; serine/threonine-protein kinase receptor R3; EC 2.7.11.30
Gene ID: 94
mRNA Refseq: NM_000020
Protein Refseq: NP_000011
MIM: 601284
UniProt ID: P37023
Chromosome Location: 12q11-q14
Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function: ATP binding; SMAD binding; activin receptor activity, type I; magnesium ion binding; nucleotide binding; receptor activity; transferase activity; transforming growth factor beta binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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