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Recombinant Human ANGPT1

Cat.No. : ANGPT1-27316TH
Product Overview : Recombinant fragment of Human Angiopoietin 1 with a N terminal methionine; 480 amino acid with a predicted of MWt 55.6 kDa.
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  • Gene Information
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Description : Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Protein length : 480 amino acids
Molecular Weight : 55.600kDa
Source : E. coli
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 6.01% Urea, 5% Glycerol
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MSNQRRSPENSGRRYNRIQHGQCAY TFILPEHDGNCRESTTDQYNTNALQ RDAPHVEPDFSSQKLQHLEHVMENY TQWLQKLENYIVENMKSEMAQIQQN AVQNHTATMLEIGTSLLSQTAEQTR KLTDVETQVLNQTSRLEIQLLENSL STYKLEKQLLQQTNEILKIHEKNSL LEHKILEMEGKHKEELDTLKEEKEN LQGLVTRQTYIIQELEKQLNRATTN NSVLQKQQLELMDTVHNLVNLCTKE GVLLKGGKREEEKPFRDCADVYQAG FNKSGIYTIYINNMPEPKKVFCNMD VNGGGWTVIQHREDGSLDFQRGWKE YKMGFGNPSGEYWLGNEFIFAITSQ RQYMLRIELMDWEGNRAYSQYDRFH IGNEKQNYRLYLKGHTGTAGKQSSL ILHGADFSTKDADNDNCMCKCALML TGGWWFDACGPSNLNGMFYTAGQNH GKLNGIKWHYFKGPSYSLRSTTMMI RPLDF
Sequence Similarities : Contains 1 fibrinogen C-terminal domain.
Gene Name : ANGPT1 angiopoietin 1 [ Homo sapiens ]
Official Symbol : ANGPT1
Synonyms : ANGPT1; angiopoietin 1; angiopoietin-1; Ang1; KIAA0003;
Gene ID : 284
mRNA Refseq : NM_001146
Protein Refseq : NP_001137
MIM : 601667
Uniprot ID : Q15389
Chromosome Location : 8q23.1
Pathway : Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function : receptor tyrosine kinase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Is there any research on the role of ANGPT1 in neurological disorders? 12/04/2022

While ANGPT1 is primarily associated with blood vessel formation and stability, recent studies have indicated potential involvement of ANGPT1 in neurological disorders. For example, it has been suggested that ANGPT1 may play a role in Alzheimer's disease, stroke, and neuroinflammation. However, further research is required to understand the precise role of ANGPT1 in these neurological conditions.

Are there any known interactions or regulators of ANGPT1? 09/14/2022

The activity of ANGPT1 is tightly regulated by different factors. Vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) are known to collaborate with ANGPT1 to regulate blood vessel formation and stability. Several transcription factors, signaling molecules, and microRNAs have also been identified as regulators of ANGPT1 expression.

Does ANGPT1 play a role in vascular development during embryogenesis? 12/29/2021

Yes, ANGPT1 is involved in vascular development during embryogenesis. It promotes blood vessel maturation and stabilization, which is essential for the formation of a functional vascular system. ANGPT1, along with its receptor Tie2, regulates the interactions between endothelial cells and pericytes, leading to the formation of stable blood vessels. Deficiency in ANGPT1 or Tie2 during embryonic development can result in abnormal blood vessel formation and defects in vascular morphogenesis.

Can ANGPT1 be used as a therapeutic target for cancer? 08/05/2021

ANGPT1 has been implicated in tumor angiogenesis, which is the process of formation of new blood vessels to supply oxygen and nutrients to tumors. Its expression is often elevated in certain types of cancer, and it promotes tumor growth and metastasis. Therefore, ANGPT1 has been considered as a potential therapeutic target for cancer. Several approaches, such as blocking ANGPT1/Tie2 signaling using antibodies or small molecules, have shown promising results in preclinical studies. However, further research is needed to determine the efficacy and safety of ANGPT1-based therapies in clinical settings.

Are there any known inhibitors or activators of ANGPT1? 07/13/2021

Several factors have been identified that can either inhibit or activate ANGPT1 signaling. For example, VEGF, another pro-angiogenic factor, can promote ANGPT1 expression and enhance its activity. On the other hand, certain molecules, such as angiostatin and endostatin, have been shown to block ANGPT1-induced angiogenesis. Furthermore, there are ongoing studies to develop therapeutics that directly target ANGPT1 or its receptor Tie2 to modulate its activity.

Is ANGPT1 involved in wound healing? 03/04/2021

Yes, ANGPT1 is involved in the process of wound healing. It promotes angiogenesis in the injured area, which helps to supply oxygen and nutrients to the healing tissues. ANGPT1 also plays a role in tissue remodeling and repair by promoting the migration of certain cells, such as fibroblasts, which contribute to wound closure. Additionally, it may help to reduce inflammation and support the formation of new blood vessels during the healing process.

Are there any ongoing clinical trials investigating ANGPT1 in the context of cancer or other diseases? 01/14/2021

While there are currently no registered clinical trials specifically investigating ANGPT1 as a therapeutic target, there are ongoing studies exploring the efficacy of agents that block or modulate ANGPT1 signaling in various diseases, including cancer. These studies aim to evaluate the safety and effectiveness of ANGPT1-targeted therapies in preclinical and clinical settings and may provide valuable insights into the potential clinical applications of ANGPT1 inhibition or stimulation.

Is ANGPT1 involved in wound healing? 11/12/2020

Yes, ANGPT1 has been implicated in wound healing and tissue repair processes. It promotes angiogenesis and stabilizes newly formed blood vessels, which are crucial for delivering oxygen and nutrients to healing tissues. ANGPT1 also stimulates the recruitment and maturation of pericytes, which aid in wound healing by providing structural support to blood vessels.

Is ANGPT1 associated with lymphangiogenesis? 06/13/2020

While ANGPT1's primary role is in angiogenesis, the formation of blood vessels, it has also been reported to play a role in lymphangiogenesis, the formation of lymphatic vessels. ANGPT1-Tie2 signaling has been shown to regulate lymphatic vessel growth and maturation. However, the precise mechanisms and significance of ANGPT1 in lymphangiogenesis are still under investigation.

Are there any genetic disorders associated with ANGPT1? 05/16/2020

Currently, no inherited disorders directly linked to ANGPT1 gene mutations have been reported. However, dysregulation of ANGPT1 expression and abnormal Tie2 signaling have been implicated in various diseases, including retinopathy, inflammatory conditions, and cancer.

Are there any clinical trials underway investigating ANGPT1-based therapies? 05/15/2020

At present, there are no clinical trials specifically focused on ANGPT1-based therapies. However, there are clinical trials investigating the use of ANGPT1 in combination with other molecules, such as VEGF inhibitors or immune checkpoint inhibitors, for various cancers. These trials aim to assess the efficacy and safety of ANGPT1-targeted therapies as part of a comprehensive treatment strategy.

Are there any genetic mutations or polymorphisms in the ANGPT1 gene associated with diseases? 04/16/2019

While genetic mutations or polymorphisms in the ANGPT1 gene have not been extensively studied, some studies have reported associations with certain diseases. For example, specific variations in the ANGPT1 gene have been linked to susceptibility to age-related macular degeneration (AMD) and diabetic retinopathy. However, more research is needed to establish the significance of these genetic variants and their impact on disease development.

Can ANGPT1 be used as a diagnostic marker for any diseases? 11/18/2018

ANGPT1 is not commonly used as a diagnostic marker for specific diseases. However, its levels have been found to be altered in certain conditions, such as cardiovascular diseases, diabetic retinopathy, and sepsis, which suggests its potential as a biomarker. Further research is needed to establish ANGPT1 as a reliable diagnostic marker.

How is ANGPT1 regulated at the transcriptional level? 10/03/2018

The transcriptional regulation of ANGPT1 is complex and involves various factors. Several transcription factors, such as hypoxia-inducible factors (HIF-1α), Sp1, and NF-κB, have been shown to directly bind to the ANGPT1 gene promoter and regulate its expression. In addition, signaling pathways like VEGF and TGF-beta can influence ANGPT1 expression by activating downstream transcription factors that interact with the ANGPT1 promoter region. MicroRNAs also play a role in post-transcriptional regulation of ANGPT1 expression.

What are the potential therapeutic applications of ANGPT1? 03/18/2018

ANGPT1 has shown potential therapeutic value in various medical conditions. It is being explored for its ability to promote blood vessel formation and stabilize existing blood vessels in disorders such as cardiovascular diseases, diabetic retinopathy, and tumor angiogenesis. Additionally, ANGPT1 has been investigated for its potential in tissue engineering and regenerative medicine approaches.

What are the potential side effects or concerns associated with targeting ANGPT1 for therapy? 05/21/2017

One potential concern with targeting ANGPT1 for therapy is the potential for adverse effects on normal physiological processes. ANGPT1 plays a crucial role in vascular development and stability, and its blockade or manipulation could have unforeseen consequences on blood vessel formation and function. Additionally, since ANGPT1 is involved in various biological processes, there might be off-target effects that could lead to unintended consequences. Therefore, careful evaluation of ANGPT1-targeted therapies is necessary to ensure safety and minimize potential side effects.

Is ANGPT1 involved in cancer progression or metastasis? 11/04/2016

ANGPT1 can have both tumor-suppressive and tumor-promoting effects depending on the context. In some cancers, ANGPT1/Tie2 signaling can inhibit tumor angiogenesis and limit metastasis. Conversely, in certain types of tumors, ANGPT1 can induce angiogenesis, promoting tumor growth and metastasis. Further research is necessary to understand the complexities of ANGPT1's role in different types and stages of cancer.

Are there any inhibitors or activators of ANGPT1 that have been identified? 09/18/2016

Several molecules have been identified as modulators of ANGPT1/Tie2 signaling. For example, antibodies that activate or block Tie2 receptor have been developed for experimental purposes. In addition, small-molecule inhibitors targeting the ANGPT1/Tie2 pathway are being investigated as potential therapeutic agents for diseases involving abnormal angiogenesis.

Customer Reviews (5)

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Reviews
02/19/2022

    ANGPT1 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

    09/10/2020

      It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.

      08/24/2020

        It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.

        08/21/2019

          ANGPT1 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

          10/14/2018

            ANGPT1 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

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